Hyung Jin Choi

Excited to share our new review on the cause and treatment of obesity based on personalized classification.
www.jomes.org/journal/view...

Wonderful! We have been following this since your biorxiv. I love your applications on "nudge" behavior and "settling point". Congratulations and thank you for insightful discussions.

Congratulations!! I always loved your work. I'm confident that you'll provide innovative findings! Excited!

Our recent review on the neural mechanism of GLP-1 drug. Focusing on the role of hypothalamus and cognitive function.
e-dmj.org/journal/view...

Very interesting data! Early Ensure neurons = orosensory food stimuli, Late Ensure neurons = food stimuli after swallowing. I'm also interested in the 1s pre-lick activity (smell, etc.?) I love these approaches to dissect these different phases of eating. Congratulations and thank you!

Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles - Experimental & Molecular Medicine The lateral hypothalamus (LH) is a key brain area involved in behaviors such as eating and drinking. This Review assesses how the LH controls eating, focusing on its complex organization. Researchers ...

I'm excited to share our recent review on lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.
www.nature.com/articles/s12...

Awesome! This review provides a timely overview of the complexity of NTS. Molecular x Spatial Models. DBH+ neurons in the rostral NTS have been shown to be orexigenic [44, 47], while their caudal counterparts are anorexigenic [44]!!! Intersting!

Let's meet at Keystone. Neurobiology of Ingestive Behavior. I will present "Neural Circuits Integrating Hunger and Food Choices" study.
www.keystonesymposia.org/conferences/...

Let's meet tomorrow at Cell Symposia: Neurometabolism in health and disease. I will present
"Accumbal Neuropeptide Y Neurons Promote Reward Learning through Value Updating for Palatable Food" study!!
cell-symposia.com/neurometabol...

My pleasure! Keep in touch

Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior Maladaptive feeding behavior is the primary cause of modern obesity. While the causal influence of the lateral hypothalamic area (LHA) on eating behav…

Excited to share our paper on Neuron. Chemogenetic activation of LH neurons in monkeys increased food motivation and naturalistic eating behaviors, mainly for palatable food. It's a translational follow-up of our rodent LH paper.
www.sciencedirect.com/science/arti...

A unified theoretical framework underlying the regulation of motivated behavior This article suggests psychophysiological components to regulate behavior. (1) “need”, an alarm regarding predicted deficiency. (2) “motivation”, a driver initiates behavior. (3) “pleasure”, a lesson...

What are the psychological components that regulate our behavior? We published a "PROBLEMS & PARADIGMS" paper proposing a theoretical framework. Our lab is conducting experiments to discover the neural substrates for each component. I hope you enjoy it!
onlinelibrary.wiley.com/doi/10.1002/...

A normative framework dissociates need and motivation in hypothalamic neurons Experimental and computational methods elucidate the neural substrates of need and motivation in hypothalamic neurons.

HAPPY to share our new paper! Are there specific neurons for food need (hunger) and food motivation (appetite)? Computational modeling and neural activity recording dissociated these two neurons.
www.science.org/doi/10.1126/...

GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients w...

Excite to share our paper on Science. GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans
www.science.org/doi/10.1126/...

Selected publications. Hyung Jin Choi GLP-1 Increases Pre-ingestive Satiation via Hypothalamic Circuits in Mice and Humans. Science. 2024 Hypothalamic Neuronal Activation in Non-human Primates Drives Naturalistic Goal-directed Eating Beh...

My research focuses on neural of eating and obesity with mouse, monkey and human.
Selected publications in Science, Neuron, Nature Communications, Science Advances and BioEssays: shorturl.at/DcUnm
CV: shorturl.at/UocTL
Lab Homepage: sites.google.com/snu.ac.kr/fn...
Google Scholar: shorturl.at/0scrl