@cannabisjrnl
Cannabis and Cannabinoid Research is the premier peer-reviewed journal dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and the endocannabinoid system.
⚖️ CBD for endometriosis pain?
In a triple-blind RCT, CBD oil was not better than placebo for postoperative chronic pelvic pain. Both groups improved, but CBD had more mild side effects.
A reminder of why rigorous trials matter.
📄 doi.org/10.1177/2578...
#Endometriosis #CBD #ClinicalTrials
🧠 Why averages fall short in medicinal cannabis research
New framework argues that context matters—patients can be responders and non-responders depending on time, situation, and outcome. Especially true for quality of life in palliative care.
📄 doi.org/10.1177/2578...
#MedicinalCannabis
🚨 Prenatal cannabis use & immunity
Urine-verified cannabis use during pregnancy was linked to suppressed maternal cytokines—both pro- and anti-inflammatory.
Raises questions about immune regulation during pregnancy and downstream birth outcomes.
📄 doi.org/10.1177/2578...
#Cannabis #Pregnancy
🌱 Cannabis “waste” isn’t waste.
New review of 262 studies shows industrial cannabis byproducts → textiles, bioplastics, biofuels, foods, cosmetics.
Big promise for the circular bioeconomy—policy just needs to catch up.
📄 doi.org/10.1177/2578...
#IndustrialCannabis #CircularEconomy
🐀 Tolerance without withdrawal.
Repeated THC injections produced clear tolerance in male and female rats—but no measurable spontaneous withdrawal, even using sensitive, continuous activity measures.
🔗 doi.org/10.1177/2578...
👵🏽👨👩👧 Who’s using cannabis—and why?
Among Californians 50+, informal care partners were more likely to use cannabis than noncaregivers—especially those caring for someone with dementia.
🔗 doi.org/10.1177/2578...
🍬 CBD gummies ≠ what the label says.
Lab testing of 56 products found:
• 70% mislabeled CBD dose
• 39% contained Δ9-THC
• Large variability within the same bottle
Regulation matters.
🔗 doi.org/10.1089/can....
💊 New clinical PK study (in advanced cancer):
A novel orobuccal nanoparticle formulation (NanoCelle™) delivered:
• CBD bioavailability: 10%
• THC bioavailability: 27%
≈ 2× higher than traditional oromucosal formulations
🔗 doi.org/10.1089/can....
🧒 New pilot RCT in adolescents with Tourette syndrome (FREE access):
• Double-blind, placebo-controlled crossover
• THC/CBD medicinal cannabis
• Feasible, acceptable, and safe in this small sample
Larger trials now needed.
🔗 doi.org/10.1089/can....
⚖️ As cannabis vaping becomes more common, delivery details matter.
This study shows carrier oil, age, and sex shape THC pharmacokinetics and acute effects in mice—highlighting the need for standardized, translational exposure models.
📄 Volume 10, Issue 6
🔗 doi.org/10.1177/2578...
🧴🍫 CBD products often miss the mark.
Testing of 97 hemp-derived haircare, cosmetic, and edible products found:
• Only 13% accurately labeled
• 10 products contained no CBD
• Many made therapeutic or “health halo” claims
🔗 doi.org/10.1089/can....
🧴🍫 CBD products often miss the mark.
Testing of 97 hemp-derived haircare, cosmetic, and edible products found:
• Only 13% accurately labeled
• 10 products contained no CBD
• Many made therapeutic or “health halo” claims
🔗 doi.org/10.1089/can....
🧠 Cannabinoids & anxiety-related disorders - a systematic review:
• Pharmaceutical-grade CBD and Δ9-THC show potential
• Mixed formulations don’t
• Study quality + sample sizes remain major limitations
More rigorous trials needed.
📄 Volume 10, Issue 6
🔗 doi.org/10.1177/2578...
🧠 Cannabinoids & anxiety-related disorders - a systematic review:
• Pharmaceutical-grade CBD and Δ9-THC show potential
• Mixed formulations don’t
• Study quality + sample sizes remain major limitations
More rigorous trials needed.
📄 Volume 10, Issue 6
🔗 doi.org/10.1177/2578...
