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Miguel Paredes

@paredesmig

Working on Genomic Epidemiology & Phylodynamics. MD-PhD student at the University of Washington/Fred Hutch Cancer Center. He/him/Γ©l πŸ‡¨πŸ‡΄πŸ³οΈβ€πŸŒˆ

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10.09.2024
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Latest posts by Miguel Paredes @paredesmig

Cover of The Lancet, 28 February 2026 issue. The quote: β€œThe destruction that Kennedy has wrought in 1 year might take generations to repair, and there is little hope for US health and science while he remains at the helm.”

Cover of The Lancet, 28 February 2026 issue. The quote: β€œThe destruction that Kennedy has wrought in 1 year might take generations to repair, and there is little hope for US health and science while he remains at the helm.”

On the cover of The Lancet:
Editorial β€” β€œRobert F Kennedy Jr: 1 year of failure”

Read the latest issue: spkl.io/63327Aa31W

27.02.2026 07:28 πŸ‘ 578 πŸ” 314 πŸ’¬ 13 πŸ“Œ 42
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Tecovirimat for the Treatment of Mpox | NEJM Tecovirimat is approved for smallpox treatment under the Food and Drug Administration Animal Rule on the basis of efficacy in nonhuman primate models of mpox (previously known as monkeypox). Howeve...

The full results of the STOMP trial are now published in @nejm.org
Tecovirimat did not shorten time to symptom resolution or impact symptoms of clade II mpox. The findings are similar to PALM007 trial which found no beneficial effects of the drug for clade I mpox
www.nejm.org/doi/full/10....

25.02.2026 23:11 πŸ‘ 26 πŸ” 10 πŸ’¬ 2 πŸ“Œ 1
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Brilliant plenary on STI trends at #CROI2026. DoxyPEP implementation in Seattle shows indirect reductions of syphilis rates in cisgender women who are not the target group for the intervention. Shared sexual networks with men who are the target intervention group?

24.02.2026 16:28 πŸ‘ 39 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1
graph with age on the x-axis and population size on the y-axis. A curve indicates population size decreasing with age. It is shaded in orange under the curve.

graph with age on the x-axis and population size on the y-axis. A curve indicates population size decreasing with age. It is shaded in orange under the curve.

I use this (overly simplified) schematic to explain to folks why maintaining high measles immunity is so hard. Even with 100% coverage, you get different outcomes depending on who and when you vaccinate.

Consider a population with more kids than adults -- start with them all being susceptible.

22.02.2026 19:39 πŸ‘ 8 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0
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COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium COVID-19 vaccination with a booster reduces the odds of PE by 30% approaching 60% reduction among women with pre-existing morbidities.

COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium www.thelancet.com/journals/ecl...

21.02.2026 23:27 πŸ‘ 7 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Clinical and patient-reported outcomes of cutaneous leishmaniasis treatment in Ethiopia: A prospective, observational cohort study in two referral hospitals We ran a prospective cohort of patients with cutaneous leishmaniasis patients in Ethiopia. Regardless of treatment choice we observed poor cure rates at 90

Our Cutaneous Leishmaniasis cohort study in Ethiopia now out.

Most patients received Sodium Stibogluconate but we show this has an extremely low cure rates at end of treatment.

This data underpins our @globalhealthedctp3.bsky.social Multi-Arms-Multi-Stage trial to improve CL treatment.

18.02.2026 13:48 πŸ‘ 6 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
A valentine from Public Health of Seattle and King County. A man shivers in bed while a smiling lady in a red mask shows off her bandage on her arm.

Text: Noses are red
Ice packs are blue
I'm vaxed so miss me with severe symptoms of flu.

A valentine from Public Health of Seattle and King County. A man shivers in bed while a smiling lady in a red mask shows off her bandage on her arm. Text: Noses are red Ice packs are blue I'm vaxed so miss me with severe symptoms of flu.

A valentine from Public Health of Seattle and King County. Two lady scientists shrug lackadaisically. Text reads: My love for you can't be explained by science. Just like the new federal vaccine guidelines.

A valentine from Public Health of Seattle and King County. Two lady scientists shrug lackadaisically. Text reads: My love for you can't be explained by science. Just like the new federal vaccine guidelines.

A valentine from Public Health of Seattle and King County. Protesters in Minneapolis wear thick clothes and hold signs of support for immigrant neighbors. Text reads: To the health departments in the Twin Cities:
Love unites us.
Our hearts are with you.

A valentine from Public Health of Seattle and King County. Protesters in Minneapolis wear thick clothes and hold signs of support for immigrant neighbors. Text reads: To the health departments in the Twin Cities: Love unites us. Our hearts are with you.

Oh my GOD King County Public Health is just wilding out for Valentines Day (and a lovely one).

13.02.2026 23:51 πŸ‘ 1589 πŸ” 611 πŸ’¬ 9 πŸ“Œ 24
Mpox: recombinant virus with genomic elements of clades Ib and IIb – Global situation Recombination of monkeypox virus (MPXV) strains has been documented in recent months, with two cases of a recombinant strain comprising clade Ib and IIb MPXV reported. Recombination is a known natur...

