RTG 2355

Tho1 and MOS11 promote nucleic acid double-strand unwinding by facilitating DEAD-box helicase oligomerization Abstract. DEAD-box helicases are essential for gene expression and RNA metabolism. However, the mechanisms regulating their activity remain largely elusive

Happy to share the work by Fabienne Becker et al in #NAR, showing how yeast Tho1-CTD stimulates helicase activity of Sub2, homologue of human DDX39B/UAP56, by promoting Sub2 oligomerization on RNA. The scaffolding mechanism is shared across species:

academic.oup.com/nar/article/...

Happy to announce our RTG 2355 International Conference “Regulatory landscapes of RNA: From code to control”, Sept 14-16, 2026 in Giessen, Germany. Topics cover #RNA as messenger, recruiting platform, sponge, regulator & sensor. 👉tinyurl.com/rtg2355conf

Save the date – registration opens May 1!

Gruppenfoto mit etwa 30 Personen: LEAF-Preisträgerinnen und -Preisträger draußen im Innenhof des modernen Chemiegebäudes der JLU.

#jlugiessen zeichnet erstmals drei Forschungslabore mit #LEAF-Zertifikat für nachhaltige Laborpraxis aus. Prämiert wurden drei Arbeitsgruppen in #OrganischeChemie und #AnorganischeundAnalytischeChemie. Glückwunsch!
#nachhaltigkeit #LEAF
www.uni-giessen.de/de/ueber-uns...

Foto: Katrina Friese

Max Planck Postdoc Program Launching in April 2025, the Max Planck Postdoc Program features structured application calls and a comprehensive support system for researchers.

Looking to do a postdoc? Explore this fantastic opportunity to do a postdoc at a Max Planck institute. Applications for this program are due by October 13, 2025.

hashtag#maxplancksociety hashtag#postdoc
www.mpg.de/en/max-planc...

🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...

@rtg2355.bsky.social PhD candidate Fabienne Becker from the Friedhoff lab recently presented her work on nucleic acid double strand unwinding by Sub2 & UAP56 DEAD-box helicases at the 2025 GGL conference @jlugiessen.bsky.social - the corresponding manuscript is close to resubmission! 😉

Very timely review for those of you who have been following all of the recent developments in this area... also @cp-trendsbiochem.bsky.social why can't we share via bsky directly from the article???

A book cover with a strand of RNA on a pink background, with the title, authors name, and publisher.

I did a thing. I wrote a textbook about #RNA. I wrote it so that those without formal science training could understand what RNA is and how it is used in medicine. It releases in the US and Europe on September 8th. www.worldscientific.com/worldscibook...

Forschungsdesign - Wissenschaftliche Integrität Wissenschaftler*innen berücksichtigen bei der Planung eines Vorhabens den aktuellen Forschungsstand umfassend und erkennen ihn an. Die Identifikation relevanter und geeigneter Forschungs- fragen setzt sorgfältige Recherche nach bereits öffentlich zugänglich gemachten Forschungsleistungen voraus....

#Forschungsdesign bedeutet u. a. den aktuellen Forschungsstand zu berücksichtigen, vorhandene Forschungsleistungen einzubeziehen und unbewusste Verzerrungen zu vermeiden. Leitlinie 9 der #GWP erläutert diese Grundsätze im Detail:
https://www.wissenschaftliche-integritaet.de/kodex/forschungsdesign/

Mathematical modelling for biologists - Modelling concepts in biological research Mathematical modelling for biologists - Modelling concepts in biological research

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology:
www.ebi.ac.uk/training/onl...

Including both molecular and epidemiological examples

Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene The gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of its adaptation to antibiotics, we anal...

New paper out by RTG2355 members Jennifer Kothe, Theresa Dietz, Robina Scheuer & Elena Evguenieva-Hackenberg, identifying a new attenuation mechanism that apparently monitors ribosome availability and translation efficiency in the soil bacterium Sinorhizobium meliloti

Postdoc in Structural Biology of RNA processing complexes Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...

Postdoc positions in structural biology of RNA processing complexes.

An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.

Details: tinyurl.com/postdoc-RNA-...

