FlexNP

The drugs are part of the toolbox. Yes avoid high calorie foods. Yes move your body. But also for a lot of my patients the drugs *allow* them to do those things.

The biggest issue is we've created an entire world with less physical labor, more convenient *everything* more high calorie *everything* you can live a comfortable sedentary life because that's the world society built.

Not an excuse but reality.

And I'll add you get to navigate some really weird contradictory information while still trying to be understanding.

One patient took every vaccine we offer but HPV. Calling that one the "vaccine for wh*res"

And you just have to maintain the poker face professionalism

The one of the next frontiers for GLP1 meds is neuroscience/addiction disorders. This recently published study looking at various substance use disorders and older GLP1 medications shows a modest benefit across the board

www.bmj.com/content/392/...

Oof why the hell....79-80 is where I have the "what meds do you not wanna take anymore" talk because that's the point of rapidly diminished returns!

Oof. Yeah that's an issue. Overnight to charge the plug in is usually a $1-1.25 per 45 miles with our overnight rates so that math works well in our favor.

My bigger issue is all the public charging stations are stupid expensive

As I said earlier, glad to have a plug in hybrid that gets ~45 miles to a charge and only needs gas about once a month with our driving habits

Boy am I glad our one car is a plug-in hybrid and basically needs gas about once a month or less, especially in warmer weather months.

This is such a truth bomb. Even tho I do PCP work the amount of patients who stop meds because they ballooned 40 pounds on an atypical antipsychotic is innumerable.

A dual GIP/GLP1 would directly counteract those effects. And if it happens to have a benefit of mood stabilization that would be incredible. These drugs continue to do amazing things and I can't wait to see what the next couple years brings.

It's called Brenipatide and it now has 8 trials running mostly for SUD but also for adjunctive therapy for depression, bipolar and schizophrenia. Psych meds, especially for BPD and schizo are well known to increase lipids, cause weight gain and insulin resistance.

It even shows, importantly a decrease in mortality (tho the CI is broad) regardless about a 20% reduction in SUD is nothing to sneeze at when you consider our current treatments. I believe this also explains why Eli Lilly has went hard into SUD and mental health with a new GLP1/GIP dual agonist

The one of the next frontiers for GLP1 meds is neuroscience/addiction disorders. This recently published study looking at various substance use disorders and older GLP1 medications shows a modest benefit across the board

www.bmj.com/content/392/...

Yup. Definitely have those days on occasion even after 2.5 years I still have days where I'll get post shot fatigue or some extra intense appetite suppression or satiety. But 95% of the time it's just nice to not think about food all the time and feel so much healthier.

Hope the same for you

!!!!!!! 👀👀

Trial finished on February 20th...so we should have initial topline phase 3 data for retatrutide and diabetic patients over a 40 week period in late March!!!! Ahhhhhhh!!!!

BIC tolerability confirmed. But the weight loss is....consistent?

Yes ma'am!

The Kwikpen you can dial a dose by counting clicks 😉

CEO be dumb! I mean probably best in class tolerability it sounds like. But the weight loss is 🙈

I'm all for more weight loss options, especially tolerable ones but this one ain't great!

Once again I suspect calcitonin is holding it back.

Also I wouldn't be so harsh if the CEO hadn't said this would be best in class results. Ahhh nope. Not even close.

Another DACRA. Another subpar weight loss result. Just say no to DACRA for weight loss. Petrelintide is a Amylin 3R-Calcitonin agonist. Tolerability was great. Similar to placebo.

Weight loss was only 9% and only for the highest dose. No report on other doses.

!!!!!!! 👀👀

Trial finished on February 20th...so we should have initial topline phase 3 data for retatrutide and diabetic patients over a 40 week period in late March!!!! Ahhhhhhh!!!!

That is a true galaxy brain take. Make the highly flammable tankers pass through an even MORE NARROW choke point.

*After you literally blast a path through mountains that are >4000 feet high

Their other expenses go down. Less on groceries especially. They can easily recoup that cost from cost savings on food. Also many can stop other meds like BP meds as their weight comes down.

Ultimately this is a massive win for long term access. Let the price wars continue!

For example an employer could add this as a rider that patients buy to defray the cost. Employer might pay $300 of that 449, leaving the patient to pay 149/month for Zepbound. Expensive yes BUT a lot of my patients are willing to pay that amount monthly because....

especially because the PBMs have not been passing through 100% of the rebates, they pocket most of that money for themselves!

Employers would then determine how much they would shoulder and how much to pass on to their employees if they want to add Zepbound to their list of covered drugs

What does that mean in English?

The $449 cost (plus whatever fees come from the program administrator some of which have lower overheads than others IS LIKELY lower than the net prices plans/employers are receiving via insurance/PBMs after "rebates" aka kickbacks to the PBM from Lilly

Huge announcement by Eli Lilly this morning that undercuts PBMs and their competitor Novo

"Zepbound® (tirzepatide) KwikPen® for single-patient use available from Lilly at $449 across all doses through the Lilly Employer Connect platform, with reduced cost-share pricing available to employees"

Gotta say the 2 trials Lilly is running with tirzepatide for T1D have me very excited for you and millions of other T1D patients. Better glycemic control, less insulin, better renal outcomes. Would be a huge boon for T1D if approved in a couple years

The irony is RFK absolutely has to be using melanotan to have that level of tan skin.