Barbara Mellone ๐Ÿ‡บ๐Ÿ‡ฆ's Avatar

Barbara Mellone ๐Ÿ‡บ๐Ÿ‡ฆ

@centromellone

Professor studying how genetic information is passed down to the next generation | She/Her | ๐Ÿ‡ฎ๐Ÿ‡น expat in the ๐Ÿ‡บ๐Ÿ‡ธ | Wannabe ๐ŸŽ rider | She/her | Posts and likes=mine

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Latest posts by Barbara Mellone ๐Ÿ‡บ๐Ÿ‡ฆ @centromellone

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U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office A Science analysis reveals how many were fired, retired, or quit across 14 agencies

The U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office.

A Science analysis reveals how many were fired, retired, or quit across 14 agencies. Read more: https://scim.ag/4boPkq8

28.01.2026 17:31 ๐Ÿ‘ 452 ๐Ÿ” 319 ๐Ÿ’ฌ 15 ๐Ÿ“Œ 34
NIH Data Book

The plot is only part of the story.

The data do not include lost science via terminations, freezes, stalled payments, and award delays. The collapse in awards rates will lead to job loss, gaps in research programs, and drive scientists to spend more time writing grants rather than doing science.

07.03.2026 01:59 ๐Ÿ‘ 84 ๐Ÿ” 23 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

07.03.2026 01:59 ๐Ÿ‘ 677 ๐Ÿ” 413 ๐Ÿ’ฌ 19 ๐Ÿ“Œ 61

I get yelled at for saying this but for many hundreds of years people went to university not to get diplomas or be employable but because immersion in the humanities was considered foundational to a good life, and school must return to its original purpose: the joy of learning.

08.03.2026 00:22 ๐Ÿ‘ 12126 ๐Ÿ” 2651 ๐Ÿ’ฌ 227 ๐Ÿ“Œ 186

The Nelson lab is presenting at #Dros26 today!

Stop by Daisy's poster to learn about rDNA instability in somatic aging (680F), and Caroline's poster about the role of an mRNA binding protein in regulating germline rDNA expansion (777F)!

06.03.2026 16:53 ๐Ÿ‘ 8 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Why propose a topic for one of our Workshops?
Why propose a topic for one of our Workshops? YouTube video by The Company of Biologists

Getting involved as an organiser of one of our Workshops is easy. We focus on the logistics, so you can focus solely on the science. Watch this video to hear from some of our previous organisers. The call for proposals for 2028 programme runs until 29 May. www.youtube.com/watch?v=eShr...

05.03.2026 09:39 ๐Ÿ‘ 7 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

idk that seems to be the understatement of the week. this is actually happening, postdocs and RAs are being let go, and projects falter. 'could face funding gaps'? this is actually happening at a large scale. 'Worry' doesnt reflect the existential crisis that many of my colleagues are in.

03.03.2026 17:37 ๐Ÿ‘ 46 ๐Ÿ” 17 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 0

Spent four hours in the ER with my daughter (she's fine!) and overheard the patient on the other side of the little curtain -- a college student freaking out because she has midterms and can't waste time getting treated.

Students, take care of yourself. I promise you, your profs will understand.

04.03.2026 01:13 ๐Ÿ‘ 1557 ๐Ÿ” 108 ๐Ÿ’ฌ 58 ๐Ÿ“Œ 10

Iโ€™m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

25.02.2026 16:53 ๐Ÿ‘ 70 ๐Ÿ” 18 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
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Private money cannot replace public funding of science Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public Healthโ€”particula...

"Private money cannot replace public funding of science"
Thank you @naomioreskes.bsky.social
www.science.org/doi/10.1126/...
๐Ÿงช ๐ŸŒŠ โš’๏ธ #scipol

27.02.2026 19:46 ๐Ÿ‘ 199 ๐Ÿ” 93 ๐Ÿ’ฌ 6 ๐Ÿ“Œ 8
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White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isnโ€™t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. ๐Ÿงต๐Ÿ‘‡

27.02.2026 16:06 ๐Ÿ‘ 1055 ๐Ÿ” 711 ๐Ÿ’ฌ 20 ๐Ÿ“Œ 75

I mean, it's this, or we just send chatbot-written e-mails back and forth to each other forever

27.02.2026 23:39 ๐Ÿ‘ 675 ๐Ÿ” 59 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 5

Excited to present our work on a novel centromere-targeting metazoan retroelement next Tuesday March 3 at 11am US East Cost time!

26.02.2026 17:08 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I understand why chatbot cheating happens but every time I read about it I want to gently remind everyone that the point of schoolwork is not for the submission to exist. Teachers are not just greedy for more essays or solved equations. The point is to do the work WITH YOUR OWN BRAIN, FOR LEARNING.

