Lauren Albrecht

PFKM governs metabolic shifts throughout skeletal muscle differentiation - Nature Metabolism Subcellular compartmentalization of the glycolytic enzyme PFKM regulates cell fate and metabolic switch during skeletal muscle differentiation.

Excited to share our latest work out today in @naturemetabolism.bsky.social @ucirvine.bsky.social www.nature.com/articles/s42...

Fantastic work!

Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its tiss...

Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth
Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon
bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...

pharmsci.uci.edu/2025/06/05/a...

The guinea pig serves as an alternative model to study human preimplantation development - Nature Cell Biology Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.

🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

Lipidome, proteome, LSD. What’s not to love??

Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....

So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd

Thank you Brian !!

Honored to be a 2025 Sloan Research Fellow! #sloanfellow

Pondering a purge of pesky pathological proteins?

The role of ionic blockades in controlling the efficiency of energy recovery in forward bias bipolar membranes - Nature Energy Bipolar membranes are increasingly being applied in a variety of electrochemical devices, yet understanding of how they operate in complex electrolyte environments is still limited. Here the authors o...

Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF

www.nature.com/articles/s41...

Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC 💊 @danafarber.bsky.social

CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint!

www.biorxiv.org/content/bior...

Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction Peroxisomes carry out a diverse set of metabolic functions, including oxidation of very long-chained fatty acids, degradation of D-amino acids and hydrogen peroxide, and bile acid production. Many of ...

Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction www.biorxiv.org/content/10.1...

"An early-life microbiota metabolite [peroxisome proliferator-activated receptor γ, or PPAR-γ] protects against obesity by regulating intestinal lipid metabolism [in mice]"
www.sciencedirect.com/science/arti...

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins - Nature Chemical Biology Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins in lysosomes.

... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...

Image shows a confocal microscopy image of methylated proteins in gold in HeLa cells organizing into cytosolic puncta with a nuclear costain shown in blue.

Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover.
www.nature.com/nchembio/vol...

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...

PROTAC protein degraders to drug the undruggable enter phase 3 trials Pharmaceutical companies are investing in therapies that target proteins for degradation, with trials ongoing for cancer, autoimmune diseases and neurological disorders.

www.nature.com/articles/d41...

Loving #CellBio2024 and excited to present in micro session MONDAY 10:30 AM 28C microsession #MrTAC #lysosome #degrader #TPD #methylation

Excited to attend ASCB #CellBio2024! The Albrecht lab will present on lysosomes, quality control, lipid / carbohydrate metabolism, and MrTAC TPD targeted degrader.
Please check out our lab's talks and posters:

mRNA compartmentalization via multimodule DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine Intracellular DNA assembly for mRNA vaccine compartmentalization facilitates antigen expression and enhances adjuvant efficacy.

A new #ScienceAdvances study demonstrates a vaccine for cancer immunotherapy that would speed up the efficiency of messenger RNA translation in cytoplasm—and effectively inhibited tumor growth. scim.ag/49qY0sY

Dream come true to be featured on the cover!

Happy to see you here so that I can know all the best people I should be following by just looking at whatever you have posted!! Doing all the hard work for me!!

Thank you @haoyin.bsky.social !!

Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