Ryann Tansey

I will be presenting much of the cannabinoid work I have been doing in the Mental Health and Addiction Program Rounds. My talk "Pharmacological Manipulation of the Endocannabinoid System" ties together my work with @mayoonthebrain.bsky.social and my current work with @brainsbeesbikes.bsky.social

The Manning Lab - we are small yet mighty!

From left to right Sarah Rodriguez-Valtierra, me, Alena Ionova, and Grace Burns

Thank you to my co-authors @neuroip.bsky.social @connorhaggarty.bsky.social @raeganmazurka.bsky.social @madeleinejones.bsky.social @cannabrain.bsky.social @mayoonthebrain.bsky.social and all the others who do not have bluesky.

And of course the greatest thanks to the patients who participated!

I'm so happy this is finally out! My first empirical paper from my postdoc, and my first time wading into fMRI in a clinical sample.

See inside: FAAH inhibition may not have done anything beyond exposure CBT in PTSD, but the DLPFC may play more of a role in treatment response than we thought...? 🤔

Proud father to a beautiful, 14 paper special issue 🥲

HAPPENING RIGHT NOW!
Get in, support your fellow postdocs!

Happy new year OHBMers! ✨Are you (or someone you know) a superstar when it comes to incorporating sustainability into research?

Make sure to submit a nomination for the OHBM 2026 Sustainability Award! 🍃🌱🌍🏆

Due Feb 3 @ 11:59 PM EST! More info here: www.humanbrainmapping.org/i4a/pages/in...

Congrats to @abby-lunge.bsky.social on her first first author paper!! 🎉🎉

A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis A network of basolateral amygdala neurons, but not singular projections, contributes to the neuroendocrine response to stress.

New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses.

www.science.org/doi/10.1126/...

So excited to be a part of this stellar group of travel awardees this year!! See you at #ACNP2026 🏝️☀️🔬

Happy New Preprint Friday!* Thrilled to share new results in collab with Sarah Lichenstein & @yiplab.bsky.social showing our brain's functional connections reflect the environments we grow up in!
tinyurl.com/exposomeConnectivity

#neuroskyence #PsychSciSky #DevPsy #cognition
*can this be a thing??

Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals - Molecular Psychiatry Molecular Psychiatry - Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals

Excited to share recent collaborative work led by Hayley Thorpe published in Molecular Psychiatry: Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals www.nature.com/articles/s41...

The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults - Psychopharmacology Rationale Stimulant drugs such as methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA) can impact neurobiological systems implicated in stress, reward processing, and drug use. Although recent preclinical evidence implicates the endocannabinoid (eCB) system in these processes, little is known about the acute effects of stimulants on eCB levels in humans. Objectives The aim of the present study was to investigate the effects of acute administration of the prototypical psychostimulant MA and the psychostimulant-empathogen MDMA on circulating eCB levels in healthy adults. Methods Using a within-subject, double-blind design, this study assessed the acute effects of MA (20 mg), MDMA (100 mg), and placebo on plasma eCB levels in healthy human participants (N = 22) during three separate sessions. Blood samples assessing concentrations of the eCBs anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) were collected between 150- and 180-minutes post-drug administration, and subjective measures of drug effects were collected at regular intervals. Results MA, but not MDMA, was associated with significantly lower 2-AG plasma concentrations compared to placebo. Neither drug impacted AEA concentrations. However, during the placebo condition, higher AEA concentrations were correlated with disliking the ‘drug effects’, suggesting a possible relationship between AEA levels and negative expectations of subjective drug effects. Conclusions These findings provide novel insights into how stimulant drugs act on the eCB system and may help to develop treatments for SUDs.

Congrats to @pact-lab.bsky.social PhD student @anadeutsch.bsky.social on her 1st first-author paper from the lab! 🎉

She explored how MDMA & methamphetamine impact cortisol, endocannabinoids, & BDNF levels in healthy humans and how this relates to the subjective drug experience 💊👇

OHBM Sustainability & Environmental Action Special Interest Group (SEA-SIG) | LinkedIn OHBM Sustainability & Environmental Action Special Interest Group (SEA-SIG) | A group within the Organization of Human Brain Mapping (OHBM) working to reduce the environmental impact of neuroimagi...

