Marc A. Marti-Renom

Charting the 3D regulatory landscape of sex determination with geostatistics Nature Structural & Molecular Biology, Published online: 06 March 2026; doi:10.1038/s41594-026-01750-6METALoci, a computational framework to study the 3D genome, reveals a prominent rewiring of regulatory interactions during sex determination. This geostatistics-inspired method also uncovered a previously unknown non-coding regulatory region at the Fgf9 locus and identifies Meis genes as crucial regulators of sex differentiation.

ICYMI: New online: Charting the 3D regulatory landscape of sex determination with geostatistics

Do not think twice! 👇🏻👇🏻

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs - Nature Structural & Molecular Biology METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors ...

Tempted to add Metal gifs; that's how cool METALoci sounds!
In their recent article @natsmb.nature.com, @dariloops.bsky.social @mamartirenom.bsky.social @jrotwitguez.bsky.social @imotagom.bsky.social and colleagues shed light on sex-determining 3D regulatory hubs.
www.nature.com/articles/s41...

Last week, CNAG participated in the 2nd Genomic Regulatory Network Annual Meeting, funded by @ageinves.bsky.social and hosted by @cbm-csic-uam.bsky.social

A great opportunity to share the latest results & foster collaboration

With @mamartirenom.bsky.social, Structural Genomics Group Leader at CNAG

I Jornada de Biologia del Càncer 🎗️

La Secció de Biologia del Càncer de la SCB celebra la seva primera jornada, un espai dedicat a compartir i debatre els darrers avenços en recerca oncològica ⬇️

Work with us at CNAG! 👇🏻👏🏻

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 We’re happy to announce (finally!) the publication of METALoci, in collaboration with @dariloops.bsky.social and heroes: @jrotwitguez.bsky.social & @imotagom.bsky.social.

METALoci integrates #3DGenome and #Epigenetics data into a unified framework we believe is very useful!

Here 👉🏻 rdcu.be/e5sm2

Thanks Agnese! 😃

25 anys de la publicació de la seqüència del genoma humà 🧬

Aquest 2026 es compleixen 25 anys de la publicació de la seqüència del genoma humà, una fita científica que va marcar un abans i un després en la biologia i la medicina moderna⬇️

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 Happy to see that my PhD work is finally published!

We present METALoci, a tool that integrates #3Dgenome and #Epigenetics to identify regulatory hubs.

Applied to #sexdetermination we uncover:
✔️ Non-coding regulatory region controlling Fgf9
✔️ Meis genes as key players

👉 rdcu.be/e5sm2

La biodiversitat dels líquens als Països Catalans🌿

Continuem compartint els continguts del Volum 75 de la revista #Treballs de la Societat Catalana de Biologia, dedicat enguany a la biodiversitat 👇

And Juan also masters bluetorials 👇🏼👇🏼👇🏼😀

And Dario doing the magic of bluetorials! 👇🏼👇🏼👇🏼😀

Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

🚨 We’re happy to announce (finally!) the publication of METALoci, in collaboration with @dariloops.bsky.social and heroes: @jrotwitguez.bsky.social & @imotagom.bsky.social.

METALoci integrates #3DGenome and #Epigenetics data into a unified framework we believe is very useful!

Here 👉🏻 rdcu.be/e5sm2

🚀 New paper out in @natsmb.nature.com!
🔝Dr @mamartirenom.bsky.social (Structural Genomics Group Leader at CNAG and CRG) and Dr Juan Antonio Rodríguez launch 𝗠𝗘𝗧𝗔𝗟𝗼𝗰𝗶, a novel computational framework that reveals the 3D mechanisms of sex determination in mammals

📎 www.cnag.eu/news/metaloc...

Congrats Cees!!!

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Fa 25 anys de la publicació de la primera seqüència del genoma humà, un esforç internacional que va tenir aportació catalana, amb els investigadors Pep Abril @geneticsub.bsky.social i Roderic Guigó @crg.eu

Podeu consultar la notícia completa al 3cat:
www.3cat.cat/3cat/telenot...

La biodiversitat dels fongs i els seus problemes, avui, als Països Catalans i al món 🍄

Continuem compartint els continguts del Volum 75 de la revista Treballs de la Societat Catalana de Biologia, dedicat enguany a la biodiversitat⬇️

Interested in transcriptional regulation, enhancers and 3D genome folding?

In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control

www.biorxiv.org/content/10.6...

detailed 🧵👇

Karolin Luger - Vilcek Foundation Karolin Luger's research led to the capture of a high resolution image of chromatin, resulting in the development of innovative drug treatments for diseases like cancer.

Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt 🙏 to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...

What a Team! One can only expect excellent science from this ERC-Syn! 👇

Please share!
My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th!
uni-tuebingen.de/universitaet...

It has been two weeks since the unexpected death of Peer Bork, and all of us in his research group are deeply missing him. His scientific vision brought us together as a team, and we are immensely grateful for the time we spent together. 🧵

We are thrilled to announce Francis S. Collins, former director of the NIH, as the 2026 NAS Public Welfare Medalist for his pioneering research in human genetics and critical contributions to public welfare as the leader of the Human Genome Project! www.nasonline.org/news/francis... #NASaward

Head, Advanced Genomics Technologies Core Facility (Ref. CF/26/01) - IRB Barcelona IRB Barcelona invites applications for the position of Head, Advanced Genomics Technologies Core Facility. The successful candidate will report to the Director, Technology Strateg...

🚨WE'RE RECRUITING AT @irbbarcelona.org !!!!

--- ADVANCED GENOMICS FACILITY MANAGER ---

An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!!

APPLY NOW!!!!

recruitment.irbbarcelona.org/jobs/7124180...

👇👇👇👇

🚨 New preprint from the lab. Combining modeling and data analysis of SisterC data in yeast, we investigate cohesion of replicated chromosomes and show that sister chromatids are loosely and asymmetrically aligned in G2/M. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.6...

La biodiversitat de les algues dels Països Catalans 🌿

Continuem compartint els continguts del Volum 75 de la revista #Treballs, dedicat enguany a la biodiversitat⬇️

If you are interested in doing your research in Catalonia (highly recommended). This call is for you! 👇