Muller glia (green) regulate local retinoic acid signalling to specialise photoreceptor outer segments (magenta)for high acuity visual function
Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. www.biorxiv.org/content/10.6.... We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity visual function.
Exciting announcement! My new department is launching a postdoc fellowship in quantitative biology. Fellows will be co-advised by two Bio faculty, one that is quant focused (not me) and one that is not (me???). I would love to co-sponsor a postdoc and build a collaboration so please reach out!
And the other half of setup: pollo en salsa verde
The setup for vegetarian tamales tomorrow: salsa roja, nopales y champiñones con comino.
I am very excited to share the first Accorsi lab publication: a collection of detailed protocols to maintain an apple snail 🐌 colony and generate stable mutant lines. The video is coming soon @ JoVE! We hope this will be a valuable resource for the community. app.jove.com/t/69267/the-...
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
Still looks yummy.
We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.
Right? It’s just awesome to be able to interact with the data.
you should all check out @john-m-ball.bsky.social latest paper (www.pnas.org/doi/10.1073/...) : in the Zenodo files there is an interactive pdf that let's anyone look at the 3D EM reconstructions.
For CHSL conferences too!
“Much” is a relative term… can’t trust it
An array of 9 purple discs on a blue background. Figure from Hinnerk Schulz-Hildebrandt.
A nice shift in perceived colour between central and peripheral vision. The fixated disc looks purple while the others look blue.
The effect presumably comes from the absence of S-cones in the fovea.
From Hinnerk Schulz-Hildebrandt:
arxiv.org/pdf/2509.115...
Our new tool for automating the quantification of synapses (or any other fluorescent puncta) in C. elegans is published- please try it out!! journals.plos.org/ploscompbiol...
We did fluorescence microscopy : dark contrast, DAPI, YFP, mCherry, tdTomato, miRFP, DIC and bright field
@ninaluong.bsky.social is really upping her costume game this year. And she can still work in it!
Lots of very serious people are working on how to share big datasets across archives and rigging up all sorts of cloud proxy systems and bridges and whatnot and I am here to tell you that torrents with multiple webseeds have already solved that problem
@fim.bsky.social: recommendation on mail-in service for developing film rolls? Found my dad’s old camera and took it for a spin.
Got mine! Gave them to grad students to put in wise places
Could @marimo.io and @processing.org work together? Always wanted to dynamically alter stuff on the processing canvas and I love the UI and widgets of marimo. Tutorial possible?
I saw this in Woods Hole! A deer in the sea 🤯. Got to shore. Took off.
Some zebrafish line eye dancing at @mblscience.bsky.social Visual Neuro course. Teaching OKR how John Dowling and Jim Fadool taught me during the zebrafish course.
Should have taken more pictures. Blame it on the lack of sleep. But here is @gregschwartznu.bsky.social giving a lecture on retinal ganglion cells after @richkramerlab.bsky.social talked about the rod pathway. @mblscience.bsky.social Visual Neuro course.
And today: Dave Zenisek and more ribbons!
@mblscience.bsky.social Visual Neuro course
John Dowling showing students (and faculty) some ribbon synapses.
STED images showing localization of Intersectin 1 and Synapsin 1 relative to the active zone, marked by Bassoon
Super excited to share that our new study is published @natneuro.nature.com today!! Here we show that intersectin and endophilin form condensates between the active zone and the reserve pool and maintain synaptic vesicles near the active zone for rapid replenishment.
rdcu.be/evi5y
Picture of eel pond
Picture of old books in the MBL/WHOI library stacks.
Working on lecture for the @mblscience.bsky.social neuro course at the library. Front view vs. back view?
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