@vdangioE3lab

Paused MRC funding calls to restart earlier than expected - Research Professional News Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure

Paused MRC funding calls to restart earlier than expected.

Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure.

www.researchprofessionalnews.com/rr-news-uk-r...

Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using genome-wide screening, we show ERCC6L2 is specifically required to maintain repair fidelity at staggered DNA breaks, but not at blunt ends.
www.nature.com/articles/s41...

UK university unions demand pay rise 3% above inflation - Research Professional News Employers describe claim as “extremely challenging” in current financial climate

UK university unions demand pay rise 3% above inflation

Employers describe claim as “extremely challenging” in current financial climate

www.researchprofessionalnews.com/rr-news-uk-u...

Elsevier rejections: libraries ‘had to make cuts somewhere’.

Experts say publisher’s pricing and profits are likely factors in rejection by some universities.

www.researchprofessionalnews.com/rr-news-uk-o...

Job losses at research-intensive universities double in two years - Research Professional News Exclusive: Scale of redundancies revealed by RPN branded a “disaster” for UK research capacity

Redundancies at research-intensive universities double in two years.

www.researchprofessionalnews.com/rr-news-uk-u...

Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna!
Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC).
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to stay in the loop: docs.google.com/forms/d/e/1F...

Job losses at research-intensive universities double in two years - Research Professional News Exclusive: Scale of redundancies revealed branded a “disaster” for UK research capacity

Job losses at UK research-intensive universities double in two years.

Exclusive: Scale of redundancies branded a “disaster”.

www.researchprofessionalnews.com/rr-news-uk-u...

Post-replicative chromatin accessibility predicts cell fate change Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

Blood test for 50 cancers fails key goal in NHS trial The company behind the test said there were positive signs that some of the most aggressive cancers could be prevented.

www.bbc.com/news/article... interesting

📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’

📅22-25 June 2026
📍CRUK Scotland Institute, Glasgow
🎟️Early Bird registration closes on 1 April
🔗 www.beatsonconference.org

#BICC2026 #CancerResearch #Immunology

🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ https://genesdev.cshlp.org/content/early/2025/12/08/gad.352916.125.abstract


#PROTAC #KRAS #cancer #cancertherapy

Yep

Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community!
We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.

Cara Maria Carmela Masi,
desidero ringraziarti per la menzione:
www.ecodicaserta.it/notizie/cult....
Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.

Three UK research councils suspend funding opportunities Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts

Three UK research councils suspend funding opportunities
“Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts”

Or:
Scientists are furious that they are learning of pauses to their main access to funding through press snippets rather than first hand dialogue with Uni research offices………..

Nature's Impact Factor is in the Epstein Files. Really.

That would be catastrophic

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

Dear Colleagues,

Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊

We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.

👉 rdcu.be/e1bBt

SS18::SSX activates Polycomb target genes without BAF ❌
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social

When science discourages correction: How publishers profit from mistakes Academic publishing system often allows scientific errors to persist because it prioritises profit and prestige over timely correction.

Academic publishing is now one of the most lucrative industries per unit of input

theconversation.com/when-science...

Am spending my Saturday reading grant proposals and feeling such pessimism about the state of uk science funding. So many good ideas, so many talented researchers, so incredibly little investment 😞

Two more Wellcome Discovery Awards reinforce Leeds as leader in biological research Some of Leeds’ top biological researchers have received two new Wellcome Discovery Awards, confirming the university’s status as a centre of excellence in biological research.

Leeds researchers have secured two major Wellcome Trust Discovery Awards.

The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.

🔗Full story: bit.ly/4oW3D99

@astburycentre.bsky.social @universityofleeds.bsky.social

Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com

I have a PhD position available with start date September 2026 at the University of Manchester.

Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes

Due to funding requirements, this position is for UK home students only.

www.findaphd.com/phds/project...

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...

Cara Maria Carmela Masi,
desidero ringraziarti per la menzione:
www.ecodicaserta.it/notizie/cult....
Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.

In 2025, we reviewed a new lab record number of 117 manuscripts.

If I was to charge 250 EUR per hour and would invest 2 h of work for every review this would make 58500 EUR @springernature.com @elsevierconnect.bsky.social @embopress.org & Co. owe me and my junior co-reviewers...

Happy Sunday!

Happening now! #MeetTheEditors #CellBio2025

Induced proximity-based therapeutic modalities - Nature Reviews Drug Discovery Induced proximity modalities encompass monovalent and bifunctional agents, such as molecular glues and proteolysis-targeting chimeras, that induce an interaction between biomolecules to functionally m...

Induced proximity-based therapeutic modalities
nature.com/articles/s41...
rdcu.be/eOfBH

This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more