Kosaku Okamoto｜Pre-seniors × Digital Health

AXS-05 is under FDA priority review for Alzheimer’s agitation (decision goal: Apr 30, 2026). If approved, it may reduce reliance on PRN antipsychotics and physical restraints. Cobenfy is a non-dopamine drug approved for schizophrenia; Alzheimer’s psychosis is still Phase 3 (readout late 2026).

Japan is facing a dementia crisis – can technology help? Elderly people aged 65 and over now make up nearly 30% of Japan's population.

Japan's dementia safety measures are urgently needed: 19,039 dementia patients went missing in 2023, with 553 found deceased. Japan is advancing safety measures for daily life through GPS trackers, store/community alerts, AI screening, and robotic caregiving. 🔗 www.bbc.com/news/article...

A hidden Aloe vera compound takes aim at Alzheimer’s Scientists have uncovered promising clues that compounds found in Aloe vera could play a role in fighting Alzheimer’s disease. Using advanced computer modeling, researchers discovered that beta-sitost...

Aloe vera’s beta-sitosterol shows strong in-silico binding to AChE/BChE—an early drug-lead clue beyond amyloid. Computer models only; lab + human trials needed. However, this is still research-stage, so please avoid overhype or misuse. Supplements ≠ treatment. www.sciencedaily.com/releases/202...

Lifelong intellectual and social activities may delay onset: dementia by 5 years, mild cognitive impairment (MCI) by 7 years. It is important to incorporate hobbies and volunteer activities after age 60, not just education.
www.eurekalert.org/news-release...

Genes Are Not Destiny: What Nigeria and Okinawa Teach Us In my work in dementia care, I often hear families ask: “My mother had Alzheimer’s — does that mean I’ll get it too?”

I just published Genes Are Not Destiny: What Nigeria and Okinawa Teach Us medium.com/p/genes-are-...

The Key to Dementia Prevention: Combination and Sustainable Design “What works for preventing dementia? Tell me.”

Dementia prevention isn’t one program. Evidence points to multi-domain + sustainable design: a hub, fixed schedule, coaching, and hybrid online/on-demand + peer support.
medium.com/@kosaku.okam...

The Future of Senior Living Arrived at CES 2026 - K4Connect Discover the 5 key senior living technology trends at CES 2026 shaping the future of connected communities.

CES 2026: K4Connect showcased robotic companions for senior living. Pilot reports: less agitation, better mood + social engagement—especially for isolated residents or people with dementia—when integrated into wider engagement plans. #AgingTech #Dementia
👉 www.k4connect.com/the-future-o...

Cognition Therapeutics Publishes Phase 2 Clinical Results Showing Zervimesine’s Potential to Slow the Progression of Dementia with Lewy Bodies | Cognition Therapeutics, Inc. - Zervimesine exhibited meaningful improvement in behavioral, functional, cognitive, and movement measures compared to placebo -January 06, 2026 07:30 ETPUR ...

Cognition Therapeutics reported Phase 2 SHIMMER results for zervimesine (CT1812) in dementia with Lewy bodies: well tolerated, with favorable trends vs placebo in behavior, cognition, and daily function—suggesting potential to slow progression. #DLB #Dementia
👉 ir.cogrx.com/press_releas...

New Alzheimer Europe report projects 64% increase in dementia across Europe by 2050 On 28 January 2026, Alzheimer Europe launched the “The Prevalence of Dementia in Europe 2025” report, which provides updated prevalence figures for th

The Alzheimer Europe report forecasts that dementia cases in Europe will grow sharply by 2050 due to ageing populations. Numbers could rise by around 64 % from 2025 to 2050, increasing pressure on health, care and policy systems.
👉 www.alzheimer-europe.org/news/new-alz...

How Smart Diapers Are Transforming Dementia Support Excretion care is not “for caregiver convenience,” but care that protects dignity

Medium: medium.com/@kosaku.okam...
Spotify: open.spotify.com/show/05yMWId...

Smart diapers protect dignity in dementia care by reducing “open-and-check” inspections, so people aren’t exposed. They prioritize fast response to bowel movements and help protect sleep and comfort, reducing BPSD triggers.
#DementiaCare #CareTech #IncontinenceCare #BPSD #AgingTech

Tracing the Evolution of Dementia Villages: From De Hogeweyk to Agrace Dementia care has been shifting from “managing people for safety” to “building environments where a person can keep living.” A dementia…

Dementia care is shifting from “control for safety” to designing places where people can keep living ordinary lives.
I trace how dementia villages evolved—from De Hogeweyk to diverse global versions—into a broader, neighborhood-style approach.
#DementiaVillage
medium.com/@kosaku.okam...

An AI That Predicts Dementia Progression from Clinical Notes: What “Dementia-R1” Could Mean In early January 2026, a new AI approach drew attention for a simple reason: it aims to anticipate dementia progression earlier than we…

Clinical notes include signs like “missed meds,” “can’t manage money,” or “more bad days.” A new AI (Dementia-R1, Jan 2026) uses these notes—not just test scores—to flag faster decline earlier, helping families and care teams plan sooner.
medium.com/@kosaku.okam...

Alzheimer’s Disease and APOE: How Genetics May Point to New Treatment Directions In January 2026, reports suggested that APOE, a gene long discussed in Alzheimer’s research, may be involved in a larger share of…

Jan 2026: APOE is back in focus for Alzheimer’s.
Beyond ε4, even common ε3 may influence risk.
Because APOE affects lipids, inflammation, and vascular health, it may open therapy paths beyond amyloid.
medium.com/@kosaku.okam...

ChatGPT Health and Claude for Healthcare：What Will “AI-Mediated Healthcare” Change? In January 2026, the two major players in generative AI successively announced their “healthcare-specific” directions. One is OpenAI’s…

Jan 2026: ChatGPT Health + Claude for Healthcare highlight “AI-mediated care.” One translates records (RAG/FHIR); the other prioritizes safety (Constitutional AI). The shift isn’t automated diagnosis—it’s better prep and clearer patient-clinician conversations.
medium.com/@kosaku.okam...

AI Wearables and Dementia Support Can Brilliant Labs’ Frame / Halo Curb Veteran Talent Loss and Strengthen DX Organizations?

【AI Wearables for Dementia Support】

AI wearables may support dementia beyond treatment—helping with work, decisions, and communication.

Brilliant Labs’ Frame/Halo as “cognitive prosthetics” could reduce execution breakdowns and support autonomy.

The Great Debate Over the Brain’s “Glymphatic System” When Does Our Brain Get Washed?

What if the brain doesn’t clean itself mainly during sleep?

Recent neuroscience is challenging the long-held theory of the glymphatic system.
I summarize the growing debate and its implications for brain health and dementia.

medium.com/@kosaku.okam...

Solving Dementia Care Challenges: The Potential of “N-Body Problem” The field of dementia care now stands at a major turning point. Accelerating staff shortages, increasingly diverse frontline personnel, and…

Dementia care is at a turning point.

What if AI could help decide when and how much to intervene—without taking away autonomy?

I explored the potential of the N-Body Problem as a new paradigm for dementia care.

👉 medium.com/@kosaku.okam...