The SEA-SIG is now on LinkedIn!! 💼

Come connect with us over there as well!

www.linkedin.com/company/ohbm...

@ohbmofficial.bsky.social @ohbmtrainees.bsky.social @ohbm-dic.bsky.social @ohbm-com.com @ohbmbrainart.bsky.social @ohbmossig.bsky.social @ohbm-australia.bsky.social

‼️ If you're interested in getting involved with the SEA-SIG, we are accepting nominations for the roles of Chair, Secretary, and Treasurer until OCTOBER 5! ‼️

✨ 💫 🌍 🌱 🍃

@anadeutsch.bsky.social lead her first symposium on stress and psychedelics at #ebps2025 including her own talk alongside Dr. Gibson Cook and Dr. Helena Aicher. Go Ana 🥳

Everyone!! Make sure you attend our first seminar back for the fall tomorrow - it's going to be great!!

Happening on Thursday week!

Register here: us06web.zoom.us/webinar/regi...

Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h

The carbon footprint of conferences is large – but fully virtual meetings can reduce the environmental impact by 99%! You can keep sustainability in mind while learning & connecting with researchers around the globe by attending the OHBM Satellite Meeting September 10-12!

A Garden in September
Mary Hiester Reid
c. 1894

🗓️ Only ONE WEEK to register for the OHBM Virtual Satellite Meeting, hosted with the SEA-SIG @ohbmenvironment.bsky.social! There will be an educational course, 3 symposia, and a can’t-miss keynote from Dr. Michael Breakspear! You won’t want to miss it!

Thanks to @drjkhokhar.bsky.social & Cece Hillard for another fantastic Cannabinoid GRC!

The #cannabinerd crew is unparalleled & I couldn't be more excited for the opportunity to organize the 2029 meeting with @ryanmcpickle.bsky.social

And just like that #CannabinoidGRC2025 comes to an end! Big thank you to all the attendees and speakers and congrats to @mayoonthebrain.bsky.social and @ryanmcpickle.bsky.social on their selection as chairs for the 2029 meeting!

The cannabinoid half of the @pact-lab.bsky.social enjoying a night out in Boston before heading for a week of science at the Cannabinoid GRS & GRC 🧪 😎

@marcdferger.bsky.social
@abby-lunge.bsky.social

a man says you really are a dream team in front of a microphone ALT: a man says you really are a dream team in front of a microphone

Wishing all the #Cannabinerd trainees a Happy Cannabinoid GRS kickoff!

Grateful to see @pact-lab.bsky.social well represented w/ talks from @ryanntansey.bsky.social & @abby-lunge.bsky.social, @marcdferger.bsky.social as a discussion leader, & Gavin Petrie as co-Chair (& later speaker at the GRC) 💪

So honored to collaborate with this powerhouse group led by @mayoonthebrain.bsky.social 🌟

Grateful to @ryanntansey.bsky.social, @marcdferger.bsky.social, @pact-lab.bsky.social for the opportunity to contribute to this important work on the endocannabinoid system & developmental psychopathology! 🙌🧠

Obviously huge thanks to @hmarusak.bsky.social for her invaluable contributions & feedback, and to @mayoonthebrain.bsky.social for supervising it all!

Realizing now that I never advertised my FIRST first author publication of my postdoc here... shared first authorship with @marcdferger.bsky.social of course! 💫

Very proud of this review that perfectly branches between the developmental work I did in my PhD & what I've been doing in the PaCT Lab! 🧠

Don't miss @drbreaky.bsky.social's keynote at our OHBM VIRTUAL SATELLITE MEETING!! 🌍 🛰️ 🍃

Make sure you register before September 4!!

The keynote speaker for the OHBM Virtual Satellite Meeting is Dr. Michael Breakspear, @drbreaky.bsky.social! You won’t want to miss his talk – your only chance will be to register and catch it live at 12:00-13:00 UTC on September 11!

🔗 https://humanbrainmapping.org/25SEASIG

#OHBM #SEASIG