Hetty Carraway

This evening!

Evolution of MDS Management Hinges on Standardized Disease Classification, Molecularly Informed Risk Stratification Hetty E. Carraway, MD, MBA, highlights the evolving molecular classification of MDS and novel agents in the therapeutic arsenal.

Evolution of MDS Management Hinges on Standardized Disease Classification, Molecularly Informed Risk Stratification
@carrawayhetty.bsky.social @clevelandclinic.bsky.social #MDS #mdssm
www.onclive.com/view/evoluti...

What a fantastic night for dreams coming true! Can't wait to watch all of their journeys continue!

Amid NIH Cuts, ASH Expands Eligibility for Midcareer Research Awards The American Society of Hematology (ASH) was already looking to expand its Bridge Grant program when changes to the National Institutes of Health (NIH) funding landscape created greater urgency.

More researchers are now eligible for the ASH Bridge Grant!

With NIH funding cuts disrupting study sections, ASH expanded eligibility for midcareer investigators.

Learn how ASH is taking action to support hematology researchers: https://bit.ly/4hW5arC

#ASHAwards #Fight4Hematology #HemeSky

Cutting HHS staff to “save money” is like firing all the firefighters to lower the city’s water bill - it makes no damn sense

Staff are less than 1% of the HHS budget - but they’re the ones who respond when there’s a fire

They’re not saving money. They’re letting it (our health) all burn

🚒💨 🔥🏥🔥

Paige Bueckers has set a new UConn WBB record for points in an NCAA Tournament game in today's win over Oklahoma 🔥

◽ 40 PTS
◽ 16/27 FG
◽ 6/8 3-PT FG

A review on the role of #MDM2 in regulating the #ImmuneMicroenvironment, tumor #ImmuneEvasion, & hyperprogression during #immunotherapy, with insights on the application of MDM2 inhibitors in combination with immunotherapy in tumors with MDM2 overexpression. #medsky

www.sciencedirect.co...

🙌❤️🍾

My first @bloodjournal.bsky.social article!

T cell malignancies after CAR T cell therapy in the DESCAR-T registry - Nature Medicine This analysis of the registry database DESCAR-T of more than 3,000 pediatric and adult patients with hematological malignancies who received CAR T cell therapy in France between 2018 and 2024 shows th...

Happy to share our work published in Nature Medicine!

We analyzed 3,066 patients from the French DESCAR-T registry who received #CARTcell therapy. Our findings indicate a very low risk of T-cell malignancy after CAR T-cell therapy: only 1 case (0.03%). www.nature.com/articles/s41...

How I Do It: Interpreting Clinical Trial Results

An excellent rubric for understanding and interpreting randomized clinical trials in #journal_CHESTCritCare: hubs.la/Q030pjgL0
#JournalCHEST

10 Questions With Kaitlyn Dykes, chair of #ASHTrainee Council

📰In this ASH News Daily article, Dr. Dykes is asked "Who's your ASH-lebrity/the ASH luminary you most admire?"

Read more for the answer. And tell us: who's your ASH-lebrity? https://bit.ly/3ZIzD5G #ASH24

#HemeSky #Hematology

Karen Knudsen: Cancer prevention is one of the most critical challenges of our time - OncoDaily Karen Knudsen: Cancer prevention is one of the most critical challenges of our time / Abu Dhabi, Altagracia Gomez, Arthur C. Brooks, Bojan Obradović, cancer,

Cancer prevention is one of the most critical challenges of our time - Karen Knudsen
@drkarenknudsen.bsky.social

oncodaily.com/blog/215298

#Medicine #Health #Oncology #OncoDaily #Cancer

My New Year’s resolution is to berate myself less for things I wish I could have done better, to learn from my mistakes, and give myself more credit for the things I did well but promptly forgot/ignored because academics love to live from crisis to crisis

Happy new year!

Our assessment of a person's epigenetic ("biological") age has been centered on DNA methylation. A new report shows that a set of 7 histone markers has comparable accuracy and also uncovers new pathways of aging biology
www.science.org/doi/10.1126/...

Aging clock based on nucleosome reorganisation derived from cell‐free DNA We show that aging is associated with an increase in the distance between nucleosomes, which can be used to predict a person's age and conduct age classification. We developed the first aging clock b...

Most previous epigenetic age predictors were focused on DNA methylation. Our own model suggested nucleosome positioning as an age predictor a year ago onlinelibrary.wiley.com/doi/full/10....

Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov

Grief Makes Us Time Travelers (Gift Article) A neuroscientist studying memory, I used to believe time was linear. Then my mother had a stroke.

As an oncologist, I get constant reminders that holidays are joyful & meaningful milestones, but not every yr & not for everyone. If you are with #grief, I hope this will remind you that you belong to something vast & are not alone.

#MedSky #OncSky #LongCovid

www.nytimes.com/2024/12/20/s...

The most complete collection of uniformly processed ChIP-seq data on identification of transcription factor binding sites for human and mouse. Convenient web interface with advanced search, browsing and genome browser based on the BioUML platform. gtrd.biouml.org/

💡 Why mentor with ASH?

• Inspire future hematologists
• Foster career growth
• Address workforce shortages

Apply by January 9: https://bit.ly/3VLCPwb

#ASHTrainee #Hematology #Mentor #HemeSky #Bloodsky 🩸

Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA

Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...

FDA grants accelerated approval The Food and Drug Administration granted accelerated approval to encorafenib.

The FDA has approved BRAFTOVI in combination with cetuximab and mFOLFOX6 for first-line treatment in patients with metastatic colorectal cancer with a BRAF V600E mutation. The approval is based on the BREAKWATER study, for which MD Anderson’s Dr. Scott Kopetz is co-PI. 1/2

🩸Erythropoiesis
#medsky #IMsky #internalmedicine #hemesky #hematology #heme #physiology #manualofmedicine

🩸Hematopoietic stem cell differentiation with cytokine regulation #hemesky #hemeonc #medsky #IMsky #internalmedicine #hemepath #pathsky #stemcells

💊 Chemotherapy: disrupting cancer cell cell growth and survival at multiple levels.

This handy diagram summarizes chemotherapy classes and where they fit according to their mechanism of action ⚙️

#oncsky #hemeonc #hemesky #pharmsky #medsky #IMsky #cancer #chemo
(Falzone et al., 2023. Cell)

🩸 Febrile Non-Hemolytic (FNHTR):
- Time: ≤ 4 hours
- Cause: cytokines in donor blood
- Prevention: H2 blockers, antipyretics, leukoreduction
- Mgmt: stop infusion, antipyretrics, H2 blockers, meperidine (rigors), r/o other causes, notify blood bank

#hemesky #medsky #IMsky #internalmedicine

🫀Cardiac tamponade vs constrictive pericarditis vs restrictive cardiomyopathy

A big thanks to #IMR for this handy comparison table. Good for reference down the road or for someone like myself currently studying for the #InternalMedicine Royal College exam here in Canada.
#cardiosky #medsky #IMsky

#ASHKudos to super talented MD/PhD student Amara Pang on her Graduate Award from @ash-hematology.bsky.social. She has launched a fantastic new project in the lab on Kit-mutant mastocytosis! #ASH24