Julia Eberhard

Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits - Nature Neuroscience Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits, suggesting new t...

Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits

www.nature.com/articles/s41...

De-coupling immune parameters and toxicity associated with IL-12 agonism Lanzar et al. use a combination of half-life extension and IL-12 variants to explore the toxic effects of IL-12 treatment. These datasets highlight the cellular pool of innate and adaptive lymphocytes...

Ha - big week for IL-12... De-coupling immune parameters and toxicity associated with IL-12 agonism: Cell Reports www.cell.com/cell-reports...

Thanks Caroline!

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii - Nature Microbiology In vivo and in silico analyses suggest that bradyzoite-directed immunity contributes to control of cyst numbers, tissue damage and mortality in mice.

OUT NOW: Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii

@jueberhard.bsky.social @kingofpathogens.bsky.social

#microsky 🧪

www.nature.com/articles/s41...

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii Nature Microbiology - In vivo and in silico analyses suggest that bradyzoite-directed immunity contributes to control of cyst numbers, tissue damage and mortality in mice.

For those still interested in infection and the brain - here is a nice mix of math and pathogens - that tests the function of latency and how the immune system deals with a neuronal infection. Lots going on here to dissect - but turns out latency benefits host and parasite.
rdcu.be/efknc

Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii - Nature Microbiology In vivo and in silico analyses suggest that bradyzoite-directed immunity contributes to control of cyst numbers, tissue damage and mortality in mice.

Happy to share that our paper on immune targeting of T. gondii cysts and the role of this stage in persistence is finally out in @naturemicrobiol.bsky.social - Thanks again to all co-authors who made this possible!

www.nature.com/articles/s41...

The latent stage of Toxoplasma gondii is targeted by the immune response and host protective https://www.biorxiv.org/content/10.1101/2024.03.05.583527v1 Latency is a microbial strategy for persistence. For Toxoplasma gondii the ability of the bradyzoite

The latent stage of Toxoplasma gondii is targeted by the immune response and host protective https://www.biorxiv.org/content/10.1101/2024.03.05.583527v1

Chronic Toxoplasma gondii infection curtails the cytotoxic potential of acute T cell responses to West Nile virus in the brain. https://www.biorxiv.org/content/10.1101/2024.01.21.576564v1 Toxoplasma gondii (T. gondii), a common brain-tropic parasite, chronically infects the central nervo

Chronic Toxoplasma gondii infection curtails the cytotoxic potential of acute T cell responses to West Nile virus in the brain. https://www.biorxiv.org/content/10.1101/2024.01.21.576564v1

Experimenting with some cursed brain candy canes 🧠🍭