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Mathias Guayasamin

@mathiasgua

PhD candidate in neurobiology and apprentice star-whisperer with the Murphy-Royal team πŸš΄πŸ½β€β™‚οΈ The work is mysterious and important

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14.11.2024
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Latest posts by Mathias Guayasamin @mathiasgua

Screenshot of email that says β€œnew preprint finds that in the basolateral amygdala, "astrocytic activity provides a stable and scalable representation of threat-induced anxiety across an array of behavioral tasks."

Screenshot of email that says β€œnew preprint finds that in the basolateral amygdala, "astrocytic activity provides a stable and scalable representation of threat-induced anxiety across an array of behavioral tasks."

Nice surprise today in @thetransmitter.bsky.social daily email linking our preprint!
Thank you! 😍

mailchi.mp/thetransmitt...

22.01.2026 12:33 πŸ‘ 17 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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🚨Registration for the N American stress meeting is now open!!🚨

Really excited to be part of it and host the event in the @crchum.bsky.social in MontrΓ©al this June!

www.stress2026.com/registration

15.01.2026 14:18 πŸ‘ 13 πŸ” 7 πŸ’¬ 0 πŸ“Œ 4
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Astrocytic Encoding of Threat in the Basolateral Amygdala The basolateral amygdala (BLA) has long been implicated in threat detection and the generation of anxiety states. While previous experiments have demonstrated the important role of BLA principal neuro...

Delighted to share our first preprint of the year!

A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...

08.01.2026 19:58 πŸ‘ 52 πŸ” 19 πŸ’¬ 4 πŸ“Œ 0
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Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms How does the brain balance innate responses with adaptive learning when reacting to threats? This study shows that repeated exposure to looming stimuli reduces innate defensive responses via hippocamp...

Starting 2026 with a thread a very recent manuscripts at Ryan Lab @tcddublin.bsky.social @tbsi-tcd.bsky.social

"Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms"
journals.plos.org/plosbiology/...

@PLOSBiology

02.01.2026 16:34 πŸ‘ 58 πŸ” 20 πŸ’¬ 3 πŸ“Œ 0
Mathias giving his presentation in an amphitheatre

Mathias giving his presentation in an amphitheatre

Fantastic presentation from @mathiasgua.bsky.social at @umontreal.ca Neuro department research day.

Showing all his cool new data!

10.12.2025 14:22 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Fish keratocytes isolated from a fish scale crawling around. Technique: DIC microscopy. #CellBiology.
Another #NikonSmallWorldReject

11.10.2025 20:14 πŸ‘ 53 πŸ” 9 πŸ’¬ 2 πŸ“Œ 1
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Reproducibility is a team sport Building reproducible systems across labs is possible, even in large-scale neuroscienceβ€”with rigor and collaboration.

"Reproducibility isn’t glamorous, but it’s essential."

@annechurchland.bsky.social speaks candidly in @thetransmitter.bsky.social about the obstacles to reproducibility and shares practical advice for other neuroscience labs.

πŸ§ πŸ“ˆ www.thetransmitter.org/reproducibil...

08.10.2025 20:53 πŸ‘ 48 πŸ” 11 πŸ’¬ 1 πŸ“Œ 1

Thrilled to have received my first ever poster prize last week at EBBS2025 in Bordeaux πŸ„β€β™‚οΈ! Cherry on top was that I actually did my master’s in Bordeaux a few years ago and saw many friendly faces during that (VERY) hot week.

07.07.2025 13:41 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Post image Post image 4 scientists posing on a boat

4 scientists posing on a boat

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Part 2 of France trip done.
Fantastic @ebbsociety.bsky.social meeting with PhD students from the lab! Topping it off with a presentation prize for @mathiasgua.bsky.social !! πŸ₯³

01.07.2025 18:17 πŸ‘ 16 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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#fluorescencefriday
picture I took a few months ago with our 2P of pyramidal neurons in the lateral amygdala expressing a lactate sensor πŸ‘½

title: Paths of fear

06.06.2025 15:25 πŸ‘ 23 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Screenshot of article summary of: Toward Science-Led Publishing
by Damian Pattinson, George Currie

published as an opinion piece, in Learned Publishing

Summary

The current dynamic of scholarly publishing prioritises the wants of the publishing industry over the needs of the research community.

This article explores this theme through the lens of β€˜publisher-led science’ as a description of our current status quo, and through β€˜science-led publishing’ as an improved future state.

We argue that financial motivations central to most publishing distort how research is presented, how it is assessed and even what research is undertaken, leading to a system that hinders, rather than facilitates, scientific progress.

