Sharavan Vishaan V

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma Rade et al. present a longitudinal single-cell atlas of BCMA CAR-T therapy in multiple myeloma, revealing that cilta-cel drives potent CD4⁺ cytotoxic responses and superior outcomes. Their findings identify plasmacytoid dendritic cells as unexpected BCMA-expressing targets and suggest therapeutic potential in blastic plasmacytoid dendritic cell neoplasm.

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma

Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis Rheumatoid joints contain macrophages with reparative potential, yet inflammation persists. Huang et al. demonstrate that these homeostatic macrophages lose their protective role by undergoing PANoptotic death. Mechanistically, C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis. The resulting macrophage death amplifies autoimmune tissue inflammation through the release of pro-inflammatory mediators.

Online now: Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1 - Nature Cell Biology Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Mitochondria contact lipid droplets through the mitochondrial import complex binding to lipid metabolism enzyme Ayr1
👉https://rdcu.be/e7dRa
bit.ly/4baJZAO

A scalable, low-cost, sample hashing workflow for multiomic single-cell analysis using the Seq-Well S3 platform Nature Protocols, Published online: 06 March 2026; doi:10.1038/s41596-025-01308-8This Protocol presents a detailed guide for generating and analyzing single-cell multiomic data from low-input samples with the Seq-Well S3 platform.

New Article! A scalable, low-cost, sample hashing workflow for multiomic single-cell analysis using the Seq-Well S3 platform

Did you read our paper applying SUM-seq in macrophages, T-cells and iPSCs (www.nature.com/articles/s41...) and think: I want to try this cost-effective single cell RNA & ATAC-seq method myself? 🧬

Find the complete protocol including tips, troubleshooting and timing now in Nature Protocols

Review @cp-trendsimmuno.bsky.social
Secondary bile acids as immune and metabolic mediators
www.cell.com/trends/immun...

@biorxivpreprint.bsky.social Functional Type I and Type II interferon crosstalk restricts progenitor exhausted CD8 T cells through spatial exclusion and checkpoint enforcement
www.biorxiv.org/content/10.6...

Researchers praise ‘stunning’ results of new prostate cancer treatment Early trials of the drug VIR-5500 showed it shrinking tumours in some patients

📰NEWS: A new immunotherapy drug has shown promise for safely treating #ProstateCancer in a phase I trial led by researchers from the Drug Development Unit at the ICR and The Royal Marsden. #GU26

Read more in @theguardian.com ⤵️

www.theguardian.com/society/2026...

Open Access UCL Research: A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics discovery.ucl.ac.uk/id/eprint/10...

Thanks for sharing my work! Now available on UCL's open access repository.

EMBL International PhD Programme - summer recruitment 2026! 👀

Research groups across EMBL are recruiting now! www.embl.org/about/info/e...

Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research.

Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage Li et al. show that SPOP mutations and USP7 overexpression promote TREX1 upregulation, leading to increased cytosolic DNA degradation and suppression of cGAS-STING-mediated immune activation. Targeting USP7 enhances the effectiveness of radiotherapy combined with immune checkpoint blockade, providing a new strategy to overcome resistance and improve therapy outcomes.

Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

How Does Immunotherapy Help Us Treat Cancer? – with Samra Turajlić YouTube video by The Francis Crick Institute

How does immunotherapy help us treat cancer?
On World Cancer Day, join Crick group leader and clinical oncologist @Samra Turajlic as she discusses the successes and challenges of immunotherapy, as well as her team’s work to try and improve patient outcomes.

www.youtube.com/watch?v=r0ci...

Today, on #WorldCancerDay, the Government have published their National Cancer Plan for England.

Read our Chief Executive, Professor @helink.bsky.social view from the ICR and find the full National Cancer plan ⤵️

www.icr.ac.uk/about-us/icr...

Blue graphic with black text which reads, "World Cancer Day, 4 February"

In the UK, nearly 1 in 2 people will get cancer in their lifetime. Today is World Cancer Day – a global day to raise awareness of cancer, and take action against it 🌍

Share this post to help us raise awareness.

#WorldCancerDay #WCD2026

Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading

"Attention is the rarest and purest form of generosity."-Simone Weil

Polyamine-dependent metabolic shielding regulates alternative splicing - Nature Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Polyamine-dependent metabolic shielding regulates alternative splicing

www.nature.com/articles/s41...

My main PhD paper is finally out! 🎉

After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺.
@natimmunol.nature.com

It all started with an unexpected observation 🔍:
👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice.

1/11 🧵

☕Borsa et al. show that asymmetric #Tcell division after activation requires #autophagy to promote #mitochondria turnover, with T cells inheriting older mitochondria showing decreased degradation, reduced memory potential and altered metabolism.
bit.ly/458ODgL

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - Nature Metabolism The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.

RESEARCH | J Chilloux, @marcedumas.bsky.social et al. (Imperial College London)

The microbial metabolite TMA (precursor of TMAO) has beneficial metabolic and anti-inflammatory effects🧪

MetaboList – December 2025 Diet and cancer Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation Tong et al, Zhen Lei Hubing Shi ∙ Xuelei Ma. Dietary restriction…

Here’s a new compilation of papers about cancer metabolism published last month
MetaboList - December 2025

Special section about diet and cancer

metabolist.wordpress.com/2026/01/09/m...

Episode graphic titled “Can We Build A Human?” featuring several speakers and a large question mark background.

Could we build a human from scratch?

Join our expert panellists as they answer audience questions about lab grown organs, brain implants and synthetic DNA.

Listen now on your favourite podcast platform: lnk.to/AQOSBioengin...

Don’t miss Recent advances in reproductive immunology at #BSI25! Wed 3 Dec, 11:00–12:45, Room 3A.

Explore new insights into pregnancy, menstruation, endometriosis & cutting-edge immune research.

🔗 Full programme: https://bit.ly/4a5iBp1

Review @cp-immunity.bsky.social
A host-centric view of the microbiota metabolome
www.cell.com/immunity/ful...

Transparent artificial intelligence improves assessment of prostate cancer aggressiveness Until today, the aggressiveness of prostate cancer has been assessed primarily using the Gleason grading system—an analysis of cancer tissue in a pathology laboratory that is highly subjective. An int...

An international research team led by the German Cancer Research Center (DKFZ) has developed a novel, explainable AI model that aims to make the diagnosis of #prostatecancer more transparent and less susceptible to error. @natcomms.nature.com
t1p.de/losb0

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Nature research paper: Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

go.nature.com/479jKdH

Wellcome photography prize 2025 The Wellcome Photography Prize brings together visual stories of health, science and human experience.

Our new, free exhibition featuring shortlisted entries from the Wellcome Photography Prize opens tomorrow.

Stop by to experience stories of health, science and human experience captured in stunning photographs from around the world.

www.crick.ac.uk/whats-on/exh...

Thank you Anna Baulies Domènech and Abcam for inviting me to talk about my work at Cambridge.

🔬 I'm honoured to have been selected as a guest speaker.

#abcam #abscience #cambridge #science #research #immunology #metabolism #imaging #crick

You can read my work here: www.nature.com/articles/s41...