Rocio Sancho Lab

Implanted flexible electronics reveal principles of human islet cell electrical maturation Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We im...

www.science.org/doi/10.1126/...

Cyborg pancreatic islet organoids Bio-nanoelectronic islets are new tools for diabetes research and therapy

Wow! Cool paper! Cyborg pancreatic islet organoids | Science www.science.org/doi/10.1126/...

Congratulations to Rashmi and Karolina and also to the technology development studio of the MPI-CBG without whom the screen would not have been possible.
If you are interested in high-content screening in organoid models, you may want to take a look.

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhibitors, which, combined with FGF withdrawal, drive acinar cell differentiation, enabling future studies on these cells and their role in cancer initiation in humans.

Online Now! High-content screening of organoids reveals the mechanisms of human pancreas acinar specification #stemcells

Massive congrats to Dr Gehlen who absolutely nailed her viva and is already shining like the star she is ⭐ She is even wearing her PhD gift, a dryrobe that will keep her warm after swiming in freezing waters on her next adventure 🏊‍♀️❄️ #proud_sanchoLab🥹 @kingscollegelondon.bsky.social

Sancho Lab in full festive mode at the CGTRM Christmas department lunch... bright energy as the year closes, fantastic time with great food and good laughs all around!!! 🎄✨😄

Fantastic paper! Huge congrats 👏🥂

Fantastic Inaugural Lectures by Katie Doores and Patricia Barral
@barrallab.bsky.social . It is a real privilege to have colleagues like them at @kingslsm.bsky.social .

Human pancreatic organoids derived from pluripotent stem cells recapitulate pancreatic organogenesis https://www.biorxiv.org/content/10.1101/2025.10.31.685661v1

Generation of human iPSC-derived pancreatic organoids to study pancreas development and disease https://www.biorxiv.org/content/10.1101/2024.10.24.620102v1 The pancreas has vital endocrine and exocrine functions that can be affected by life-threatening dis

Generation of human iPSC-derived pancreatic organoids to study pancreas development and disease https://www.biorxiv.org/content/10.1101/2024.10.24.620102v1

Bonfanti and Sancho Lab | Dissecting disease-associated pathways and autoimmunity in type 1 diabetes and congenital hyperinsulinism using iPSC-derived beta cells and spatial multi-omics | Paola Bonfan... The 2026 #PhD recruitment at The Francis Crick Institute is now open! We are please to announce an additional opportunity to join our laboratory through a PhD project in collaboration with the Rocio...

www.linkedin.com/posts/paola-... Looking for a PhD? We are offering a project for the 2026 intake at the Crick!

Phd oportunity

Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social

www.colcc.ac.uk/2026-phd-pro...

crukradnet.colcc.ac.uk/phd-students...

✨A wonderful day of connection, insight, and inspiration at the BMBS PI Retreat. Grateful to all who shared their ideas and to Prof Rachel Tribe for closing the event with such energy and vision ✨
@kingscollegelondon.bsky.social

Had an amazing time at The CGT Circle Leiden ✨ Sharing my career journey with this incredible group was truly rewarding. Huge thanks to the organisers and to Sophia Kolbe for the invite 🙌 #NecstGen @kingscollegelondon.bsky.social @diabetesuk.bsky.social @ukri.org

We did it! 🌙✨ The Shine Night Walk was amazing and every step was powered by your support. Huge thanks to all who donated 🙏💙 What a night! 🎉👟 #ShineWalk @cancerresearchuk.org @kingscollegelondon.bsky.social

We did it! 🌙✨ The Shine Night Walk was amazing and every step was powered by your support. Huge thanks to all who donated 🙏💙 What a night! 🎉👟 #ShineWalk @cancerresearchuk.org @kingscollegelondon.bsky.social

Shiny Islets Cancer is happening right now, which is why we're fundraising right now for Cancer Research UK. There’s no time to lose! Donate today and help bring forward the day when all cancers are cured. Donatin...