24.02.2026 19:37 ๐Ÿ‘ 3711 ๐Ÿ” 863 ๐Ÿ’ฌ 100 ๐Ÿ“Œ 49
Video thumbnail

This is hilarious and now Iโ€™m kind of glad I screen recorded the site yesterday. I especially love that they deleted the โ€œWill my professor know?โ€ question.

25.02.2026 21:03 ๐Ÿ‘ 90 ๐Ÿ” 28 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 4

Since yesterday, the Einstein AI cheatbot website underwent some rebranding. The tagline changed from "Einstein does the busywork so you don't have to," to "Einstein is the personal tutor every student deserves." In the FAQ, "How does Einstein do all this?" became "How does Einstein help me learn?"

25.02.2026 20:46 ๐Ÿ‘ 312 ๐Ÿ” 105 ๐Ÿ’ฌ 20 ๐Ÿ“Œ 15

There are real issues higher ed needs to address, but the outrage porn that you see on social media, Fox, etc. is just not at all typical

24.02.2026 23:17 ๐Ÿ‘ 136 ๐Ÿ” 54 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 2
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related โ€˜proto-pointโ€™ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with retrotransposon-rich centromeres and that long-terminal-repeat retrotransposons are the genetic substrate.

Nature research paper: Ancient co-option of LTR retrotransposons as yeast centromeres

go.nature.com/4c3kP9A

24.02.2026 09:35 ๐Ÿ‘ 12 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I'm constantly trying (/failing) to get this point across.

If you're a trained expert in a field, then it may be worthwhile to question the scientific consensus of your peers.

If you're not, the scientific consensus is absolutely the best you can do and it's arbitrary foolishness to disregard it.

24.02.2026 16:04 ๐Ÿ‘ 3761 ๐Ÿ” 853 ๐Ÿ’ฌ 54 ๐Ÿ“Œ 50

what even is the fucking point

23.02.2026 15:34 ๐Ÿ‘ 2867 ๐Ÿ” 724 ๐Ÿ’ฌ 213 ๐Ÿ“Œ 297

The fundamental premise behind AI-enabled cheating is that coursework is merely busy work, because your'e just doing it for professors.

We would never say that showing up for football practice is merely busy work because you're just doing it for your coaches.

23.02.2026 15:51 ๐Ÿ‘ 159 ๐Ÿ” 56 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 4

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila.

Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and
@buszczaklab.bsky.social!

www.biorxiv.org/content/10.6...

23.02.2026 01:43 ๐Ÿ‘ 74 ๐Ÿ” 38 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 2

We have almost zero custodial staff at IU. The uni put shovels in dorms after the last winter storm so students could clear snow. Our retirement was cut 10% last summer. We are continuously told to brace for unprecedented budget cuts. Tenure is gone.

But yeah, football.

21.02.2026 19:45 ๐Ÿ‘ 24 ๐Ÿ” 8 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1

Fellowship application dealdine for students from low income countries ๐ŸŒwill be in 1๏ธโƒฃ week.
Dont miss out on this opportunity ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! โžก๏ธUnique opportunity ! 15 exiting days โž• Daily high profile lectures.
๐Ÿ‘‰ bit.ly/4oGDR8f

20.02.2026 10:34 ๐Ÿ‘ 7 ๐Ÿ” 11 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

How does the piRNA pathway solve the self vs. non-self problem? ๐Ÿงฌ

Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

13.02.2026 15:11 ๐Ÿ‘ 90 ๐Ÿ” 51 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 4
Post image

New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes โ€œmulti-way regulatory hubsโ€ in early Drosophila embryos.
www.biorxiv.org/content/10.6...

05.02.2026 10:56 ๐Ÿ‘ 39 ๐Ÿ” 16 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

NSF GRFP applicants (and mentors): Was your application Returned Without Review and deemed ineligible despite fitting in the allowed topics?
1) Write NSF
2) Write your Congressperson
3) CC us at grfp@grant-witness.us so we can compile + follow up

Details and template at grant-witness.us/grfp-letter

02.02.2026 17:58 ๐Ÿ‘ 159 ๐Ÿ” 199 ๐Ÿ’ฌ 6 ๐Ÿ“Œ 17

Step 1: seed public distrust on vaccines with misinformation
Step 2: dismantle medical system supporting vaccines
Step 3: blame public distrust

03.02.2026 21:40 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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N.I.H. Worker Who Criticized Trump Seeks Whistle-Blower Protection

The #NIH is awesome. We're proud to work with @jenna-m-norton.bsky.social . #BethesdaDeclaration #strongertogether #fedstrong #NIHStrong

02.02.2026 23:25 ๐Ÿ‘ 19 ๐Ÿ” 8 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1