New bioRxiv preprint from Pascal Maire’s group is out! I’m happy to have made a small contribution and to be included as a co-author.
“c-MAF transduces motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions” www.biorxiv.org/content/10.6...
#myoblue
Our mini-review on large Maf transcription factors—the principal regulators of fast-twitch myofibers that we identified—has just been published.
www.jstage.jst.go.jp/article/trs/...
Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans.
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
Our new review, “The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases,” is now available online in AJP Cell Physiol.
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social
Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma
www.frontiersin.org/journals/cel...
Our work provides the exciting possibility of reintroducing fast-glycolytic type IIb myofibers—long absent in humans—through the manipulation of large MAFs!!
I’d like to thank Dr. Pascal Maire and Dr. Stefano Schiaffino for their invaluable comments on our study prior to submission.
Moreover, collaboration with Ildus
@SportsGenomics
RNA-seq analysis of human muscle biopsies revealed a nice positive correlation between MAFA, MAF, and MYH4 expression, with these genes elevated in power-trained individuals.
Interestingly, type IIb myofibers are largely absent in the skeletal muscles of humans, despite their significant role in smaller animals such as mice. However, large MAF can reawaken evolutionarily dormant fast-glycolytic Type IIb myofibers in human skeletal muscle.
Building upon our previous study published in Cell Rep (10.1016/j.celrep.2023.112289), which identified large Mafs as essential regulators of type IIb myofiber specification in mice, this work extends our understanding to humans. biorxiv.org/cgi/content/...
#Myotwitter
