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SHIELD Lab

@bgauthierlab

Strategic Healing and Immuno-Endocrine Division led by BGauthier at @cabimer @FProgresoysalud. With @BreakthroughT1D, @diabetes_CERO, @ciberdem

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14.11.2024
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Latest posts by SHIELD Lab @bgauthierlab

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The lab’s official account is here! Welcome to
@bgauthierlab.bsky.social
(Strategic Healing and Immuno-Endocrine Division/SHIELD LAB). Follow us for updates on our latest research, publications, and news. Stay connected for exciting discoveries ahead 💯💪⬇️⬇️

21.01.2026 10:58 👍 0 🔁 0 💬 0 📌 0

Sintoniza
@losreporteroscs
.Con :
@AUGC_Comunica
,
@jucilnacional
,
@corazonbandera
,
@cabimer
,
@diabetes_CERO
,
@AndaluciaJunta
,
@saludand
,
@ICOESevilla
y
@HUVMacarena

08.02.2025 15:49 👍 1 🔁 0 💬 0 📌 0

No te pierdas esta noche en "Los Reporteros" un reportaje exclusivo para entender, conocer y ver cómo luchar contra la #DiabetesTipo1. Conduce la maravillosa periodista
@mabelmata1 y participa nuestro querido @sevillegauthier
quien hablará sobre su innovador trabajo en este campo.

08.02.2025 15:49 👍 1 🔁 1 💬 1 📌 0

Do not miss this excellent review on the roles of Bcl-2 & Bcl-xL beyond apoptosis, detailing their impact on β-cell survival, calcium homeostasis, mitochondrial function, and diabetes progression. It also discusses therapeutic strategies targeting these pathways. A must-read! 👏🔬

30.01.2025 04:17 👍 3 🔁 1 💬 1 📌 0
Preview
LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induce...

Excited to share our latest paper on LRH‐1/NR5A2: targeting mitochondrial dynamics to reprogram macrophages and dendritic cells in T1D into an immune-tolerant phenotype! Thanks to the amazing team&collaborators 🙌 #T1D #Mitochondria #NuclearReceptors #Immunometabolism
doi.org/10.1002/ctm2...

20.12.2024 18:05 👍 5 🔁 1 💬 0 📌 0
Preview
Investigadores evalúan el potencial antidiabético de moléculas de segunda generación - El grupo de científicos de la Fundación Progreso y Salud, liderado por Benoit Gauthier, ha recibido financiación de la Fundación DiabetesCERO para impulsar este proyecto

Thrilled to begin a new chapter with @diabetes_CERO! Their generous funding helps us secure the talent needed to develop 2nd-gen LRH-1/NR5A2 agonists for #T1D treatments. Thanks for your continued support in the fight against T1D!@cabimer @AndaluciaJunta @BreakthroughT1D lc.cx/xB2awa

28.01.2025 08:11 👍 3 🔁 0 💬 0 📌 0
Preview
LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induce...

Excited to share our latest paper on LRH‐1/NR5A2: targeting mitochondrial dynamics to reprogram macrophages and dendritic cells in T1D into an immune-tolerant phenotype! Thanks to the amazing team&collaborators 🙌 #T1D #Mitochondria #NuclearReceptors #Immunometabolism
doi.org/10.1002/ctm2...

20.12.2024 18:05 👍 5 🔁 1 💬 0 📌 0
Preview
LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induce...

🚨 New Research 🚨

Our latest study in Clin. Transl. Med. shows LRH-1/NR5A2 activation fosters immune tolerance in T1D by reducing inflammation, promoting tolerogenic dendritic cells, and expanding regulatory T-cells.

A step forward in T1D research. 🙌

dx.doi.org/10.1002/ctm2...

20.12.2024 10:43 👍 1 🔁 0 💬 0 📌 0
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We are recruiting a postdoctoral research associate! Have a look at the flyer and/or the links below and get in touch if you have any questions! And please, share widely!!
www.imperial.ac.uk/jobs/search-...

27.11.2024 17:50 👍 7 🔁 7 💬 0 📌 2

www.linkedin.com/posts/benoit...

16.11.2024 10:59 👍 0 🔁 0 💬 0 📌 0
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A review we published on the idea that #T1D and autoimmune diseases should be considered unresolved wound-healing and that the optimal treatment should reeducate, NOT suppress, the immune system to allow regeneration. Food for thought
www.metabolismjournal.com/article/S002...

14.11.2024 19:46 👍 0 🔁 0 💬 0 📌 0