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Sergio Menchero

@sermenchero

Postdoc at @crick.ac.uk | HFSP fellow | DevBio, epigenetics, marsupial, evo-devo | Previous Manzanares lab | #embryo2017 | (he/him)

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12.09.2024
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Latest posts by Sergio Menchero @sermenchero

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🚨 Job Alert - Please share! πŸ™

Interested in 3D gene regulation in development & evolution? πŸ€“πŸ§¬

πŸ’₯ Our lab at @cabd-upo-csic.bsky.social is expanding!

We’re recruiting:
βœ… PhD students
βœ… Postdocs
πŸ’»πŸ§ͺ Experimental or computational backgrounds welcome

πŸ‘‡ Details below

06.03.2026 10:14 πŸ‘ 22 πŸ” 20 πŸ’¬ 1 πŸ“Œ 4
Apply to become a Preprint Editor
Development

Apply to become a Preprint Editor Development

We are inviting experienced researchers to apply to become Preprint Editors, a new type of editorial role responsible for handling our 'In preprints' articles and forging links with preprint literature. #prepints

Learn more and apply before 30 March 2026:
journals.biologists.com/dev/pages/pr...

02.03.2026 14:55 πŸ‘ 12 πŸ” 16 πŸ’¬ 0 πŸ“Œ 1
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The molecular evolution of vertebrate organs Nature Ecology & Evolution - This Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms...

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here:
rdcu.be/e5EgU
#EvoBio #EvoDevo πŸŸπŸ¦ŽπŸ’πŸ¦‡πŸŠπŸ¦œ

25.02.2026 12:29 πŸ‘ 140 πŸ” 52 πŸ’¬ 2 πŸ“Œ 5
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🚨🚨 #Hiring!

Funded #phd position open in our lab @cabd-upo-csic.bsky.social to study the role of YAP1 and associated factors in #preimplantation embryo development.

πŸ“† Apply by 6th March 2026 Details below.

@sebioldev.bsky.social

Please RT!

20.02.2026 13:58 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer β€” get in touch! πŸ‘‡

18.02.2026 10:47 πŸ‘ 33 πŸ” 30 πŸ’¬ 2 πŸ“Œ 1

PDRA position still open in my lab for anyone who wants to solve some outstanding questions in limb development. We have a variety of models and approaches (everything from stem cells to chicks and catsharks). Please share!

16.02.2026 09:14 πŸ‘ 5 πŸ” 7 πŸ’¬ 0 πŸ“Œ 2
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Happy birthday @ucl.ac.uk #UCL200

11.02.2026 21:45 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Job alert! πŸ“£ I’m looking for a research assistant to join my new team @idrm.ox.ac.uk

Were using #zebrafish to understand gene-environment interactions that shape the heart πŸ«€generate natural diversity 🐸🐭 and contribute to congenital defects β€οΈβ€πŸ©Ή

Full info below, and please share! 🫢🏻

bit.ly/467TO0M

02.02.2026 14:01 πŸ‘ 34 πŸ” 22 πŸ’¬ 0 πŸ“Œ 1

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

29.01.2026 19:23 πŸ‘ 92 πŸ” 35 πŸ’¬ 3 πŸ“Œ 6
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The @neuroalc.bsky.social invites applications for two permanent research positions (CientΓ­fico titular @csic.es , Tenure-track) to build independent programs in a collaborative, international environment. We welcome applicants from all demographic backgrounds πŸ‘‡
in.umh-csic.es/en/ofertas/d...

09.01.2026 14:52 πŸ‘ 2 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1
Client Challenge

We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com!

Open access link: www.nature.com/articles/s41...

(1/9)

09.01.2026 14:42 πŸ‘ 36 πŸ” 12 πŸ’¬ 1 πŸ“Œ 2

Congrats Nacho and all!!

07.01.2026 21:16 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...

Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed JosΓ© Luis Gomez-Skarmeta: rdcu.be/eXX8l

07.01.2026 19:33 πŸ‘ 69 πŸ” 32 πŸ’¬ 7 πŸ“Œ 1
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Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com πŸŽ‰πŸŽ‰πŸŽ‰
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

15.12.2025 16:22 πŸ‘ 71 πŸ” 31 πŸ’¬ 6 πŸ“Œ 2

🍾🍾 amazing!

