Tamra Ogilvie

The 3 hardest things to learn as a scientist:
1. Trust the data.. especially when it’s not what you expected,
2. Trust the data.. allowing it to change your direction,
3. Trust the data.. but not too much: test with new data at every turn.

A #neuron nucleus once gave me a heart-shaped “I love you back” #FluorescenceFriday ❤️
5 μm later I’m still not over it.

Science isn’t cold—it’s a labor of love.

Post your fave “experiment loved me” story? 👇

#Microscopy #BrainLove
#ValentinesDay

Generating cerebellar organoids from pluripotent stem cells Summary: This Special Article provides a comprehensive overview of the methods, applications and considerations for the generation of cerebellar organoids.

Some friends and I wrote a review with @biologists.bsky.social !! Together with Esther Becker and Simone Mayer, we explore the state of the cerebellum organoid field and offer practical guidance on getting this model system started in your own lab. journals.biologists.com/dmm/article/...

In our house, hockey is always on, but I will watch curling and freestyle skiing too. 😀🏒🥅

Check out our new website and meet the team! www.texaschildrens.org/ogilvie-lab. Thanks to Ben Pakuts, Ivin Varghese and the entire communications team for putting this together! @bcmfromthelabs.bsky.social

Fantastic paper by Olivier Ayrault and team!

link.springer.com/article/10.1...

So nice to see you again! Have a safe trip home.

I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1

Happy Holidays!

Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues - Nature Cell Biology Yuan et al. present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments.

☕@drmingyaoli.bsky.social & co present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments.
bit.ly/4j2rIcG

Happy Holidays from this amazing team! 🎄🎅🤶

Excellent work by Dr. Jamie Zagozewski! Thank you to @neurodevkathy.bsky.social and @haldipur.bsky.social for contributing and to the editors at Dev Cell for the kind invite!

We highlight the unmet needs in the field pertaining to tumor modeling, molecular programs driving metastatic cells, and post-transcriptional regulation of cell fate.

Medulloblastoma stem cell programs: Molecular roadmaps of disease progression In this perspective, Zagozewski et al. summarize current knowledge about the primitive neurodevelopmental programs that drive medulloblastoma progression. The authors also highlight the unmet needs in...

Happy Thanksgiving! To cap off 2025, we are pleased to share our Perspective piece in @cp-devcell.bsky.social on medulloblastoma stem cell programs. www.cell.com/developmenta...

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism - Acta Neuropathologica Communications It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZ...

EZHIP has been puzzling us for years because of its incompletely understood role in pediatric brain tumors. Here we report new functions for EZHIP and that EZHIP is not only mutated in PFA ependymoma, but also in K27M+ HGGs with EGFR mutations.
actaneurocomms.biomedcentral.com/articles/10....

I know! VLADDY!

The game is very stressful! Go Jays!

Happy to welcome Dr. Xinmiao Yan, our new bioinformatician, to the Ogilvie lab! Thrilled to have her join our expanding team of medulloblastoma researchers!

Professor at the rank of Assistant or Associate Professor, in the field of neurocircuitry - Montréal, Quebec (CA) job with Université de Montréal | 12843808 Professor at the rank of Assistant or Associate Professor, in the field of neurocircuitry involved in the production of complex behaviors

🚨Another PI job opening in the Neuroscience dept. at @umontreal.ca ! 🚨

www.nature.com/naturecareer...

Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children.
These children need MORE funding and MORE trials, not less.
They deserve better

Developmental, Stem Cell & Cancer Biology | SickKids Research Institute The Developmental, Stem Cell & Cancer Biology program has led significant discoveries in developmental genetics, genomics, stem cell and cancer biology.

SickKids Research Institute has just launched a search for Program Head in Developmental, Stem Cell and Cancer Biology. Phenomenal colleagues, amazing science and great food all in the most multicultural city in the world. Join us: www.sickkids.ca/en/research/...

Thank you to the Sam Day Foundation for funding our work on medulloblastoma metastasis! We are very grateful for the support! 🙏🏻🎗️

Excited to speak at this event next week!

A year of stem cell and developmental biology In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...

☕Attending the @isscr.org meeting next week and looking for a recap of interesting work in the field during the past year? Take a look at our collection of #StemCell and development papers published across @natureportfolio.nature.com during the past 12 months!

www.nature.com/collections/...

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

Happy to welcome 2 new lab members! Lily and Baoqi are PhD students in the Cancer & Cell Biology Graduate Program, and we are thrilled that they have joined our medulloblastoma research team! @bcmfromthelabs.bsky.social

Locum Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences) Job title: Locum Associate or Senior Editor, Nature (Biological, Clinical, and Social Sciences) Location: New York or Berlin (Hybrid working pattern) Deadline: June 11th , 2025 About Springer Nature G...

We (the Nature Biology team) are looking for a locum edigtor to handle stem cell biology, developmental biology, and specific aspects of general cell biology, either in our Berlin or New York offices. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!