bioRxiv Biochemistry

An Automated HDX-MS Platform for in situ characterisation of Membrane Proteins https://www.biorxiv.org/content/10.64898/2026.03.06.710074v1

Fast and Luminous: CLIP-tag2 https://www.biorxiv.org/content/10.64898/2026.03.05.709795v1

Structural insights into the inactive state of the adhesion GPCR ADGRV1 https://www.biorxiv.org/content/10.64898/2026.03.05.709805v1

Nar1 binds the cytosolic iron sulfur cluster assembly targeting complex via a bipartite interaction interface https://www.biorxiv.org/content/10.64898/2026.03.06.710161v1

Phosphorylation of the C-terminus of PI4KA inhibits lipid kinase activity https://www.biorxiv.org/content/10.64898/2026.03.06.710086v1

Suppression of ITPK1 and IPMK activities impairs mTORC1 signaling in pancreatic β-cells and implicates IP5 in stabilizing activated mTORC1 https://www.biorxiv.org/content/10.64898/2026.03.04.709646v1

Integrated proteomic and phosphoproteomic profiling reveals mechanisms of Bisphenol-A induced placental toxicity https://www.biorxiv.org/content/10.64898/2026.03.04.709712v1

A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric Proteins https://www.biorxiv.org/content/10.64898/2026.03.06.710105v1

An Optimized RNF126-Targeting Covalent Handle for Molecular Glue Degraders https://www.biorxiv.org/content/10.64898/2026.03.06.709959v1

DNA Adenine Methylation Clock in Brain Aging and Alzheimer's Disease Progression https://www.biorxiv.org/content/10.64898/2026.03.05.709867v1

Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs https://www.biorxiv.org/content/10.64898/2026.03.05.709631v1

Systematic assessment of the impact of targeted selection methods and environment-mimicking culture conditions on fungal natural product libraries https://www.biorxiv.org/content/10.64898/2026.03.04.709592v1

UbiB proteins mediate an ATP-dependent decarboxylation step in bacterial ubiquinone biosynthesis https://www.biorxiv.org/content/10.64898/2026.03.05.709815v1

Non-coding RNA RsaE regulates biofilm thickness, viability and dissemination in methicillin-resistant Staphylococcus aureus https://www.biorxiv.org/content/10.64898/2026.03.05.709773v1

Comparison of extracellular vesicles and mechanically induced vesicles for structure determination of membrane proteins https://www.biorxiv.org/content/10.64898/2026.03.04.709473v1

Identification and functional characterization of CXCL17 in cartilaginous fishes reveals an ancient origin of the CXCL17-GPR25 signaling pathway https://www.biorxiv.org/content/10.64898/2026.03.04.709523v1

''Self-gapping'' by a C-terminal domain arginine finger regulates GTP hydrolysis in bacterial zinc metallochaperones https://www.biorxiv.org/content/10.64898/2026.03.03.709369v1

An omega glutathione S-transferase in Apis mellifera contributes to chemical adaptation through pesticide sequestration and antioxidant defense https://www.biorxiv.org/content/10.64898/2026.03.03.709375v1

Functional Locality-Aligned Learning Reveals Structure-Function Causality in Enzyme Kinetics https://www.biorxiv.org/content/10.64898/2026.03.04.709726v1

Miniprotein inhibitors of the Staphylococcus aureus efflux transporter NorA https://www.biorxiv.org/content/10.64898/2026.03.05.709893v1

MauE from Calditrichota and Thermodesulfobacteriota reveal a new pathway for disulfide bond formation in bacteria https://www.biorxiv.org/content/10.64898/2026.03.05.709764v1

Unspecific Molecular Adsorption (UMA) sample preparation method for bottom-up and whole protein analysis. The foundation. https://www.biorxiv.org/content/10.64898/2026.03.02.709073v1

Conformational signatures of native ligand and pharmacochaperone binding in rhodopsin https://www.biorxiv.org/content/10.64898/2026.03.03.709294v1

Development of Carboxymethyl Cellulose (CMC)-Based Bio-composites as a Functional Substitute for Single-Use Plastics for Active Food Packaging Applications https://www.biorxiv.org/content/10.64898/2026.02.22.707343v1

Impact of Sequential Processing (Boiling and Fermentation) on the Nutritional, Anti-nutrient, and Antioxidant Profile of Manihot esculenta Tubers. https://www.biorxiv.org/content/10.64898/2026.03.03.709334v1

Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella https://www.biorxiv.org/content/10.64898/2026.03.03.709364v1

Traceless protein semi-synthesis in cells using the promiscuous ultra-fast split intein NrdJ-1 https://www.biorxiv.org/content/10.64898/2026.03.03.709324v1

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine https://www.biorxiv.org/content/10.64898/2026.03.03.709336v1

Mutagenesis study of a Bacteriophytochrome - insights for the development of labels for optical imaging. https://www.biorxiv.org/content/10.64898/2026.03.03.708993v1

Hierarchical Anchoring Gating Dictates Specific H4K16 Acetylation by the Human MSL Complex https://www.biorxiv.org/content/10.64898/2026.03.03.709310v1