09.12.2025 19:54 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Want to image cells protecting the embryo during early development? We're hiring! 1 Postdoc, 1 PhD student, and 1 Research Technician. Come to Barcelona! www.embryobioimaging.com

09.12.2025 17:44 πŸ‘ 5 πŸ” 6 πŸ’¬ 0 πŸ“Œ 2

Really fun, indeed! Thanks, Miguel!

04.12.2025 12:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ”” Please share πŸ”” I have two open developmental biology/genetics/evo-devo PhD project vacancies for October 2026 start.

1 = 🐚 🐌 πŸ”¬(embryos!!)
β±οΈπŸ“† DEADLINE 15th DEC πŸ“†β±οΈ (competition)
sleightlab.com/vacancies/

2 = πŸ¦ͺ 🐌 🧬
β±οΈπŸ“† DEADLINE 14th JAN πŸ“†β±οΈ(fully funded)
sleightlab.com/phd-vacancy-2/

01.12.2025 18:55 πŸ‘ 6 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0

πŸ™ŒπŸ™ŒπŸ™Œ

02.12.2025 12:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks! And congrats to you as well!

02.12.2025 11:49 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social πŸ™Œ great #DevBio from @crick.ac.uk

02.12.2025 11:06 πŸ‘ 23 πŸ” 7 πŸ’¬ 4 πŸ“Œ 0

Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.

27.11.2025 14:18 πŸ‘ 8 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1
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LSI PhD programme | Living Systems Institute | University of Exeter

We are recruiting PhD students!

Two days left to apply for the LSI studentships - deadline Nov 26
www.exeter.ac.uk/research/ins...

and a few more for the SWBio studentships - deadline Dec 3
www.swbio.ac.uk/programme/pr...

Please repost or forward to prospective students that might be interested!

24.11.2025 15:19 πŸ‘ 4 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

Scientific journals: we don’t want you using generative AI because it makes shit up.

Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote

Same journal: AI cover art which makes no sense? Oooh!

23.11.2025 01:51 πŸ‘ 197 πŸ” 42 πŸ’¬ 5 πŸ“Œ 2

Our lab is actively looking for posdocs and there is NOW an Open Call for Postdoc contracts (3 years) here: www.aei.gob.es/en/announcem...

07.11.2025 15:24 πŸ‘ 7 πŸ” 15 πŸ’¬ 0 πŸ“Œ 1
Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb - Nature Communications Qu, Razmara et al. show that Gli1+ fetal cells give rise to long-lived cartilage progenitors in the long bones. While normally dormant until postnatally, they expand upon (and compensate for) growth p...

And the paper is finally out! Thank you to the reviewers for improving the content, and to everyone who contributed along the way. A very nice way of finishing the transition from Melbourne to Cambridge.

www.nature.com/articles/s41...

19.11.2025 21:59 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular πŸπŸŒ±πŸ„. www.nature.com/articles/s41... 1/9

18.11.2025 12:00 πŸ‘ 164 πŸ” 85 πŸ’¬ 7 πŸ“Œ 6
Poster advertising the 6th X-inactivation meeting from Oct 19-23 2026 in Sapporo, Japan. The organizers are Asato Kuriowa, Edda Schulz, Ikuhiro Okamoto, Rafael Galupa, Takashi Sado, Mitinori Saitou.

Poster advertising the 6th X-inactivation meeting from Oct 19-23 2026 in Sapporo, Japan. The organizers are Asato Kuriowa, Edda Schulz, Ikuhiro Okamoto, Rafael Galupa, Takashi Sado, Mitinori Saitou.

πŸ“£ SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social

17.11.2025 11:38 πŸ‘ 38 πŸ” 18 πŸ’¬ 1 πŸ“Œ 0
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🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply πŸ˜‰
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

15.11.2025 09:52 πŸ‘ 36 πŸ” 37 πŸ’¬ 0 πŸ“Œ 3

Exactly! It's great to see it's not a rare exception

13.11.2025 09:32 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0