#Mpox: recombinant virus with genomic elements of clades Ib and IIb - Global

www.who.int/emergencies/...

14.02.2026 21:06 πŸ‘ 17 πŸ” 8 πŸ’¬ 0 πŸ“Œ 2
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Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials Adverse event data from blinded randomised trials do not support causal relationships between statin therapy and most of the conditions (including cognitive impairment, depression, sleep disturbance, ...

The real story about statin safety from >122,000 RCT participants with individual level data. They can cause new-onset diabetes and muscle pain/weakness, but other than that they are remarkably safe for 62 outcomes. Rare liver function test abnormalities thelancet.com/journals/lan...

06.02.2026 15:47 πŸ‘ 115 πŸ” 27 πŸ’¬ 5 πŸ“Œ 0
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Statins don’t cause most of the side effects on package warnings, study finds Many people who should be taking statins avoid them for fear of side effects. A large new study says most of those side effects don't actually show up.

β€œWhat we found is there’s no significant excess risk with statins for almost all the conditions listed in statin packaging as potential side effects… We now have really good evidence that although these things may well happen to people while they take statins, that statins are not the cause”

06.02.2026 03:10 πŸ‘ 18 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
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Measles exposure reported in two University of Florida classes, university says The University of Florida and the Florida Department of Health in Alachua County are investigating potential measles exposure in two UF classes following two confirmed cases in the county.

Oh boy. β€œThe University of Florida and the Florida Department of Health in Alachua County are investigating potential measles exposure in two UF classes following two confirmed cases in the county.
Health officials have begun contacting individuals who may have been exposed.” @aetiology.bsky.social

06.02.2026 00:37 πŸ‘ 101 πŸ” 49 πŸ’¬ 8 πŸ“Œ 21
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Long-Term Mpox Sequelae 11 to 18 Months After Acute Illness: A Cohort Study in Two U.S. Cities: Annals of Internal Medicine: Vol 0, No 0 Background: Little was known about persistent sequelae of mpox before the 2022 multinational clade II mpox virus outbreak. Objective: To characterize post-mpox sequelae 11 to 18 months after acute mpo...

Mpox cohorts from NYC and Houston.

Conclusion:
Post-mpox sequelae frequently persisted 11 to 18 months after acute mpox, with limited body distribution or physical morbidity but with continued social and sexual effects.

www.acpjournals.org/doi/10.7326/... #IDSky

19.01.2026 23:10 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective... Universal infant nirsevimab prophylaxis markedly reduced RSV-related hospitalisations and outpatient morbidity, with sustained reductions in RSV-related LRTI hospitalisations into the second season an...

The NIRSE-GAL study looking at real world impact of nirsevimab in infants in Spain.

Of 12 492 eligible infants, 94Β·4% received immunization. RSV-related LRTI hospitalisations decreased by 85Β·9% in the 1st season and 55Β·3% in the 2nd.

www.thelancet.com/journals/lan... #IDSky

13.01.2026 14:07 πŸ‘ 5 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1
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20 out of 25 CIO director positions at CDC are vacant and filled by actings (or eliminated), just in the past year via CDC Data Project www.cdcdataproject.org/leadership-c...

10.01.2026 19:18 πŸ‘ 132 πŸ” 73 πŸ’¬ 6 πŸ“Œ 7

Sharing this personal Op-Ed again given the abrupt and unjustified changes to the childhood vax schedule (www.statnews.com/2026/01/05/c...). The schedule protects not only the kiddos but their family and community too. The schedule should be guided by impartial evidence, not blatant political gain

05.01.2026 23:25 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
The challenge to those of us in public health is not just to speak out but to be active proponents of nonviolence and peacemaking. This means taking an abolitionist view of sorts, in which we work toward a world in which violence is a thing of the past. I am not naΓ―ve enough to think that this is an achievable goal right now, but that must be our ultimate aim, or we will remain complicit in some way.

The challenge to those of us in public health is not just to speak out but to be active proponents of nonviolence and peacemaking. This means taking an abolitionist view of sorts, in which we work toward a world in which violence is a thing of the past. I am not naΓ―ve enough to think that this is an achievable goal right now, but that must be our ultimate aim, or we will remain complicit in some way.

Talking with my colleagues from around the world and thinking, as I do often these days, about this quote from my colleague @gregggonsalves.bsky.social, which articulated something that I think many of us know but is rarely said with this clarity. www.thenation.com/article/acti...

04.01.2026 02:00 πŸ‘ 97 πŸ” 18 πŸ’¬ 3 πŸ“Œ 0
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Effectiveness of 2024–2025 COVID-19 Vaccines in Children... This report describes COVID-19 vaccine effectiveness among children ages 9 months to 17 years.

www.cdc.gov/mmwr/volumes... #IDSky #COVID #vaccines

11.12.2025 18:25 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The Incubation Periods of Mpox Virus Clade Ib | Annals of Internal Medicine Background: Mpox virus (MPXV) clade Ib, first detected in the Democratic Republic of the Congo (DRC) in September 2023, spread internationally within months, prompting an emergency declaration from th...

In this analysis of clinical surveillance data, the median incubation period from exposure to rash was 13.6 days.

