Francis Lynn πŸ‡¨πŸ‡¦'s Avatar

Francis Lynn πŸ‡¨πŸ‡¦

@nictitate

dad, lab head, brewer, baker, beta cell maker https://lynnlab.com

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08.09.2023
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Latest posts by Francis Lynn πŸ‡¨πŸ‡¦ @nictitate

1. This is great
2. Take your antihistamines, Vancouver locals

09.03.2026 17:03 πŸ‘ 42 πŸ” 16 πŸ’¬ 2 πŸ“Œ 0

so 75% of info comes from an echo chamber. got it.

09.03.2026 22:52 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Β© CBC/Radio-Canada 2026. All rights reserved.

Great to talk with Matt Galloway on CBC The Current this morning about successful gene therapy for a human immune defect.

The Current with Matt Galloway - March 9, 2026: How a gene edit gave a B.C teen his life back.

www.cbc.ca/listen/live-...

@mattgalloway.bsky.social @bcchresearch.bsky.social

09.03.2026 18:58 πŸ‘ 7 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

Iran's government is more hardline, its people are poorer and more isolated, the region's on fire, and the global economy feels like its about to go into shock

If you want to know why people wanted to avoid war with Iran for so long, you're finding out in real time

09.03.2026 02:24 πŸ‘ 5088 πŸ” 985 πŸ’¬ 79 πŸ“Œ 30
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U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office A Science analysis reveals how many were fired, retired, or quit across 14 agencies

The U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office.

A Science analysis reveals how many were fired, retired, or quit across 14 agencies. Read more: https://scim.ag/4boPkq8

28.01.2026 17:31 πŸ‘ 470 πŸ” 328 πŸ’¬ 15 πŸ“Œ 34

Stable genius

09.03.2026 01:51 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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hands down the absolute *strangest* β€œon background” sourcing I have ever seen in the NYT. Completely bonkers stuff www.nytimes.com/live/2026/03...

07.03.2026 01:34 πŸ‘ 569 πŸ” 123 πŸ’¬ 30 πŸ“Œ 40
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

07.03.2026 01:59 πŸ‘ 680 πŸ” 416 πŸ’¬ 19 πŸ“Œ 61
Kanwal Sibal @KanwalSibal β€’ 6h
X
The Iranian ship will not be where it was if we had not invited it to talk part in our Milan exercise.
We were the hosts.
I am told that as per protocol for this exercise ships cannot carry any ammunition. It was defenceless.
The Iranian naval personnel had paraded before our president.
The attack by the US submarine was
premeditated as the US was aware of the Iranian ship's presence in the exercise to which the US navy was invited but withdrew from participation at the last minute, presumably with this operation in mind.
The US has ignored India's sensitivities as the ship was in these waters because of India's invitation.
We are far from politically or militarily responsible for the US attack.
Our"responsibility" is at a moral and human plane.
A word of condolence by the Indian Navy ( after political clearance) at the loss of lives of those who were our invitees and saluted our president would be in order.

Kanwal Sibal @KanwalSibal β€’ 6h X The Iranian ship will not be where it was if we had not invited it to talk part in our Milan exercise. We were the hosts. I am told that as per protocol for this exercise ships cannot carry any ammunition. It was defenceless. The Iranian naval personnel had paraded before our president. The attack by the US submarine was premeditated as the US was aware of the Iranian ship's presence in the exercise to which the US navy was invited but withdrew from participation at the last minute, presumably with this operation in mind. The US has ignored India's sensitivities as the ship was in these waters because of India's invitation. We are far from politically or militarily responsible for the US attack. Our"responsibility" is at a moral and human plane. A word of condolence by the Indian Navy ( after political clearance) at the loss of lives of those who were our invitees and saluted our president would be in order.

Some context to the Iranian boat that was targeted by US off Sri Lanka coast

Former Indian FM: β€œUS was aware of the Iranian ship's presence in the exercise to which the US navy was invited but withdrew from participation at the last minute”

05.03.2026 13:13 πŸ‘ 793 πŸ” 458 πŸ’¬ 66 πŸ“Œ 103
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Google pledges roughly three hours of its annual profit to fight climate change Google and others are committing $100 million to combat climate change.

The perfect headline doesn’t exi…

05.03.2026 20:24 πŸ‘ 7533 πŸ” 2183 πŸ’¬ 30 πŸ“Œ 65
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FT comments section this morning - saying what everyone else is thinking, right?

