Prasad Jallepalli, MD, PhD

agree but also struck by the imbecility

no one grants "unconditional surrender" to an enemy hellbent on extermination

this is unspeakably evil, absurd, and stupid

Hegseth is telling 90 million civilians that US (and Israeli?) forces are an existential threat to their lives

How is that supposed to help?

"L'homme est condamné à être libre; parce qu'une fois jeté dans le monde, il est responsable de tout ce qu'il fait."

"Man is condemned to be free; because once thrown into the world, he is responsible for everything he does."

J.-P. Sartre, Existentialism and Humanism (1946)

I freaked out a dear friend by explaining this bit of eschatology

Graham clings to the idea that Trump and Trumpism can be controlled and cajoled by party apparatchiks like himself

Stop Making Sense | Burning Down the House | Official Clip HD | A24 YouTube video by A24

youtu.be/3Z2LhwMprLQ?...

tonight's mood

As Lindsey Graham tried to sell Donald Trump on bombing Iran, he liked to play a little word-association game with the president. “I say Franklin Roosevelt, what do you say?” the Republican senator from South Carolina asked. The correct answer: “You have nothing to fear but fear itself.” As he ticked through memorable presidential phrases, Graham asked Trump what his phrase would be. Trump said he didn’t know, Graham recalled. “Keep protesting, help is on the way,” Graham suggested, referring to Trump’s social-media post in January urging Iranians to confront their government. Few people lobbied Trump to undertake the riskiest gambit of his presidency as effectively as the hawkish and persistent Graham, who over a decade has held a sometimes close, sometimes tumultuous relationship with Trump. Some Democrats and even Republicans point the finger at Graham, who they think goaded Trump into a Middle East conflict with little plan for how the situation will play out long term.

www.wsj.com/politics/pol...

this is a crazy anecdote/lede that highlights Graham's mediocrity and vanity

for all his flaws, Trump is a phrase maker par excellence

yet Graham imagines himself as Prof. Henry Higgins tutoring Eliza Doolittle in how to speak

Why the US Torpedo Attack on an Iranian Warship Matters, In Maps The US torpedoing of an Iranian warship in international waters off Sri Lanka’s coast signals an alarming turn in the war unfolding more than 2,000 miles (3,000 km) away in the Middle East.

The US torpedoing of an Iranian warship in international waters off Sri Lanka’s coast signaled an alarming turn in the war in the Middle East. These maps show how the conflict reached the Indian Ocean.

it may be a relic of my faith tradition –– the Gita is a dialogue between Arjuna (warrior) and Krishna (charioteer and incarnation of Vishnu the preserver) that is profoundly spiritual and moral yet set within a epic battle in which Arjuna must act from duty and not desire

Rep. Dan Crenshaw says culture of misinformation fueled his primary loss: "The truth didn't matter" The fourth-term congressman, who lost decisively to state Rep. Steve Toth, said baseless attacks about his alleged insider trading and gun stances fueled the upset. BY GABBY BIRENBAUM MARCH 6, 2026, 4:25 P.M. CENTRAL REPUBLISH SHARE

"Fire hurts," complains arsonist

www.texastribune.org/2026/03/06/d...

Page of forever stamps with a picture of Alex Trebek and a jeopardy style Answer reading “this naturalized US citizen hosted the quiz show Jeopardy! For 37 seasons”

Spouse who is an immigration lawyer just got the world’s greatest USPS forever stamps for his mail

this is what the same outlet put up on f***b***k

big if true

wtaf

I am comfortable agreeing, but for those who might hesitate, I would say that war must be the last option, never the first resort

minimizing pain and distress is a moral prerogative

glorifying war violates that dictum

BREAKING Iran's Revolutionary Guards say they are waiting for US forces to escort ships through the Strait of Hormuz, where traffic remains strangled as the war rages.

