Looking for a comprehensive review on the neuronal endoplasmic reticulum? Look no further! Our review just got published in Nature Reviews Neuroscience!

nature.com/articles/s41...

Huge thanks to my co-authors, Lia Carvalhais and @marijnkuijpers.bsky.social
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Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation Mitochondria are diverse and multifaceted intracellular organelles regulating oxidative energy supply, lipid metabolism and calcium (Ca2+) signaling. In neurons the spatial sequestration of cytoplasmi...

Check out our new preprint! We combine EM data, genetically encoded tools and single-cell electrophysiology to investigate mitochondria at the AIS, where they cluster and strongly buffer Ca2+. Surprisingly, they don't impact electrophysiological properties.
www.biorxiv.org/content/10.1...