mat francois

Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong oncogenic infection in lymphatic endothelial cells (LECs) by ensuring episomal maintenance of its genome via the viral protein LANA. Efficient ...

"Wonderful collaboration with the Ojala lab that brings together developmental biology and virology to uncover a molecular strategy used by a herpes virus to ensure its genome's persistence in lymphatic endothelial cells."👇

www.biorxiv.org/content/10.1...

Inhibiting SOX18 with propranolol restores vascular integrity in NR2F2-driven malformations Genomics has advanced our ability to identify disease-causing mutations, but translating this information into treatments remains challenging, particularly for rare genetic diseases. Key challenges re...

Wonderful collaboration with the Red-Horse lab and the NSW Hunter Hospital to combine human genetics, stem cell biology and single molecule science to identify the cause of a rare vascular disease and enable its pharmacological management. 👇 www.biorxiv.org/content/10.1...