Matt Allen

Excited that so many people came out to celebrate safety, and very proud of my lab!

Controlling the Kinetic and Electrochemical Properties of EuII–Containing Complexes Using Peripheral Charges The development of Eu-based contrast agents for magnetic resonance imaging requires careful balance between electrochemical potential and inertness with respect to metal dissociation. Using coordination chemistry, this study aimed to understand how the distance between peripheral anionic groups and EuII in macrocyclic complexes affects these properties. Four EuII-containing complexes were synthesized with different maximum-possible distances between the EuII ion and peripheral anionic groups of the ligand. Electrochemical potentials were measured using cyclic voltammetry, and dissociation rates were measured at pH 7 using an electrochemical method and at pH 1 using an acid-catalyzed dissociation method. Electrochemical studies show that increasing the maximum-possible distance between EuII and peripheral charges shifts electrochemical potentials to more positive values. Additionally, a decrease in the dissociation rates was observed at pH 7 with increasing maximum-possible distance. The EuII-containing complex with the largest maximum-possible distance exhibited the slowest dissociation rate. Statistical analysis confirmed that trends are significant. The findings are expected to provide a framework for the rational design of EuII-based contrast agents for magnetic resonance imaging in which redox accessibility and kinetic inertness can be fine-tuned independently by controlling the distance of peripheral charges from EuII.

New Publication!
“Controlling the Kinetic and Electrochemical Properties of EuII–Containing Complexes Using Peripheral Charges” in Inorganic Chemistry. #wsuchemistry #ChemSky #MRI

All Authors: Md Sydul Islam and Matt Allen @mattallen12345.bsky.social

doi.org/10.1021/acs....

Solution-Phase Electrochemical Characterization of Acyclic Complexes of Divalent Europium Lanthanides have useful electronic and magnetic properties that are often tuned through coordination chemistry using a variety of ligands, such as macrocyclic ligands or ligands with conjugated π-syst...

Congratulations to first author Elle Lewandowski! Her paper, “Solution-Phase Electrochemical Characterization of Acyclic Complexes of Divalent Europium" has been published in Inorganic Chemistry. #wsuchemistry #chemistryindetroit #lanthanides

pubs.acs.org/doi/10.1021/...

11 people all holding painted canvases at a paint party event

How does the Allen Lab celebrate the end of the semester? With a paint party of course! Matt Allen painted a closeup of europium, while the rest of the lab members all painted @mattallen12345.bsky.social 🎨 😂 #wsuchemistry #paintparty #chemistryindetroit

1 person sitting with a bouquet of flowers on a table

Morgan Deal passed her PhD Candidacy exam in the Allen Lab and is now an official PhD candidate. Congratulations, Morgan! #wsuchemistry #graduateresearch #chemistryindetroit #ChemSky

PhD student with their committee after defending their thesis

Please join us in congratulating Dr. Alexander Sertage. Yesterday, the Allen Lab member successfully defended his dissertation: "Advanced Lanthanide Probes for Magnetic Resonance Imaging and Computational Modeling” at #wsuchemistry. Congrats, Dr. Sertage! #PhDdone #chemistryindetroit
#ChemSky

Fantastic talk by Sethma!

Now that this is complete, I guess I can retire! (The missing ones aren’t available.)

Check out our latest pub on recovery of Gd after MRI.

A group of students and professors at Graduation Day at Wayne State University

Congratulations, graduates! 💚💛 #wsuchemistry #WarriorStrong🔰 #ClassOf2024 #wsustudents #chemistryphds #ChemSky

Now hiring: Analytical/organic chemistry tenure-track faculty Wayne State's Department of Chemistry invites applications for a tenure-track analytical or organic chemistry faculty position.

Wayne State University Chemistry invites applications for an Assistant Professor in Analytical or Organic Chemistry with a broad focus on interdisciplinary biomedical research. #wsuchemistry #scisky #chemjobber @chemjobber.bsky.social

Apply by 12/1/24

clas.wayne.edu/chemistry/ne...