"We recommend that before making any decision, the Americans remember the fire of the American supertanker Bridgeton in 1987"

not sinking is good of course, but running into a mine that breaches the hull and spills oil sounds bad too

is Iran trying to say that the strait is booby-trapped with mines?

CBS obtained video of the DHS killing of an unarmed man in Texas that DHS concealed for nearly a year, which clearly contradicts claims that he violently rammed anyone. He is shot with his brake lights on, car not moving or barely moving. Another DHS crime.

Bodycam video contradicts ICE claims in fatal shooting of U.S. citizen Ruben Ray Martinez in Texas Video of last year's fatal shooting of Ruben Ray Martinez obtained by CBS News appears to contradict claims that Martinez was shot by an ICE agent because he "accelerated" and "intentionally ran over"...

DHS claimed "an ICE agent had fired 'defensive shots' into Martinez's vehicle after Martinez 'intentionally ran over' another agent."

But body cam video now "shows that Martinez's vehicle, a blue Ford Fusion, was stationary or going at a very low rate of speed when he was fatally shot."

apparently I'm not asleep so I downloaded and plotted the NIGMS data for 2024 and 2025

plot shows cumulative % funded by percentile

AUC is clearly lower (duh) but also lines don't cross

delta-AUC decreases as you go up in percentile

too late for me to give this a proper analysis, but what is striking to me is the much larger number of skips in the 1st decile but nearly constant pickups in the 2nd decile

I am certain NIGMS is aware of its donut hole problem regarding MIRA eligibility -- if you *had* an R01 and can't get it renewed because of the drawbridge being raised, you're SOL

that's a significant cohort of labs GM has invested in -- in some cases for multiple cycles

GM also skips more high-scoring applications than other ICs because of its well-funded investigator policy. That and other considerations make me hesitate to generalize from NIH-wide data much less bulk regression analyses. Waiting for @jeremymberg.bsky.social aka Datahound to weigh in.....

Updating: The woman is Sundas "Sunny" Naqvi, a current resident of Skokie who was born in Evanston

BREAKING: U.S. Customs and Border Protection detained three U.S. citizens and three Green Card holders, including an Evanston resident, at O'Hare Thrusday afternoon

At least one, an Evanston woman, is currently being held at Broadview's ICE facility, her sister told me

the entire speech is worth listening to, but this stopped me in my tracks:

"We see science and expertise being denigrated, while ignorance and dishonesty, and cruelty and corruption are reaping untold rewards.

Every single day we see that."

United States Onurt of Appeals FOR THE DISTRICT OF COLUMBIA CIRCUIT No. 26-5050 September Term, 2025 1:25-cv-02471-ACR Filed On: March 6, 2026 Fritz Emmanuel Lesly Miot, et al., Appellees V. Donald J. Trump, President of the United States of America, et al., Appellants BEFORE: Walker, Pan, and Garcia, Circuit Judges ORDER Upon consideration of the emergency motion for a stay pending appeal, the opposition thereto, the reply, the amicus briefs, and the Rule 28(i) letters, it is ORDERED that the motion for a stay be denied.

BREAKING: DC Circuit, on a 2-1 vote, keeps in place a lower court order blocking DHS Sec. Noem’s effort to end Haiti temporary protected status designation.

Judges Pan and Garcia deny DOJ’s request to stay the district court order. Judge Walker would have granted it.

Haiti TPS is safe for now.

a grievous self-inflicted wound that will take years to heal if at all

I keep thinking about this weird thing where the DOJ is investigating Jerome Powell for allegedly lying to the Senate about renovations (even though no senators have accused him of lying), while Kristi Noem told the Senate Trump approved her $220M ad campaign and Trump himself said that wasn't true.

demented

Trump has privately shown serious interest in U.S. ground troops in Iran The president’s private comments have not focused on a large-scale ground invasion of Iran, but rather on the idea of a small contingent of U.S. troops that would be used for specific strategic purpos...

When it's going as planned