Vasily Zaburdaev

Dr. Stephanie Möllmert in her lab, smiling and looking trough a microscope.

Dr. Stephanie Möllmert looking at the camera.

Meet Dr. stephmoellmert.bsky.social – Curiosity as common thread

She aims to connect #biophysics with questions that matter for women’s health. With her passion for STEM biophysics was logical: physical concepts & precise measurement methods applied to living systems.
👉 mpzpm.mpg.de/research/ste...

The Biophysical World Inside a Jam-Packed Cell | Quanta Magazine Innovations in imaging and genetic engineering are coming together to probe the biophysics of cytoplasm inside living animals.

Density. Crowding. Tomato. Tomato 🍅

@gabepopkin.bsky.social kin.bsky.social @quantamagazine.bsky.social Thx for covering the debate! We promise we're all friends 🥰 @liamholt.bsky.social & @gwgl.bsky.social

Nothing would have been possible without @gucklab.bsky.social @vasilyzaburdaev.bsky.social

Just back from the annual meeting of the @dfg.de priority program #SPP2332 on "Physics of Parasitism", this time at the Robert Koch Institute at Berlin. So many great talks and discussions! Already looking forward to next year's meeting at Hamburg👍

Erlangen, Bavaria, Germany. Pixel 10 XL.

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes - Nature Communications Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure balance, and how deviations emerge during pathophysiological states like senescence.

Awesome work by the @simonereber.bsky.social, @vasilyzaburdaev.bsky.social & Guck labs (published in @natcomms.nature.com). They show that the nucleus is less dense than the cytoplasm and that the density ratio is conserved across many eukaryotes. www.nature.com/articles/s41...

A cell nucleus reconstituted in vitro in Xenopus laevis (African clawed frog) egg extract. Left image shows a fluorescence image where DNA has been stained and right image shows a density map of the same nucleus aquired using Optical Diffraction Tomography (ODT).

Researchers from #MPZPM and @mpiib-berlin.mpg.de have now compared the ratio of nuclear and cytoplasmic density in different organisms and come to a surprising conclusion: the cell nucleus in eukaryotes is less dense than the rest of the cell.

👉 mpzpm.mpg.de/news/news-de...

#Physics #Medicine

Indeed, fantastic job Dr. Tim Klingberg! Big thanks to @lennarthilbert.bsky.social for coming over to Erlangen @fau.de for the defense and for all continued years of collaboration that led to this!

What a great doctoral defense by Tim Klingberg @fau.de

Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”

Some impressions

Amazing to see this out, and surely this is only the beginning of many related phenomena to be understood and decipher the roles of density distribution inside cells! Congratulations to all involved!

Cell state-specific cytoplasmic density controls spindle architecture and scaling - Nature Cell Biology Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a det...

🍹Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control.
bit.ly/4mhMvsU

Cell state-specific cytoplasmic density controls spindle architecture and scaling Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨

👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

🚨🚨🚨 #PhD position available in @simonereber.bsky.social lab at @mpiib-berlin.mpg.de! World-class training to be had on #microtubule #cytoskeleton biology using #Xenopus & #microscopy readouts. 👇

Hierarchical Heterogeneities in Spatio-Temporal Dynamics of the Cytoplasm Understanding of the dynamics inherent to biological matter is crucial for illuminating the physical mechanisms underlying cellular processes. In this study, we employ bright-field differential dynamic microscopy (DDM) to investigate density fluctuations inherent in a cell-free model of eukaryotic cytoplasm. Our measurements reveal subdiffusive fractional Brownian motion and non-Gaussian displacement distributions, highlighting cytoplasmic heterogeneity. We introduce an empirical model that combines fractional Brownian motion with an inverse Gaussian distribution of diffusivities to describe the observed non-Gaussianity. Validated through Monte Carlo simulations, this model allows us to estimate the fractional diffusivity and exponent effectively. By altering macromolecular composition, the addition of energy, and assembly of a cytoskeleton, we identify three independent mechanisms that result in similar fractional exponents yet distinct diffusivities. We find that energy addition leads to non-stationary dynamics, in contrast to the stationary behavior observed under passive conditions. Presence of microtubules introduces a secondary dynamical timescale, which we describe using a two-state fractional Brownian motion model to differentiate between cytosolic and microtubule network associated contributions. Our findings demonstrate the effectiveness of DDM as a label-free tool for quantifying viscoelastic and heterogeneous properties of the cytoplasm and provide insights into how physical and biochemical factors, including cytoskeletal organization, govern subcellular dynamics. ### Competing Interest Statement The authors have declared no competing interest.

New insights in to the physical properties of the 🐸 #Xenopus cytoplasm!
Great work @mctwo.bsky.social & @biswashere.bsky.social!
Together with @gucklab.bsky.social & @vasilyzaburdaev.bsky.social 😍 @mpi-scienceoflight.bsky.social
@mpiib-berlin.mpg.de

www.biorxiv.org/content/10.1...

Beautiful work by @mctwo.bsky.social investigating the spatio-temporal dynamics of the cytoplasm using label-free tools and 🐸 extracts!

🐸 + 🔬 + 📈 = ✨

w. @gucklab.bsky.social , @simonereber.bsky.social , @vasilyzaburdaev.bsky.social

www.biorxiv.org/content/10.1...

Congratulations!!!

Happy International #WomenInScienceDay!

🚨🚨 MEGA JOB ALERT 🚨🚨
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!

Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏

More details below... check it out! 🧵 1/3

Resolving spatiotemporal dynamics in bacterial multicellular populations: approaches and challenges | Microbiology and Molecular Biology Reviews SUMMARYThe development of multicellularity represents a key evolutionary transition that is crucial for the emergence of complex life forms. Although multicellularity has traditionally been studied in...

Nice occasion for 1st post! Our contribution with Liraz Chai (not yet on 💙sky) to the review on modern methods to study #biofilms headed by Susann Müller (same) and members of #SPP2389 @emmanuel-saliba.bsky.social @knutdrescher.bsky.social @cyanolab.bsky.social
journals.asm.org/doi/10.1128/...