The Sancho Lab is also joining forces in this beautiful initiative 🌟👟. Together, we are walking to support vital research 💖🎗️. Every donation, big or small, makes a difference 🙏✨. fundraise.cancerresearchuk.org/team/shiny-i... @kingscollegelondon.bsky.social @cancerresearchuk.org

Shiny Islets Cancer is happening right now, which is why we're fundraising right now for Cancer Research UK. There’s no time to lose! Donate today and help bring forward the day when all cancers are cured. Donatin...

The Sancho Lab is also joining forces in this beautiful initiative 🌟👟. Together, we are walking to support vital research 💖🎗️. Every donation, big or small, makes a difference 🙏✨. fundraise.cancerresearchuk.org/team/shiny-i... @kingscollegelondon.bsky.social @cancerresearchuk.org

Rocio - Shine Night Walk I am taking part in the Shine Walk in memory of my mother, who was my rock, the strongest guiding force in my life, who shaped who I am today and gave me the most powerful example to follow. She passe...

Walking through the night for Cancer Research UK 🌙✨ Every step helps beat cancer 💜 Please support with a donation if you can 🙏💫
fundraise.cancerresearchuk.org/page/rocios-...

Smiling faces after a delicious ice cream feast at Borough Market 🍦 wishing Vicky the very best with her MRes at Imperial, you will do amazing 🎉✨

Postdoctoral Research Associate in Robotics & AI

📣 Job alert! We are seeking motivated researchers to apply for a postdoctoral research associate position in #Robotics and #ArtificialIntelligence, funded by our new EPSRC project, Circular Robot 5.0!

More information: www.kcl.ac.uk/jobs/118605-...

Go Spagnoli Team, Goooo!!!! A por ello campeones!!! 👏💪👨‍🔬👩‍🔬🧫

Spagnoli Lab. One Walk Please help us raise vital funds for Breakthrough T1D, the leading global type 1 diabetes (T1D) research charity. Your support will help change the lives of everyone affected with T1D - Thanks so much...

We are doing it again!! 🚶‍♀️🚶‍♂️🚶🧪🧫🔬
For the Second Year My Lab is participating to the
One_Walk_London 🎡 to raise money for life-changing research & make a difference to T1D #diabetes
⤵️
support.breakthrought1d.org.uk/fundraisers/...

Please help us raise funds for @breakthrought1duk.bsky.social

We have a special episode out for you now, recorded live at #ISSCR2025!

Drs. Hongkui Deng and Candice Liew share the story behind their groundbreaking study transplanting CiPSC-derived islets into a patient with #Type1Diabetes.

Listen now: bit.ly/4n9c54K

Jenny Gehlen, final-year PhD student in the Sancho Lab, rocked her poster presentation at #ISSCR2025 in Hong Kong! Brilliant work, Jenny!✨🧫🧬🔬 @isscr.org @diabetesuk.bsky.social @ukri.org @kingscollegelondon.bsky.social

Live from #ISSCR2025! Prof Hongkui Deng reviewed chemical reprogramming for iPSCs, boosting efficiency & safety. Promising diabetes data! Strong talks on mechanisms & translation. More discussions ahead! @isscribe.bsky.social @diabetesuk.bsky.social @ukri.org @kingscollegelondon.bsky.social

🤩 Amazing start of the ISSCR experience! Great public symposium at the Hong Kong Science & Technology Park! 🧬🔬🧫👏🧑‍🔬 @kingscollegelondon.bsky.social @ukri.org @diabetesuk.bsky.social @isscr.org

🤩 Great talk by Jenny Gehlen at the BMBS PhD Symposium on how pancreatic stiffness influences beta cell differentiation. #ProudPI 🥹. Thanks to the organising team for such an amazing day! 🎉👩‍🔬🧫🔬👨‍🔬 @kingscollegelondon.bsky.social @diabetesuk.bsky.social @lido-dtp.bsky.social @lscn.bsky.social

Absolutely thrilled to be heading to #ISSCR2025 in Hong Kong this June! Looking forward to connecting with colleagues, who else is going? Let me know if you would like to catch up 🧫🔬👩‍💻

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system - Nature Materials A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administr...

BBB-crossing lipid nanoparticles to deliver mRNA to neurons and astrocytes, published at @naturematerials.bsky.social