Regina So

Another paper from our collaboration with Rob Britton’s lab! We’ve been focusing on novel methods to make nucleoside analogues for over 7 years now. This week we published our 2nd Science paper in the area. Congrats to the team! #MerckChemistry

www.science.org/doi/10.1126/...

Another amazing paper @judithagudo.bsky.social & friends, @nature.com! Metastasis & glucocorticoids 🤯 Check it out!! 👉 doi.org/10.1038/s415... 👇

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎

doi.org/10.1038/s420...

Now accepted @jacs.acspublications.org 🥳

pubs.acs.org/doi/full/10....

Cancer Glyco-X 2026: Intersections of Cancer and Glycoscience Join us for Cancer Glyco-X 2026: Intersections of Cancer and Glycoscience at Van Andel Institute Stay informed about exciting upcoming events and activities.

Check out this cool #glycotime conference @vai.org in May 2026, co-organnized by Sharon Pitteri @stanfordbiosci.bsky.social alongside Ginny Shapiro, Brian Haab, and Richard Drake.

www.vai.org/event/cancer...

GMP-manufactured medicinal product candidate composed of NK and γδ T cells as adjunct immunotherapy for hematopoietic stem cell transplantation
journals.sagepub.com/doi/10.1177/...

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons pro...

#EveryCellIsAnImmuneCell! Ugolini, Roger &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 activates sensory #neurons that produce the neuropeptide SP to limit neutrophil influx, & TAFA4 that drives IL-10 by macrophages, overall fostering disease tolerance!

Beautiful and solid work on trehalose monomycolate synthesis in mycobacteria by @figlegend.bsky.social lab. Check it out folks. Also, for the non-enzymologists, product inhibition is a thing, and actually does matter. 😜

www.pnas.org/doi/10.1073/...

#lipidtime

A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression An in vivo, noncanonical ferroptosis pathway, critical for tumor supression, is driven by reactive oxygen species-induced phosphatidic acid peroxidation at the ER under the control of the GPX1-OSBPL8 ...

#WeekendRead! #NoTimeToDie! Gu, Kagan, Xia &co show @cp-cell.bsky.social that ROS drive lipid peroxidation at the ER causing membrane rapture & ferroptotic death which is blocked by GPX1 recruitment via OSBPL8 to the ER & oxidized lipid reduction! Knockdown of GPX1/OSBPL8 blocks tumor growth!

16-h fasting regimen optimizes cancer immunotherapy by forcing metabolic trade-offs in tumor cells, increasing intratumoral isoleucine that fuels CD8+ T cell cytotoxicity via acetyl-CoA-driven epigenetic and lipid reprogramming
@cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...

Jennifer Doudna’s $1 Billion Plan To Bring Gene Editing To The Masses Crispr’s ability to cut genetic code like scissors has just started to turn into medicines. Now, gene editing pioneer Jennifer Doudna wants to build an entire ecosystem to bring these treatments mains...

“The best that I can do in terms of making the next breakthrough or discovery is not to do it by myself, but to enable other scientists to do it”
— Jennifer Doudna

www.forbes.com/sites/amyfel...

AlphaFold Database welcomes community datasets Latest AlphaFold Database update adds high-value datasets for microbial and viral proteins, generated by specialist communities

Delighted to see over 17 million new protein structure predictions from novel proteins in AllTheBacteria are now integrated into the AlphaFold Database at @ebi.embl.org !
Huge work from @gbouras13.bsky.social @oschwengers.bsky.social and friends to generate these.

www.ebi.ac.uk/about/news/u...

High-throughput ligand diversification to discover chemical inducers of proximity - Nature Chemical Biology Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into mol...

What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery.

More thoughts and details here: www.linkedin.com/posts/activi...

Paper here: www.nature.com/articles/s41...