Welcome Kevin P. Hill, MD, MHS as Associate Editor (Reviews) for Cannabis and Cannabinoid Research!
Harvard addiction psychiatrist advancing rigorous cannabis science. Fun fact: proud dad of two + 50+ marathons 🏃
🚨 New resource for cannabis & cannabinoid researchers!
The Resource Center for Cannabis & Cannabinoid Research (R3CR) is a new hub helping scientists navigate regulations, access high-quality materials, and build strong proposals.
Led by experts from UM, USP & WSU.
More: r3cr.org | LinkedIn @R3CR
🏅 Editorial leadership matters
Shout-out to our Top 5 editors (by papers handled) in 2025.
Your expertise keeps the journal moving—and improving.
#Editors #ScholarlyPublishing #TeamScience
🙏 Thank you, reviewers
Our reviewers of 2025 went above and beyond to ensure rigor, fairness, and quality.
Peer review makes science stronger.
#PeerReview #ReviewerAppreciation #AcademicCommunity
⬇️ What readers downloaded most
The Top 5 most-downloaded articles of 2025 highlight the topics resonating right now.
Thank you for reading, sharing, and citing.
#TopDownloads #OpenScience #JournalHighlights
📈 What readers cited most in 2025
Our Top 5 most-cited articles (published across multiple years) shaped the field this year.
#MostCited #ResearchTrends #ScienceThatMatters
📝 A productive year
In 2025, we published 80 papers spanning basic, clinical, and translational research.
Grateful to our authors for trusting us with your work.
#AcademicPublishing #ResearchImpact #2025Recap
📊 2025 by the numbers
Our 5-year Impact Factor: 3.5
Thank you to the authors, reviewers, and editors advancing rigorous, high-impact science.
#JournalStats #ImpactFactor #Research2025
🧠🍪 New study: Oral THC (dronabinol) boosts pleasure responses to sucrose & alcohol and reduces aversion to bitter tastes in rats. Repeated THC also lowers CB1 receptors in the dorsal hippocampus.
💡THC may enhance hedonic value and influence alcohol-cannabis interactions.
📘 doi.org/10.1177/2578...
🧪🥦 New pilot study: Short-term, low-dose CBD (30 mg twice daily for 4 weeks) did not improve glucose tolerance, alter the gut microbiome, or reduce inflammation in sedentary adults with overweight/obesity.
📘 Open access: doi.org/10.1177/2578...
🍼🧠 New study: Alcohol dilates fetal brain arteries in a region- & sex-specific way—through CB1 cannabinoid receptors.
Alcohol’s effects occurred without changes in endocannabinoids, suggesting CB1 activation is direct.
Important insight into prenatal alcohol exposure.
📘 doi.org/10.1177/2578...
🧠🌿 New editorial: Cannabis use is rising fast among adults 50+, but research in aging brains is scarce.
Aging affects cognition, metabolism & the eCB system—potentially increasing THC’s risks.
We urgently need studies focused on older adults.
📘 doi.org/10.1177/2578...
🩺 New trial: CBD raises anandamide but not 2-AG—yet these changes don’t explain its blood pressure–lowering effects. Mechanism still unclear.
📘 www.liebertpub.com/doi/10.1177/...
New study in Cannabis and Cannabinoid Research shows that:
➡️ PEG is a more effective carrier oil for vaporized cannabis than PG/VG
➡️Adolescent mice are less sensitive to cannabis-induced motor slowing
➡️Female mice metabolize THC more slowly than males
📖 doi.org/10.1177/2578...
🌿 During COVID-19, 91% of adults with chronic conditions reported using cannabis to self-manage symptoms like sleep, pain, headaches, and nausea—even without a medical recommendation.
🔗 doi.org/10.1089/can....
#CannabisResearch #ChronicHealth #COVID19 #SelfCare
🔥 New study: Nearly 1 in 3 Californians aged 50+ is a caregiver, & caregivers—especially those supporting someone with dementia—are more likely to use cannabis than non-caregivers. Call for more work on whether cannabis helps or harms caregiver well-being: doi.org/10.1177/2578...