We propose three elements of a science-led publishing approach that would accelerate research communication, incentivise collaboration between authors, editors and reviewers, and create a more transparent and equitable research landscape.

We believe that research funding and research assessment are two of the primary levers for wider change in research and research culture and consider the future purpose of scholarly publishing in a world where these proposals have been widely adopted.

Screenshot of article summary of: Toward Science-Led Publishing by Damian Pattinson, George Currie published as an opinion piece, in Learned Publishing Summary The current dynamic of scholarly publishing prioritises the wants of the publishing industry over the needs of the research community. This article explores this theme through the lens of β€˜publisher-led science’ as a description of our current status quo, and through β€˜science-led publishing’ as an improved future state. We argue that financial motivations central to most publishing distort how research is presented, how it is assessed and even what research is undertaken, leading to a system that hinders, rather than facilitates, scientific progress. We propose three elements of a science-led publishing approach that would accelerate research communication, incentivise collaboration between authors, editors and reviewers, and create a more transparent and equitable research landscape. We believe that research funding and research assessment are two of the primary levers for wider change in research and research culture and consider the future purpose of scholarly publishing in a world where these proposals have been widely adopted.

Does publishing serve science or is science serving publishing?

Damian Pattinson and I (@elife.bsky.social) argue scientific publishing has evolved into a system that, rather than facilitate scholarly communication, distorts and dictates it.

onlinelibrary.wiley.com/doi/10.1002/...

#OpenScience

19.05.2025 14:52 πŸ‘ 71 πŸ” 39 πŸ’¬ 4 πŸ“Œ 8
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Norepinephrine signals through astrocytes to modulate synapses Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Thought this would be a nice way to enter the bsky communityπŸ‘‡Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...

16.05.2025 04:34 πŸ‘ 57 πŸ” 21 πŸ’¬ 4 πŸ“Œ 2
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This is a new image from #JWST.

The bright points with spikes are stars in the Milky Way.

Everything else is a galaxy.

Everything. Else. Is. A. Galaxy.

29.04.2025 18:47 πŸ‘ 18916 πŸ” 4056 πŸ’¬ 616 πŸ“Œ 474
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Great seminar from @lewisholt.bsky.social today at the @crchum.bsky.social !
Part of the β€˜exit seminar’ as he closes in on the finish line of his PhD πŸ₯²

29.04.2025 14:27 πŸ‘ 10 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Astrocytic CREB: The Hidden Driver of Stress Susceptibility

Happy to share the commentary "Astrocytic CREB: The Hidden Driver of Stress Susceptibility" @mathiasgua.bsky.social and I put together for Biological Psychiatry www.sciencedirect.com/science/arti...

09.04.2025 10:46 πŸ‘ 20 πŸ” 8 πŸ’¬ 1 πŸ“Œ 1
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Program for the "Neural Circuits and Behaviour" CAN 2025 satellite is now available! We have a great day planned, and are especially looking for trainees to join the event - we'll select four trainees for talks, with a prize for best trainee talk. Details: www.eventbrite.ca/e/neural-cir...

24.03.2025 20:39 πŸ‘ 20 πŸ” 8 πŸ’¬ 1 πŸ“Œ 0

Thank you!!! This is from a wildtype c57/b6 that we injected with a lckGCaMP6 viral vector.

14.02.2025 19:37 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thank you!!!! This is a calcium sensor so all the flashes we see are calcium events. This is in an acute brain slice :)

14.02.2025 19:36 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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#FluorescenceFriday
Title: Solar Flare

Lateral amygdala astrocyte going about its daily routine

14.02.2025 16:35 πŸ‘ 16 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

SUPER happy that the newest version of our preprint is finally sailing the seas on biorxiv 🀩
Quite a journey where we explored the impact of early-life-stress on fear memory specificity, neuronal circuits in the lateral amygdala and the astrocytes that regulate them 🌟

10.12.2024 01:23 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

I was wondering about the absence of glasses!

05.12.2024 22:47 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

iBiology is a REMARKABLE and under-utilized resource for learning from some of the pioneers of microscopy--these videos are suitable for undergraduate classes or experts πŸ§ͺ

17.11.2024 00:19 πŸ‘ 182 πŸ” 42 πŸ’¬ 10 πŸ“Œ 3
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#FluorescenceFriday
2-photon calcium imaging recording from a magestic astrocyte.
Title: twinkle twinkle little star

15.11.2024 16:56 πŸ‘ 39 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0