Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...
Congrats Yunlu!! 🥳🥳🎉🎉
New preprint from Xhoela Bame et al shows that dying oligodendrocytes stick around for weeks to months without mitochondria! This happens after single cell DNA damage or when mitochondrial Fis1 is deleted in oligodendrocytes.
www.biorxiv.org/content/10.6...
Super excited to share this new paper led by @sejpaton.bsky.social that I briefly mentioned at #ACNP2026 yesterday! 🧪🧠🤓
We tested preventive strategies to protect the brain vasculature #BBB during stress exposure, mix of mouse 🐭 and human data
So proud of my team 🤘
www.nature.com/articles/s41...
🚨 PI position in dept. of Neuroscience with lab located the @crchum.bsky.social
Hiring at assistant/associate prof level in the fields of neural regeneration, stem cells and spinal-associated pathologies
can-acn.org/professor-re...
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles.
onlinelibrary.wiley.com/doi/10.1002/...
“Basic neuroscience hasn’t produced new drugs.” 💊
Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.
I wrote a Perspective on why this matters. @thetransmitter.bsky.social
www.thetransmitter.org/drug-develop...
Alicia Pietramale et al. discovered a disconnection between microglial processes that surveil or respond to acute damage and those that contain mitochondria. Cytoskeletal components and metabolic enzymes underlie these differences. Final version just published!
www.nature.com/articles/s41...
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
Yay!!!! Huge congrats Rafa!!! 🎉🎉🎉🎉
A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Flyer for a social for Glial Interactions at SfN. Monday Nov 17, 9PM-close, The Smoking Gun, 555 Market St. Microscopy images of two astrocytes (top, red/blue) and an oligodendrocyte and myelin sheaths (bottom, white/red).
If you’re interested in the roles of glia in stroke and TBI, kick off #SfN2025 with a minisymposium on Saturday afternoon in room 6B!
@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!
Party tiiiiime 🍺🍻🍾🥂🕺💃🪩
The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out!
www.raajgowrishankarlab.org
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
Audiobook cover of How to Change a Memory: One Neuroscientist’s Quest to Alter the Past by Steve Ramirez, read by the author
In How to Change a Memory, neuroscientist @okaysteve.bsky.social shares his disarmingly personal account of the new science of memory manipulation.
🎧️📔 The #audiobook, read by the author himself, is out now!
Add it to your #audio library: press.princeton.edu/books/audio/...
Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
Important article from @marymunson4.bsky.social @joann-trejo.bsky.social @needhibhalla.bsky.social
Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...
Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)
www.sciencedirect.com/science/arti...
A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.
If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!
Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.
All welcome, please free to spread the word!
Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
Fluorescently labeled astrocytes at varying distances from cortical or white matter stroke infarct border
Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair!
(see also - gorgeous astrocytes for fluorescence Friday)
www.sciencedirect.com/science/arti...
Come join us at @westernu.ca: Chair, Department of Medical Biophysics: www.uwo.ca/facultyrelat...
