Chris Deppmann

Extrinsic Apoptosis and Necroptosis in Telencephalic Development: A Single-Cell Mass Cytometry Study Regulated cell death is integral to sculpting the developing brain, yet the relative contributions of extrinsic apoptosis and necroptosis remain unclear. Here, we leverage single-cell mass cytometry (...

Hot off the press from my lab & @zunderlab: extrinsic apoptosis & necroptosis play tag-team in brain dev! Jiachen Shi crushed it with single-cell mass cytometry.
www.biorxiv.org/content/10.1...

Characterizing Microglial Signaling Dynamics During Inflammation Using Single‐Cell Mass Cytometry Microglia play a critical role in maintaining central nervous system (CNS) homeostasis and display remarkable plasticity in their response to inflammatory stimuli. However, the specific signaling pro....

Congrats to Sushanth Kumar on his first corresponding author paper in Glia! 🎉👏

Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections.

doi.org/10.1002/glia...

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

Huge congrats to Lizzy et al for showing how next-gen GLP1R drugs hack your amygdala to make your dopamine neurons say 'nah' to that second slice! 🧠🍰❌
Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1

A single-cell mass cytometry-based atlas of the developing mouse brain Nature Neuroscience - In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a...

Exciting news from our lab! Amy, Eli, and the team just published a single-cell mass cytometry atlas of the developing mouse brain! 🧠 24M cells profiled, 85 unique clusters identified—shedding light on protein-level cell state dynamics. Congrats, team! rdcu.be/d30MN

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...

We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.

Threads will follow!

@deppmann.bsky.social 🤷‍♂️