And here goes another one - @rtg2355.bsky.social-member Fabienne Becker from the Friedhoff lab presented her research at the 2025 Helicase Conference in Lisbon today: "The Conserved C-terminal Domain of Tho1 Stimulates the DEAD-box Helicase Sub2" - more coming soon #proudCoordinator 😉

Proudly presenting one of our associated PhD candidates @rtg2355.bsky.social - go Palina!

September Science Academy The September Science Academy for microbial and molecular biosciences is a fully funded international summer school for women in science and scientists of underrepresented genders in an advanced stage of their PhD or an early postdoctoral stage. Hosted by the Max Planck Institute for Terrestrial Microbiology in Marburg, the program invites early-career scientists from all over the world to explore cutting-edge research, connect with the institute’s scientific community, and discover new career opportunities.

✨ Deadline extended! There’s still time to apply: September Science Academy - international summer school for women in the molecular life sciences. Deadline: July 14, 📍 Marburg, Germany
www.mpi-marburg.mpg.de/1489492/Sept...
#WomenInSTEM #SummerSchool

.. excellent talks by our doctoral candidates, and a wonderful poster session in the back yard.

Many thanks to all participants for making this retreat such a nice experience, especially to our fantastic invited experts!

.. a hike through beautiful scenery with a guided tour to the local castle ruins by @jochenschau.bsky.social ..

Back from another great retreat to Schmitten, Taunus - this year with guests from @4r-rtg.bsky.social and from @jlugiessen.bsky.social and @mpi-hlr.bsky.social core facilities. We had inspiring method sessions on scientific diagrams & statistics, complexome proteomics, microscopy & image analysis ..

🚨 We’re hiring ! 🚨
Join our cutting-edge research team as a molecular biologist at @nanoporetech.com HQ in Oxford.
Perfect for a fresh PhD or MSc with a couple of years’ experience. Work at the interface of chemistry, molecular/synthetic biology and AI

👉 ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...

Courses coming soon Find out about research training online courses that will be available soon on the Nature Masterclasses on-demand platform. Learn from experts.

Choosing the Best Journal for Your Paper - An upcoming webinar from Nature Masterclasses:
masterclasses.nature.com/courses-comi...

RTG PIs Katharina Höfer and Katja Sträßer presented recent research from their labs at the RNA Society Conference in San Diego.

Salary negotiations: a guide for scientists Seasoned negotiators share tips on how to handle conversations around pay, bonuses, benefits and contract length.

Latest from the Nature Careers Podcast 🔊 Salary negotiations: a guide for scientists

www.nature.com/articles/d41...

A great overview of methods to investigate RNA modifications 😊
onlinelibrary.wiley.com/doi/full/10....

Wow! This is an exciting and important action!

Eine Medizinstudierende "untersucht" oder operiert in der Teddyklinik das Stofftier eines kleinen Mädchen. Im Vordergrund ist im Profil ein weiteres Mädchen zu stehen, das mit ihrem Stoffhund auf die Untersuchung wartet.

Plüsch-Patienten willkommen: #Teddyklinik Gießen öffnet ihre Tore. Kinder dürfen vom 3. bis 6. Juni 2025 ihre Stofftiere und Puppen von Medizinstudierenden verarzten lassen
www.uni-giessen.de/de/ueber-uns...

Hundreds of research grants at Columbia canceled following Trump edict, administrator says The National Institutes of Health is terminating 232 grants for scientific research at Columbia University Irving Medical Center, according to an email an administrator sent to faculty.

I received one of the 232 NIH grant "terminations" sent to scientists at Columbia last night. My research focuses on improving maternal and child health in the US. Also affected: ongoing clinical trials, research training programs, and research centers that aim to improve the health of Americans.

🎉 > 2000 Zeichnungen!

www.bayceer.uni-bayreuth.de/s4f/de/top/o...

Another Dr. from our RTG - Ebru Aydin from @kilchertlab.bsky.social successfully defended her thesis yesterday. Congratulations, Ebru! 🎓And a great party, too 🥳🍾🥂

Open PhD position in our RTG2355 - great diversity in topics, invited speakers, retreats and symposia, workshops, soft skill courses - and very nice people!

Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene The Gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of its adaptation to antibiotics, we analyze...

Excited to share the work of Jennifer Kothe et al suggesting a mechanism to be used by bacteria for fine-tuning gene expression according to ribosome availability and translation efficiency: www.biorxiv.org/content/10.1...