MitoMavericks

Rare Disease Day – 28 February 2026
Let’s unite to improve diagnosis and understanding of mitochondrial disease.

These rare conditions can affect any organ, at any age, impacting at least 1 in 4,000 people. Greater awareness and research are vital.

#RareDiseaseDay #MitochondrialDisease

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...

A wonderful collection of literature from #week8 on #Mitochondria in #Health & #Disease! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A [...] bifunctional enzyme mitigates redox imbalance and lipotoxicity
www.nature.com/articles/s42...

The next big thing in wellness is…mitochondria? People are suddenly very concerned about the powerhouse of the cell.

The next big thing in wellness is mitochondrial health.
www.vox.com/advice/47803...

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

A new collection of papers on #Mitochondria in #Health and #Disease! #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mt superoxide regulates nuclear integrity and ageing via lipid metab

www.nature.com/articles/s42...

Mitochondria painting - without the pain(t). Unvarnished mitochondrial biology, live, and at scale.

A new collection of papers from #week5 on Mitochondria in Health & Disease! #MitochondrialDisease
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Among highlights
www.nature.com/articles/s41...

https://academic.oup.com/nar/article/54/2/gkag008/8433879?login=false

A new collection of papers on Mitochondria in Health and Disease! #week3 #MitochondrialDisorders
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Human mitochondrial helicase Twinkle has RNA binding, annealing, and strand-exchange activities

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...

Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

www.nature.com/articles/s42...

I asked AI to describe my contribution to the mitochondrial field. Received this. It's quite impressive and pretty accurate.

Excited to speak at the symposium “Artificial Intelligence in Mitochondrial Medicine”

🧬 Exploring how AI is transforming mitochondrial medicine
📍 Pisa, Italy | 🏨 Hotel Galilei
📅 Jan 23, 2026

#AIinMedicine #MitochondrialMedicine #DigitalHealth #PrecisionMedicine

Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...

Last 2 weeks of research papers relevant to #MitochondrialDisease!
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...

Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

Reviews/Perspectives Top #Citations 2025: 🥇🧪

Jonathan Brestoff (Washington U Dept Med), Keshav Singh (@mitoscientist.bsky.social, U Alabama) et al.

Recommendations for mitochondria transfer and transplantation nomenclature and characterization

Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

Reviews/Perspectives Top #Altmetric 2025: 🥇🧪

Jonathan Brestoff (Washington U Dept Med), Keshav Singh (@mitoscientist.bsky.social, U Alabama) et al.

Recommendations for mitochondria transfer and transplantation nomenclature and characterization

🌹🌹May all that is beautiful and meaningful and brings you and your family joy be yours throughout the coming year! Wish you a very happy new year!🌹🌹

End-of-year selection of papers on #MitochondrialDisease! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mitoscientists.bsky.social
Have a great 2026! ✨

Mitochondria are among nature's most remarkable gifts to us. These tiny powerhouses are essential for providing
energy and stand at the forefront of anti-aging science, serving as the driving
force behind strategies to promote healthy longevity.

🍃 🏛️ ✏️ 🧪 Forgotten NIH Required Attachments for Applications
Dec 22, 2025

Death By a Thousand Cuts Capstone Archive Submission YouTube video by Usha Sookai

Powerful short documentary about the researchers affected by NIH grant terminations and broad extortion of universities.

youtu.be/DaTOmUZHeik

1/2

A woman scientist is reading books in the library.

Christmas edition🎄of #MitochondrialDisease collection of papers! 🎁 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Fuel your mitos well and happy holidays!

It's an honor to see Yuva Biosciences and our contributions in the field featured in this mitochondrial story in The Washington Post today.

https://www.cell.com/cms/10.1016/j.cell.2025.11.002/asset/6a29b9bb-e6a4-4eb7-a86a-b1f1f5fd697f/main.assets/fx1_lrg.jpg

Such a great collection of papers on #mitochondrialdisease from #week49! 📚 Congratulations to all authors! biomed.news/bims-mitdis/...
@biomednews.bsky.social @mitoscientist.bsky.social

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al

https://www.cell.com/cell/abstract/S0092-8674(25)01242-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425012425%3Fshowall%3Dtrue

#mitochondrialdisease collection of papers from #week48! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Inhibition of oligomeric BAX by an anti-apoptotic dimer
Newman et al

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social

Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...

A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...

Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...

Great collections of papers on #mitochondrialdisease from #week42 and #week43! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...

Happy Diwali-The Festival of Lights
As we celebrate this beautiful festival that
symbolizes the triumph of light over darkness, knowledge over ignorance, and good over evil - let us rekindle the light within us to create a brighter future for all.

#Diwali #diwalicelebration #deepavali

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...