Ruth Amy Purcell

And of course, none of this would have been possible without the input from a hugely collaborative, interstate clinical team and the support of many scientists and clinicians @thedohertyinst.bsky.social

We find that an array of inflammatory biomarkers (including cytokines, agalactosylated IgG, and atypical B cells) are elevated in solid tumor patients. These biomarkers negatively correlate with neutralizing antibody responses, but not with antibodies against conserved epitopes or with Fc functions.

In contrast, two COVID-19 mRNA vaccine doses induced robust Fc effector functions, such as antibody-dependent phagocytosis and cytotoxicity, in solid tumor malignancy patients.

SARS-CoV-2 neutralizing antibody responses were significantly lower and less cross-reactive in two-dose mRNA vaccinated solid tumor patients as compared to age-matched controls.
A third mRNA vaccination was required to boost neutralizing responses to comparable levels in patients and controls.

Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination - npj Vaccines npj Vaccines - Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination

Our paper exploring the effects of solid tumor malignancy-associated inflammation upon COVID-19 vaccine-induced antibodies is finally live!
We show that while dysregulated inflammation impairs neutralization, variant cross-reactive Fc effector functions remain robust.

www.nature.com/articles/s41...

Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠

Macrophages direct location-dependent recall of B cell memory to vaccination Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation.

@smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social

Fantastic to have our study out describing the nuances of increased SARS-CoV-2 IgG4 following repeated mRNA vaccination 💉💉💉 @amywchung.bsky.social @kev-in-science.bsky.social @viralvaxlab.bsky.social
And great discussion started below!