Totally agree. It would be interesting to use this system to scale up the axon damage and see what the threshold is for broader impacts on oligodendrocyte homeostasis. Interestingly there was a small change in sheath extension for the remaining sheaths, even with the loss of one axon.
Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...
A #Dartmouth study in Nature Communications reveals that immune cells in the brain use a surprising two-step process to power their search-and-destroy missions: the brain’s emergency responders arrive powered by sugar, then build roads to recruit reinforcements for longer-term damage control.
New preprint from Xhoela Bame et al shows that dying oligodendrocytes stick around for weeks to months without mitochondria! This happens after single cell DNA damage or when mitochondrial Fis1 is deleted in oligodendrocytes.
www.biorxiv.org/content/10.6...
Alicia Pietramale et al. discovered a disconnection between microglial processes that surveil or respond to acute damage and those that contain mitochondria. Cytoskeletal components and metabolic enzymes underlie these differences. Final version just published!
www.nature.com/articles/s41...
My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social
My Department (Biology) at @dartmouthartsci.bsky.social is hiring this year! We have an opening for a Tenure Track Cell and/or Molecular biologist (broadly defined).
Please share with your trainees/labmates/friends and reach out if you have questions.
apply.interfolio.com/171625
We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...
Thank you @antferrui.bsky.social and @bobalhill.bsky.social for presenting their research at the recent Klingenstein Fellowship Awards in Neuroscience Conference.
📷 : SimonProPhoto
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
Yasmine Kamen's paper that establishes procaspase-3 as a marker for new oligodendrocytes was officially published and featured in This Week in The Journal.
Congrats to Yasmine and co-authors!
www.jneurosci.org/content/45/1...
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠
www.nature.com/articles/s41...
What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇
www.science.org/doi/full/10....
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
www.biorxiv.org/content/10.1...
This is great! Would appreciate being added.