Investigating Halogen Bonds as Pairing Force in an Artificial DNA Base Pair The past decades have seen significant expansion of the nucleic acid space with the development of modified artificial base pairs based on natural nucleic acid analogues and even entirely new designed base pairs. This expansion has led to tremendous potential for applications such as site-specific labeling and structural investigations. However, natural nucleic acids rely strongly on hydrogen bonding as the attraction force, which has driven the development of artificial base pairs that adapt this mechanism. To achieve orthogonality with natural bases, unnatural base pairs with alternative attraction forces, such as hydrophobic interactions, have been developed which however can perturb duplex structures. Our work introduces a completely newly designed artificial base pair that leverages halogen bonding (R–Hal···) as a directional hydrogen bonding-like interaction. We report computational studies that led to the development of this novel unnatural base pair and its synthesis. Our results demonstrate the successful acceptance of a bulky iodinated nucleoside triphosphate by KlenTaq DNA polymerase, enabling the selective enzymatic synthesis of a DNA strand containing the dIIPO–doIPP base pair. Our work presents the first demonstration of a novel base pair with halogen bonding potential that is enzymatically incorporated into DNA.

New paper in @jacs.acspublications.org 🎉:
A de novo designed unnatural base pair that exploits halogen bonding as pairing force in DNA for genetic alphabet expansion. 🧬 ⚗️
@unicologne.bsky.social
@chemunicologne.bsky.social
@breugstlab.bsky.social

pubs.acs.org/doi/abs/10.1...

#chembio and #bioorganic crowd: Registration to ESBOC is open. Join us on 27th-29th May for the oldest meeting in chemical biology in Europe, at the awesome Schlosshotel Pillnitz in Dresden!

Check out www.esboc.org.uk or register directly at eveeno.com/esboc2026!

Exciting new #glycotime work from the Woo lab @harvard.edu 👏

Our first venture into short peptide diversification is now online 😁 doi.org/10.26434/che...

#lcsojournalclub | LCSO Lab #LCSOJournalClub 216.1 (highlighted in picture) An amide bond formation promoted by trimethoxysilane reported by Hisashi Yamamoto and co-workers from Chubu University in JOC https://lnkd.in/dYaSPzgn 2...

edition 216 of #LCSOJournalClub
www.linkedin.com/feed/update/...

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24 and K565 have potential to...

#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...

📣 Thrilled to announce our incredible speaker lineup for the 2026 edition of #ETOC Online Symposium on April 29-30th.🗓️ Join us by registering today and to stay up-to-date! : tinyurl.com/ETOC2026-reg... (1/3)

Today is #WorldCancerDay

~1 in 5 people will develop #cancer in their lifetime

Each diagnosis affects not just one person, but families, communities, and futures

Grateful today for patients, clinicians, researchers & advocates - and to appreciate that progress depends on acting together

#WCD2026

Excited to share our latest preprint on work led by postdoc Robert Lusi (@rflusi.bsky.social)! Introducing ALTER (AGO-Led Targeted Editing of RNA) for non-downregulatory RNA manipulation by repurposing hAGO2, non-immunogenic and capitalizing on evolution. www.biorxiv.org/content/10.6...

#lcsosynthesisproblem #lcsosynthesisproblem | LCSO Lab SmI₂ enjoyers will not want to miss this week's #LCSOSynthesisProblem, where Najung challenged us to the total synthesis of Aberrarone by Xia, Ding, and co-workers. Check it out here 👉 https://lnkd.in...

And the next edition of #LCSOSynthesisProblem
www.linkedin.com/feed/update/...

Thiol-Free Sulfenylation Redefined: A Single-Atom Transfer Pathway to Symmetrical Di(hetero)arylthioethers via B(C6F5)3 Catalysis Diarylated thioethers are privileged scaffolds found across pharmaceuticals, functional materials, and molecular electronics. Conventional approaches to these motifs, typically via C–H functionalizati...

Congratulations to the team on our latest paper published in @jacs.acspublications.org @cardiffuni.bsky.social

pubs.acs.org/doi/10.1021/...

B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentia...

#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s

www.cell.com/cell/fulltex...

The last work of Clément TANGUY and Emma Robert on the formal total synthesis of Strictamine is now published in @helvchimacta.bsky.social !
onlinelibrary.wiley.com/doi/10.1002/...

Not new, but a new to us update:

The first preprint out of my lab! We joined forces with @kinasekid.bsky.social @jasonzxzhang.bsky.social and David Baker to study protein phosphorylation! Congrats to Isabella from my lab on her first first author paper! tinyurl.com/43jwwfua