Tycho Mevissen

Proteome-wide in silico screening for human protein-protein interactions Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

Graphical abstract for one of the papers

Graphical abstract for one of the papers

Graphical abstract for one of the papers

STK19
Transcription coupled repair
With TFIIH

#ChromatinHaiku
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
www.cell.com/molecular-ce...

Thank you, Ben!

Also check out related studies on STK19 by the labs of Martijn Luijsterburg/Jesper Svejstrup, Jurgen Marteijn/Titia Sixma, and Jinchuan Hu, respectively:

➡️ cell.com/cell/fulltex...
➡️ cell.com/molecular-ce...
➡️ academic.oup.com/nar/advance-...

STK19 positions TFIIH for cell-free transcription-coupled DNA repair Together with structural analyses, a cell-free system for transcription-coupled nucleotide excision repair (TC-NER) shows that STK19 is an integral component of the TC-NER complex that couples RNA pol...

Let's get this site started. I'm excited to share that our work on transcription-coupled DNA repair is now published! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples lesion-stalled RNA Pol II to TFIIH. 🧬🐸

➡️ cell.com/cell/fulltex...