Anna Molofsky Lab

IFN-brite: A new interferon reporter from our lab designed by Dr. Sarah Anderson is bright and pan cellular

Amazing story from @arimolofskylab.bsky.social led by the fearless @nathanec.bsky.social now online @nature.com

Nobel laureate on how Trump's cuts are hurting science Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...

I am saddened by this news. Atul was a vibrant colleague and tireless proponent of using data to unravel the complexity of disease.

Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples We recently described astrocyte pro-inflammatory epigenetic memory based on multiple complementary in vivo and in vitro studies, and the analysis of multiple sclerosis samples. Based on bioinformatic ...

New pre-print from our lab here:
www.biorxiv.org/content/10.1...

Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

Cross-regulation between the nervous system and type 2 immunity The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.

We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore!

Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠

Review @sciimmunology.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social @nickmroz.bsky.social @phagocyticpai.bsky.social
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...

Cross-regulation between the nervous system and type 2 immunity The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.

This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead

#neuroimmunology #allergy #Alzheimers #itch

Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social @

#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/

This was the last @hhmi.org conference Lilly and Yuh-Nung Jan attended as investigators. They're becoming HHMI emeritus but still run a thriving NIH-funded lab. From cloning the first potassium ion channel (Shaker) to decoding neuronal development, the Jans have made a huge impact.

The Department Of Health And Human Services Cuts 10,000 Jobs The cuts hit multiple agencies, affecting work on HIV, gun violence prevention, vaccines, minority health research, and more.

Thousands of federal health workers woke up on April 1 to find they had been fired or laid off. Scientists and civil servants at the FDA, CDC, and NIH were let go as part of Robert F. Kennedy Jr.'s pledge to cut jobs at the country’s most important disease-fighting agencies.

Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.

www.wired.com/story/doctor... “To get rid of 11 of our senior PIs … we’re hoping that’s a mistake, because we can’t figure out why they would want to do that,”

Removing the top leadership at NIAID, NIH and other health agencies, including the CDC and FDA, will damage America’s position as a leader in groundbreaking research in disease prevention and treatment. That puts us all at risk. Read our statement: asm.org/Press-Releas...

Read the Letter Researchers at academic institutions nationwide say that U.S. science is being dismantled.

www.nytimes.com/interactive/...

Interneuron-specific dual-AAV SCN1A gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome | Science Translational Medicine www.science.org/doi/full/10....

Go John and Boaz! new gene therapy for Dravet

Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner @cellcellpress.bsky.social @jonykipnis.bsky.social
www.cell.com/cell/fulltex...

Babies form fleeting memories The human hippocampus constructs short-lived memories from around 1 year of age

We have no memories for events from our earliest childhood years (aka infantile amnesia). Is it because we can't form them or can't keep them? Our Perspective on exciting new work from @tristansyates.bsky.social and colleagues.

Babies form fleeting memories | Science www.science.org/doi/10.1126/...

Stephanie Palmer on human speech, birdsong and a mentor A groundbreaking review by Allison Doupe, who was Palmer’s mentor, and Patricia Kuhl shaped the field of neural and evolutionary dynamics of speech.

“This review belongs in the canon of papers that inspire deep theory work,” writes Stephanie Palmer about a groundbreaking review by her mentor—Allison Doupe—and Patricia Kuhl that helped the field define the neural and evolutionary dynamics of speech.

#neuroskyence

Same in San Francisco

This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH

This is one of the best features I have seen on blue sky yet- a custom feed of papers from people you follow. I had to un-follow the various biorxiv channels, as it was dominant, but now I am seeing lots of cool papers from people I follow.

Great work on this feed, @paper-feed.bsky.social team!

Cartoon by @paulnoth.bsky.social

Where does TrumpElon think innovation for all their favorite biotech corporations comes from? PCR only exists because somebody was looking for bacteria in hot springs at Yellowstone. I’m just a private practice ophthalmologist who barely understands p values but even I know this shit is important.

As Cervical Cancer Deaths Plummet, Experts Credit HPV Vaccine HPV can cause a variety of cancers, including cervical. New mortality data for women under 25 point to the success of the HPV vaccine.

A recent study found that cervical cancer deaths in young women have plummeted since the introduction of the human papillomavirus vaccine.

Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time - Nature Neuroscience Sehgal et al. show that branch-specific dendritic plasticity mechanisms in the retrosplenial cortex link memories acquired close in time such that, unlike independent memories, linked memories are enc...

Dendrite specific linking of memories over time - a cool extension of the work from @sjo09.bsky.social, @denisejcai.bsky.social, and others:

www.nature.com/articles/s41...

#neuroscience 🧪

Stand Up for Science Rally Sees Mix of Science, Politics and Anxiety Thousands of protesters gathered in Washington for Stand Up for Science, a rally in response to President Trump’s federal-funding and job cuts.

Finally! www.nytimes.com/2025/03/08/s...

Agree! An honor to receive the Bowes award together with @kampmann.bsky.social - a testament to the incredible collaborations at @ucsfhealth.bsky.social that make our science possible!