Sexual transmission had a shorter median (10.3 days [CrI, 3.1 to 20.3 days]) than nonsexual transmission (13.5 days [CrI, 9.5 to 19.1 days]).

www.acpjournals.org/doi/10.7326/...

09.12.2025 02:09 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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England health officials identify newly evolved variant of mpox Virus caught by person who travelled to Asia combines more severe form of mpox with less virulent type

A recombinant strain of mpox virus has been isolated from a patient in the UK containing fragments of clade I and clade II virus. Recombination occurs when two strains of virus infect a cell. These events tend to be rare but are well described in poxviruses.
www.theguardian.com/world/2025/d...

08.12.2025 17:47 πŸ‘ 69 πŸ” 21 πŸ’¬ 3 πŸ“Œ 0
A diagram of the enrollment, randomization, and follow-up.

A diagram of the enrollment, randomization, and follow-up.

In a new trial, one dose of an HPV vaccine was noninferior to two doses in preventing HPV type 16 or 18 infection. Full ESCUDDO trial results: nej.md/49OEzg1

Editorial: Evidence to Action β€” Single-Dose HPV Vaccination and Cervical HPV Infection nej.md/3XsH9Rx

#MedSky #IDSky

03.12.2025 22:25 πŸ‘ 26 πŸ” 14 πŸ’¬ 1 πŸ“Œ 3
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Because of the hepatitis B birth dose and completion of the infant series of the vaccine, the U.S. has made significant progress in reducing chronic hepatitis B. Eliminating the birth dose would reverse this progress and put children's health at risk. Read more:

www.aap.org/en/news-room...

02.12.2025 21:44 πŸ‘ 66 πŸ” 27 πŸ’¬ 2 πŸ“Œ 1
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β€œSince 1998, independent researchers have conducted more than 40 high-quality studies involving over 5.6 million people. The conclusion is clear and unambiguous: There’s no link between vaccines and autism." -Dr. Susan Kressly, AAP President on recent changes to the CDC's website

20.11.2025 15:24 πŸ‘ 597 πŸ” 303 πŸ’¬ 7 πŸ“Œ 8
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Firearm Homicide in Pregnant Women and State-Level Firearm Ownership This cross-sectional study examines firearm homicide rates in pregnant compared with nonpregnant women and whether estimated state-level firearm ownership is associated with homicide deaths among preg...

New paper reminds us yet again: HOMICIDE is the leading cause of death for pregnant women.

Gun violence & partner violence are related.

All-cause homicide & firearm homicide of pregnant women are higher, in states w/ higher calculated firearm ownership (1/x 🧡

jamanetwork.com/journals/jam...

17.11.2025 03:15 πŸ‘ 314 πŸ” 123 πŸ’¬ 7 πŸ“Œ 8
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Ecology and spread of the North American H5N1 epizootic - Nature The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...

Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...

12.11.2025 19:33 πŸ‘ 139 πŸ” 66 πŸ’¬ 6 πŸ“Œ 7
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Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study Individuals previously infected with MPXV show strong and durable immunological memory lasting up to 2 years after infection, in contrast to the less robust and shorter-lived response observed after M...

A fascinating new Lancet ID paper offers the strongest comparative evidence yet between infection-induced and vaccine-induced immunity against mpox. The study followed people for up to 2 years after infection with monkeypox virus or vaccination with MVA-BN. #IDsky
www.thelancet.com/journals/lan...

09.11.2025 13:15 πŸ‘ 45 πŸ” 12 πŸ’¬ 3 πŸ“Œ 1
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Esto merece ser destacado mil veces ☝️

23.10.2025 23:16 πŸ‘ 78 πŸ” 58 πŸ’¬ 5 πŸ“Œ 4

With millions at risk of losing SNAP in the coming days, a reminder: hunger doesn't happen in isolation. When food assistance disappears, families use rent money to eat. Then come evictions and homelessness.

Housing, food, healthcareβ€”it's all connected. Cut one thread and the whole thing unravels.

24.10.2025 12:26 πŸ‘ 6749 πŸ” 3064 πŸ’¬ 200 πŸ“Œ 138
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Three cases of severe mpox reported in California, health officials say Unrelated cases mark first time clade I of disease formerly known as monkeypox has spread within US, officials say

Three cases of clade Ib mpox not related to travel have been reported in LA. This raises concerns for probable local transmission. Vaccines are available and work to reduce disease severity or prevent infection. If you are eligible to get vaccinated do so.
www.theguardian.com/us-news/2025...

21.10.2025 15:28 πŸ‘ 55 πŸ” 29 πŸ’¬ 1 πŸ“Œ 0
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Ebola virus in Kasai revives 50-year-old questions on viral latency On Sept 4, 2025, DR Congo declared its 16th Ebola virus outbreak. The epicentre of this outbreak occurred in the Kasai provinceβ€”the first resurgence in this region since 2008.1 Genomic analysis identi...

Ebola virus in Kasai revives 50-year-old questions on viral latency www.thelancet.com/journals/lan...

17.10.2025 20:32 πŸ‘ 7 πŸ” 3 πŸ’¬ 1 πŸ“Œ 2