Miguel Ramirez-Otero

Scientific datasets are riddled with copy-paste errors Initial results from scanning through Excel files belonging to 600 published scientific papers.

Markus Englund built a tool for identifying repetitive sequences in scientific datasets! Read up here: www.sciencedetective.org/scientific-d...

Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
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PAF15–PCNA exhaustion governs the strand-specific control of DNA replication - Nature PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

A study published in Nature has identified a new mechanism that controls DNA’s ability to replicate – and thereby a cell’s ability to divide. A protein, PAF15, acts as the brake, preventing the replication machinery from becoming overloaded and protecting cells from replication catastrophe. 🧪

Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial
impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis.
#AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria

www.nature.com/articles/s41...

You are passionate about ubiquitin, proteostasis and cellular biochemistry and want to be part of a collaborative, ambitious, excited and fun team? I am recruiting PhD students via the @imprs-lm.bsky.social graduate school:
www.imprs-lm.mpg.de/index.php/le...
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Tomorrow (Tue 3rd)!
PLEASE NOTE THE ALTERNATIVE ZOOM LINK! 👇

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

Our Science paper is out! 😃

www.science.org/doi/10.1126/...

This just in. So honored and grateful...

Two new papers from the lab published in The EMBO Journal!

link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading

link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1

Trove of Mexican genomes could help guide prescribing decisions Study reveals role of “fine-grained” ancestry in predicting response to painkillers, statins, and other drugs

Trove of Mexican genomes could help guide prescribing decisions | Science | AAAS www.science.org/content/arti...

The new cover and feature @nature.com www.nature.com/immersive/d4...

Developing super-tortillas to address malnutrition in Latin America Mexican food scientist Raquel Gómez-Pliego works to improve the nutritional value of foods through microbial fermentation.

Developing super-tortillas to address malnutrition in Latin America www.nature.com/articles/d41...

New year, new preprint! 🎊

We are excited to share our recent work on #E3 ligase regulation in #metabolism!

www.biorxiv.org/content/10.6...

#ubiquitin #targetedproteindegradation #chemicalbiology

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🔍 #AskZebrafish: Does anyone in the US or Canada have any of the following mutant #zebrafish lines and would be willing to share?

tert, klotho, cxcl12a, cxcl12b, cxcr4a and cxcr4b

Any leads would be appreciated! (Yes, we know ZIRC has some frozen but trying to find live)

Have you ever thought to yourself, 'I wish I had a bibliography with 50 carefully arranged references, each one showing a different way AI is making everything worse, perhaps with selected quotations from each reference'? Do I have good news for you"

sharonkabel.com/genai-fraud

Check out the newest preprint from the Schulman lab 🎊🎉

Super cool mechanism of how a metabolite regulates the stability of its own metabolizing enzyme!

Alina did it all for this project CRISPR screen ✂️, biochemistry 🧪, and cryo-EM ❄️🔬.
Congrats!

Our latest paper on the molecular mechanisms of XPF-ERCC1 recruitment to SLX4-dependent DNA repair pathways has been published! Congratulations to first author Junjie Feng, and a heartfelt thank you to all our collaborators for their contributions to this study!
www.nature.com/articles/s41...

Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...

I was a ‘go, go, go’ academic. A fellowship abroad transformed my approach “I came back with a recalibrated sense of how I want to live and work,” this professor writes

I was a ‘go, go, go’ academic. A fellowship abroad transformed my approach | Science | AAAS www.science.org/content/arti...

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Our @costerlab.bsky.social review is out!

It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!

www.sciencedirect.com/science/arti...

@adityasethi.bsky.social @billiedelpino.bsky.social

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics

New York millionaires: threatening to flee the city since 2009

Five ways Joe Rogan misleads listeners about climate change  » Yale Climate Connections Rogan exposes millions to climate denial. Let’s break down his tactics. 

Joe Rogan spent a whole podcast episode spouting climate misinformation. @dananuccitelli.bsky.social broke down the tactics Rogan and other climate deniers use so you can call them out when you hear them.

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina!

www.nature.com/articles/s41...

Spotify is running ICE ads. I went to cancel on mobile and saw that this isn’t allowed on mobile. They make you cancel on desktop. You think that’s gonna stop me, Spotify? I will erase you and forget you ever existed.

THOU SHALT CANCEL SPOTIFY!!!

A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...

What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...

Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity Mutations in the ATRX chromatin remodeller predispose to a developmental genetic disorder and cancer, but how it safeguards genome and telomere stability remains unresolved. Here, we uncover critical ...

🧬 Preprint alert!

"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."

Read the manuscript here 👉 www.biorxiv.org/content/10.1...