Tarika V

🍔 Dairy and meat dominated the research themes for 2025

🫛 Soy and peas were the most researched ingredients

📈 Emerging trend: functional & non-alcoholic plant-based beverages gaining momentum.

#plantbased #alternativeprotein #altprotein

Q1 2025 #Plant-Based Sensory Research:

🇺🇸 US publications increased 400% compared to Q1 2024. ~30% of studies focused on consumer perception.

Vow's Cultivated Quail Receives Approval From Food Standards Australia New Zealand - vegconomist - the vegan business magazine Australian cultivated meat company Vow is one step closer to launching cultivated quail in its home country after the product received approval from Food

Vow's cultivated quail product, which has been available for >1 year in Singapore, has a greenlight on safety from Australia/New Zealand regulators

Barring any changes within a 60 day review period, Vow will be permitted to sell cultivated meat in Australia/NZ

vegconomist.com/meat/vows-cu...

Q1 2025 #plant-based research:

⚙️ Sector: Processing & Formulation

🇨🇳 China saw a 33% increase in novel publications vs. 2024.

🌱 Key research trends include 'rheology' and 'high-moisture extrusion' for food texture, alongside increased focus on bioactive compounds for nutrition and health

A) Publications stats in #cellag by ingredient type

B) Compared to 2021, in the food tech sector, the number of published research papers in CM increased by ~200% and ~70% for PF/R.

#cultivatedmeat #precisionfermentation #recombinantproteins #recombinantfats #consumerperception

Cultivated Meat Q1 2025 publications: Research models

🐄 Studies using bovine cell lines were the highest (9 publications), followed by pig 🐖 (7) and mouse 🐁 (4)

🔬 Of the different cell types, satellite cells were the most researched (7), followed by myoblasts (6)

#precisionfermentation #syntheticbiology #cellularagriculture

🫧 PF is an established tech for enzyme production, however, it is still considered an emerging category in the food & deep tech realm.

⚠️ Thus, keyword searches for 'precision fermentation' yield limited results. Broadening search terms can further improve its research landscape analysis.

Precision Fermentation Q1 publications 2025:

Compared to 2024, there has been a 120% in the keyword 'precision fermentation' in Pubmed searches.

2025 publications are mostly review papers (7 out of 9) with two papers released from the US and Netherlands 🇺🇸🇳🇱

Of which, research themes included strain and protein expression efficiency, organoleptic advancements and a critique on the safety of PF products
🦠🔬

#cultivatedmeat #cellularagriculture #syntheticbiology #alternativeprotein #smartprotein

Cultivated Meat Q1 2025 publications: Research models

🐄 Studies using bovine cell lines were the highest (9 publications), followed by pig 🐖 (7) and mouse 🐁 (4)

🔬 Of the different cell types, satellite cells were the most researched (7), followed by myoblasts (6)

With $10M in Public Funding, South Korea to Open First Dedicated Cultivated Meat Centre South Korea's Uiseong County will build a cultivated meat R&D centre with $10M in government funding, as part of the country's food tech drive.

South Korean government invests ~$10M in new research center for #cultivatedmeat, which will be a testbed for >10 companies

This is how you develop a new industry

www.greenqueen.com.hk/south-korea-...

#cultivatedmeat #cellularagriculture

Nattokinase as a novel food-grade enzyme for long term cell subculture Cellular agriculture and regenerative medicine strive to replace animal-derived products in their processes as much as possible. In these efforts diss…

2025: GRAS-certified Nattokinase, a Bacillus subtilis byproduct, was used as a cell dissociation enzyme for bovine and human cells in culture media. It performed comparably to animal-derived trypsin - at a fraction of the cost.

Link to the paper: www.sciencedirect.com/science/arti....

Targeting myostatin using quercetin as a media supplement to improve myogenesis for cultured meat production: An in silico and in vitro study Cultured meat (CM) is an alternative protein food and is produced by cultivating muscle satellite (stem) cells (MSCs) derived from livestock animals (…

Unique research publications:

2024: Quercetin as a myogenesis promoter in culture media not only maintained media pH but also increased myotube thickness and aided in cell differentiation.

Link to the paper: www.sciencedirect.com/science/arti...

#CultivatedMeat Q1 2025 vs Q1 2024 publications:

Increase in cell media studies, ⬆️ by 133%

~36% of cell media papers were researched in S. Korea 🇰🇷

#cultivatedmeat #cellularagriculture #syntheticbiology #smartprotein #alternativeprotein

Q1 2025 Cultivated Meat publication findings:

Total no. of publications went from 27 (Q1 2024) to 46 (Q1 2025), a 70% increase

Novel technical research publications went from 15 to 22, a 46% increase

S. Korea published the most technical papers in 2025 (13), followed by China (7) and the US (4)

#precisionfermentation #cellularagriculture #syntheticbiology #petfood

Safety and Digestibility of a Novel Ingredient, Brewed Lamb Protein, in Healthy Adult Dogs - PubMed Protein production through precision fermentation is an attractive option to reduce animal use in food production. This study focused on the safety and digestibility of food containing a test ingredie...

Link to the study:

pubmed.ncbi.nlm.nih.gov/39943197/

🔗

A 15-40% inclusion rate seems safe for this study. Researchers indicate future work to cover:

- Testing different dog breeds (not just beagles)

- Investigating short-chain fatty acid production & its role in gut health

- Exploring global serum & fecal metabolite changes

🐕🦮🐩🐕‍🦺

- Fibre intake was increased that likely led to lower fat digestibility

- Protein & energy digestibility remained unchanged

- Fecal scores & pH changes suggest higher fiber content, leading to slightly softer stools (yeast based diet)

💩

- Whole blood taurine was lower in test groups but remained above the critical threshold (150 nmol/mL)

- Researchers link this finding to prior studies showing that lamb-based diets naturally lower taurine

🦴

- Nutrient profiles for all studies were similar, except crude fiber, which was reduced in the 40% cohort

- Body weight and condition did not differ across the study

- Metabolic, immune and kidney markers remained within the healthy range

🐶

- Liver health marker ALT (alanine aminotransferase) increased in some dogs, but this was likely linked to medications and not the test ingredient

- Cholesterol levels were lowered in 40% test ingredient cohort

🐾

How safe is brewed protein for pet consumption?

A 6-month-long study examined the safety of a novel yeast-brewed lamb protein at different inclusion levels (0%, 15%, 30% and 40%) in 40 healthy dogs 🐕

👇 The findings:

Optimizing ER stress responses could unlock higher yields and further reduce production challenges in plant-derived biopharmaceutical products.

🔗pubmed.ncbi.nlm.nih.gov/38038125

When producing mAbs (mAb1 & mAb2), the protein causing stronger ER stress led to necrotic symptoms and poor yields. This highlights the need to manage ER stress for efficient plant-based protein expression. 🌟

ER stress during heterologous protein production triggers the unfolded protein response (UPR), which can lower yields if unresolved. A study using N. benthamiana shows how transiently expressed H5 proteins reveal this mechanism. 🧬