05.03.2026 07:15 πŸ‘ 17166 πŸ” 5983 πŸ’¬ 514 πŸ“Œ 492
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The Liberals have muzzled the federal fiscal watchdog After 18 years, the Parliamentary Budget Officer is without a voice, until the government gets around to naming a permanent successor
05.03.2026 11:49 πŸ‘ 6 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
jodilee539.bsky.social

latest preprint just dropped! From a fantastic collaboration between our lab and Katie Pollard's @gladstoneinst.bsky.social. @ucsanfrancisco.bsky.social graduate student Jodi Lee jodilee539.bsky.social and Gladstone postdoc Jingshing Wu led the project www.biorxiv.org/content/10.6... 1/x

04.03.2026 00:46 πŸ‘ 20 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

gonna walk up to ken sim and wave a fake ai generated photo of elias pettersson holding up the stanley cup so he can tell everyone the canucks are champions

04.03.2026 00:32 πŸ‘ 85 πŸ” 11 πŸ’¬ 1 πŸ“Œ 0
The figure shows gene expression analysis of unsorted, CD49 sorted and CD19 sorted SCΞ²-cells using NanoString analysis.

The figure shows gene expression analysis of unsorted, CD49 sorted and CD19 sorted SCΞ²-cells using NanoString analysis.

Luo Ting Huang, Yaser Tahamtani, @nictitate.bsky.social & co explored the possibility of magnetic selection of insulin-expressing stem cell‑derived β‑cells using a CRISPR/Cas9 technology and transmembrane glycoprotein CD19 as a marker.

@bcchresearch.bsky.social

Read: doi.org/10.1242/dmm....

02.03.2026 12:11 πŸ‘ 3 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

It’s a nice trail and viewpoint, hope you had good weekend on Bowen

02.03.2026 03:50 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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(Axios) - Anthropic's Claude hit No. 1 in U.S. app downloads Saturday, overtaking ChatGPT, after the Pentagon blacklisted the company for refusing to loosen safeguards for military use of its AI model.

@axios.com
www.axios.com/2026/03/01/a...

01.03.2026 16:05 πŸ‘ 751 πŸ” 207 πŸ’¬ 29 πŸ“Œ 46

It's nice to know that the Canadian government can re-discover the value of higher education. Perhaps less nice to note that it perceives the value as that of a prop for a PM's visit to another country.

28.02.2026 15:16 πŸ‘ 10 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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Canada and India deepen education collaboration with new talent and innovation strategy Today, the Honourable Anita Anand, Minister of Foreign Affairs, celebrated the launch of the new Canada-India Talent and Innovation Strategy, including the signing of 13 new partnerships, during her v...

I am not entirely sure how we can have a joint talent strategy with India when we don't actually have a domestic talent strategy of our own.

28.02.2026 14:46 πŸ‘ 11 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

Biochem tricks are one thing... I've got mentors who were some of the earliest recombinant DNA psuhers but they remind me that there were never "good old days" just lots of logging counts and screening clones

Being fluent in your current assembly and expression system, now that takes time and years

28.02.2026 07:26 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Sigh, here we go again

28.02.2026 03:06 πŸ‘ 4 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

How about you apologize to Vancouver now

27.02.2026 22:10 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

So cool, congrats!

27.02.2026 16:57 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

This is an OUTSTANDING LIFE-CHANGING outcome, based on research and healthcare by @turveylab.bsky.social and colleagues @bcchresearch.bsky.social

Hooray for the family!
Hooray for Stuart T & the other clinicians and scientists!
β€οΈπŸŽ‰β€οΈπŸŽ‰β€οΈπŸŽ‰β€οΈ

27.02.2026 04:24 πŸ‘ 8 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Ever since I was a little girl, I knew that I wanted to answer 275 emails per day and argue with administrators. That’s why I chose a career in academia.

26.02.2026 17:01 πŸ‘ 165 πŸ” 32 πŸ’¬ 3 πŸ“Œ 2

Approximately 20 million vertebrate animals, moslty mice, are used in research each year. Some comparisons on agricultural use.

26.02.2026 17:52 πŸ‘ 26 πŸ” 15 πŸ’¬ 6 πŸ“Œ 0

🚨Don’t upload other peopleβ€˜s intellectual property to Ai. 🚨

26.02.2026 00:19 πŸ‘ 31 πŸ” 7 πŸ’¬ 0 πŸ“Œ 4

Something about doing the same thing over and over and expecting a different result seems relevant

25.02.2026 16:34 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Since this will likely come up in the SOTU: Yes, US stock markets are up since Trump took office (14%).
But in the rest of the world, markets are up WAY more. Cumulative market gains are more than triple ours (43%)

24.02.2026 23:04 πŸ‘ 2015 πŸ” 786 πŸ’¬ 57 πŸ“Œ 57