Rachel 👩🏻‍🔬

Our new micropub is out, where we evolve yeast strains that are both scientifically interesting and practically useful! Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast doi.org/10.17912/mic...

The lab is looking to hire 2 new undergraduate researchers! You'll get to work on yeast experimental evolution & genomics. UW students only (and this link won't work for others, sorry). Work study students very welcome to apply! Pays the prevailing minimum wage. app.joinhandshake.com/emp/jobs/106...

Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.

Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...

Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...

Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...

Lab freezer defrost day

A Trailblazing Geneticist Reflects On Her Life And Work Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

Functional evidence for G6PD variant classification from mutational scanning G6PD deficiency is the most common enzyme deficiency worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. Identifying people at risk is challenging, since most are ...

It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...

The yEvo Mutation Browser: Enhancing student understanding of experimental evolution and genomics through interactive data visualization Experimental evolution is a powerful method for studying the relationship between genotype and phenotype by observing how populations genetically adapt to controlled selective pressures. In educationa...

Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...

Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!

Thanks for sharing!! 🩷

Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP - Nature Structural & Molecular Biology Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess v...

I’m thrilled to share my first big paper is live on @nature.com SMB! I poured my heart into this project while I was a tech, and I’m so happy it’s out in the world now.

Plus, how often does someone get to say they published with their two best friends? 🎉

www.nature.com/articles/s41...

I passed my PhD program qualifying exam today! I am now a PhD candidate 🎉🧬

The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net

NSF slashes prestigious PhD fellowship awards by half US National Science Foundation announces lowest number of Graduate Research Fellowship Programme recipients in 15 years.

www.nature.com/articles/d41...

Congratulations to Abby McGee and Val Browning on being awarded NSF Fellowships, and to Matt Chaw, Marazzano Colon, Bria Metzger, Rachel Powell, and Catherine Sniezek on receiving honorable mention!

I am feeling very proud and grateful to have been awarded an Honorable Mention for the 2025 NSF Graduate Research Fellowship Program!

While I didn’t receive the award itself, it is so validating to be recognized at a national level as a junior trainee. I am definitely celebrating this win 🌟

Multiplex, multimodal mapping of variant effects in secreted proteins Despite widespread advances in DNA sequencing, the functional consequences of most genetic variants remain poorly understood. Multiplexed Assays of Variant Effect (MAVEs) can measure the function of v...

Check out our updated preprint for MultiSTEP and coagulation Factor IX! This work highlights my most substantial contributions from my tech days in @dougfowler.bsky.social's lab 🧬 www.biorxiv.org/content/10.1...

Gene behind orange fur in cats found at last After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do

After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY

UW Genome Sciences Join the conversation

I made a starter pack of folks affiliated with UW Genome Sciences (past and present)

go.bsky.app/L8RAbiJ

It's fairly sparse for now, so please let me know if you'd like to be added!

Channeled my inner Ms. Frizzle today - spent the day doing 1:1 scientific writing & editing with high school students ✍🏻

Zymo DNA clean & concentrator 5 kit on a black bench top. Zymo branded swag included: lip balm, water bath tube floaty, magnetic timer, and bound composition notebook.

Thanks so much Zymo Research for the graduate student starter kit!! This isn’t sponsored - just super stoked about it 🙌🏻

Attending my conference ever today! 🧬 #pnwyc #pnwyc2024

Take a look at the website I created for our lab! 🌐

Maitreya Dunham Named Chair of the Department of Genome Sciences Starting July 1, 2024.

It's not every day that you get voted on by the UW Board of Regents and get a letter signed by the president and provost. Looks like I'm officially Chair! (effective July 1, which is why this article is from earlier this month) huddle.uwmedicine.org/maitreya-dun...

Two new students starting in the lab today! Welcome grad student Rachel and undergrad Elinor!

Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways Abstract. Caffeine is a natural compound that inhibits the major cellular signaling regulator TOR, leading to widespread effects including growth inhibitio

New @yevolab.bsky.social paper in G3 led by @reneegeck.bsky.social and featuring work from the classrooms of Tim Renz and Rebecca Brewer! Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways academic.oup.com/g3journal/ar...

I am thrilled to share that I will be joining @maitreya.bsky.social’s lab for my thesis work, starting in June! 🔬🧬

Robin Aguilar on LinkedIn: #pride #sciencecommunication #genomics #dei #transscientist #research Last week, I presented a seminar on my graduate school research and advocacy through the Caltech Center for Inclusion and Diversity (CCID). A huge thank you to…

Robin is such a delight to work with (and to be around, generally). If you’re looking for speakers that match their skillset and expertise, please pass along their info!

www.linkedin.com/posts/robinx...

Multiplex, multimodal mapping of variant effects in secreted proteins bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

I am beyond thrilled to share this preprint with Nicholas Popp from Doug Fowler’s lab. I can’t wait to see where MultiSTEP goes next! 🧬🔬

Take a look here! ⤵️
www.biorxiv.org/content/10.1...

#deepmutationalscan #dms #vampseq #factorix #factor9 #hemophiliab

It seems to be a great publication day for our cohort - congrats Zach Amador!

Take a look here ⤵️
doi.org/10.1038/s414...