Are you obsessed with #DendriticCells? Curious? Running into them in your experiments?
Then ✳️ #DC2026 is your meeting!
Registration & abstracts are OPEN.
Top-tier speakers and more to come.
⭐️ Come for the science. Stay for the community. @maxkrummel.bsky.social @zunigalab.bsky.social
Sirimuvva Tadepalli, Derek Clements, Juliana Idoyaga @idoyagalab.bsky.social and colleagues reveal that CD301b⁺ monocyte-derived dendritic cells mediate resistance to #radiotherapy 👉 rupress.org/jem/article/...
📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025
A fascinating education in #LangerhansCell biology and function from Clare Bennett, as well as a closing advert for the 18th International #DendriticCell symposium in San Diego next year #EMDS2025 #DC2026
Tadepalli, Clements et al. @idoyagalab.bsky.social reveal that CD301b⁺ monocyte-derived dendritic cells mediate resistance to #radiotherapy. rupress.org/jem/article/...
📘 #Macrophages and #DendriticCells in Health and Disease 👉 rupress.org/jem/collecti...
Thanks Judith!
Thank you so much Hiu!! 🙏
Thanks 🙏 Michael!!
Gracias Miguel! 🙏
Thank you Maria!!
Thank you Caetano! 🙏
Thanks Amy!! 🙏
Our paper made the cover of Nature Immunology’s September issue! 🎉
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
Thanks to @idoyagalab.bsky.social for supporting my postdoctoral work and making this paper possible. Super excited to show how pDCs regulate their antigen presentation function switching to cDC2!
Delighted to share that our @natimmunol.nature.com paper has now a fantastic News & Views
🔗 www.nature.com/articles/s41...
Thank you, @esegura-lab.bsky.social, for a clear and thoughtful summary 🙏
And thanks to our 3 amazing reviewers: your feedback made this work stronger. Peer review at its best!
Why it matters:
This pDC → cDC plasticity could let us tune immunity — boosting antiviral defenses or damping harmful inflammation in autoimmunity.
A new lever for immune therapy?
This isn’t just in a petri dish:
We saw it in human skin inflammation, wounds, and even healthy aging.
pDC plasticity happens in vivo — actively shaping immune responses in health & disease.
Using single-cell omics + functional assays, we saw activated pDCs lose IFN-I machinery & gain cDC type 2 (cDC2) traits— a full fate switch.
Two key regulators:
TNF → is the switch push
IFN-I → is the restrain
pDCs are famous for cranking out type I interferon to fight viruses.
Conventional DCs (cDCs) present antigens to activate T cells.
But here’s the puzzle: why are pDCs part of the dendritic cell family at all? 🤔
Turns out, they can change teams.
🚨 Our latest paper is out in @natimmunol.nature.com ! 🧵
Plasmacytoid dendritic cells (pDCs) — the immune system’s IFN-I powerhouses — can change their identity!
Congrats to @rebecaarroyo.bsky.social, our team & collaborators 👏👏
🔗 www.nature.com/articles/s41...
Langerhans Cells, Dendritic Cell and #skinimmunology lovers❤️ #LC2025 registration is NOW OPEN! Meet us in St. Louis @washu_pathology, Sep. 3-5, 2025, Amazing program! Intimate and collaborative discussions on breakthrough discoveries! register today at langerhans.org
Our latest @jem.org paper is out!
Radiotherapy induces GM-CSF in melanoma, driving monocytes to become regulatory monocyte-derived dendritic cells (moDCs)—traced with Ms4a3-TdTomato mice!
Huge shoutout to @Sirimuvva Tadepalli + @Derek Clements for leading this!
✋🙏! Thanks!
We are ramping up our attempts to get DC1 immunotherapy into the clinic for colorectal and lung cancer. Here me talk about why DC1s are the right choice, and how
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...
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