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SchmitzStreitsLAB

@schmitzstreitslab

We are interested in #archaea,#regulation,#ncRNA,#smallproteins & novel biomolecules from nature, CAU Kiel https://www.mikrobio.uni-kiel.de/de/ag-schmitz-streit Views are our own

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17.01.2025
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Latest posts by SchmitzStreitsLAB @schmitzstreitslab

If you love RNA and RNA machineries as much as we do at @uniregensburg.bsky.social we encourage young scientists who want to start their own lab to apply.

04.03.2026 13:57 πŸ‘ 0 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling - Nature Microbiology A structural catalogue of the Asgard archaeal pangenome reveals hundreds of eukaryotic-like proteins that suggest a higher degree of cellular complexity in the archaeal ancestor of eukaryotes.

🧡 1/10 New paper out in @natmicrobiol.nature.com from my postdoc at @mib-wur.bsky.social! πŸŽ‰

How eukaryote-like was the archaeal ancestor of eukaryotes? Sequence searches alone can't tell us β€” so we used protein structure prediction to look deeper. 🧬
www.nature.com/articles/s41...

05.03.2026 10:46 πŸ‘ 64 πŸ” 34 πŸ’¬ 3 πŸ“Œ 3
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#OnThisDay in 1938, American evolutionary biologist Lynn Margulis was born. Margulis is most known for developing and popularising the endosymbiotic theory, which explains how eukaryotic cells evolved organelles from simpler prokaryotic organisms that resided within another and became incorporated.

05.03.2026 18:02 πŸ‘ 36 πŸ” 12 πŸ’¬ 2 πŸ“Œ 2
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Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling Nature Microbiology, Published online: 05 March 2026; doi:10.1038/s41564-026-02273-yA structural catalogue of the Asgard archaeal pangenome reveals hundreds of eukaryotic-like proteins that suggest a higher degree of cellular complexity in the archaeal ancestor of eukaryotes.

Out Now! Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling #MicroSky

06.03.2026 03:03 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Job Details

Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n

05.03.2026 21:35 πŸ‘ 85 πŸ” 123 πŸ’¬ 2 πŸ“Œ 3

This is a fantastic paper with a very creative computational approach, that should inspire many "AlphaFlod-predicted shapes" screens.
Great friday read πŸ“–πŸ“–

06.03.2026 13:05 πŸ‘ 15 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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🦠 Beyond classic probiotics: @schmitzstreitslab.bsky.social lab reveals diverse #Bacteroidota gut strains that block #biofilms of major pathogens. Many also disrupt quorum sensing & show bile salt hydrolase activityβ€”expanding the #microbiome toolbox against infection.

πŸ‘‰ buff.ly/sjPk8ZD

03.03.2026 08:00 πŸ‘ 4 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Unraveling posttranscriptional regulatory networks in phage infection Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…

Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!

tinyurl.com/lambda-RIL-seq

26.02.2026 13:29 πŸ‘ 33 πŸ” 20 πŸ’¬ 1 πŸ“Œ 2
Assistant/Associate/Full Professor Computational Biology Assistant/Associate/Full Professor Computational Biology

Join us as Assistant/Associate/Full Professor Computational Biology at Institute of Biology Leiden (IBL) / @leidenscience.bsky.social / @unileiden.bsky.social

Application deadline on 15 March 2026
πŸ‘‡
careers.universiteitleiden.nl/job/Assistan...

26.02.2026 10:52 πŸ‘ 21 πŸ” 22 πŸ’¬ 0 πŸ“Œ 0

Rapid modular evolution of antiviral repertoires in P2 phages and their P4 satellites: shuttling, swapping and mixing https://www.biorxiv.org/content/10.64898/2026.02.27.708500v1

01.03.2026 03:17 πŸ‘ 12 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA WΓΌrzburg, Bavaria.

08.10.2025 21:45 πŸ‘ 68 πŸ” 80 πŸ’¬ 1 πŸ“Œ 1
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Women's Talk Marathon For the fifth time, the women of Kiel University present their work on March, 6th 2026 β€” two days before international women's day.

πŸ“’ Save the date! The women's talk marathon is back. On Friday 6 March 2026, women from Kiel University β€” students, staff and professors β€” will discuss their work and experiences in academia. πŸ‘©πŸ”¬
#WomenInScience #ConnectingHorizons

23.02.2026 16:00 πŸ‘ 5 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1

If you are looking for β€œmore”, apply for this outstanding PhD program which offers you ample opportunities to develop as a scientist and leader connecting to peers, leaders in the RNA field in Germany, Europe and around the world. Learn the science but also about translation into applications.

23.02.2026 22:20 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Congratulations to Sonomi Yamaguchi for her paper at @nature.com. Sonomi discovered Clover defense and explained how nucleotide signals control each step of viral sensing, immune regulation, and viral restriction – named for her beautiful "four-leaf" structures πŸ€

www.nature.com/articles/s41...

18.02.2026 17:11 πŸ‘ 59 πŸ” 31 πŸ’¬ 0 πŸ“Œ 4
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Our latest preprint: Together with the team of Jan LΓΆwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...

16.02.2026 16:43 πŸ‘ 134 πŸ” 61 πŸ’¬ 3 πŸ“Œ 4

We are happy to share our newest preprint on a novel strain of Ca. Lokiarchaeum ossiferum, that contains an active provirus, capable of excision and independent replication! We propose a novel virus family: Fylgjaviridae.

www.biorxiv.org/content/10.6...

16.02.2026 21:06 πŸ‘ 35 πŸ” 18 πŸ’¬ 1 πŸ“Œ 1

my.corehr.com/pls/uoxrecru...
Two Postdoctoral Research Associates in the Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis

BEN BERKS lab 🀩

17.02.2026 18:20 πŸ‘ 5 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ETπŸ”¬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv πŸ“–: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧡

10.02.2026 08:35 πŸ‘ 154 πŸ” 54 πŸ’¬ 4 πŸ“Œ 6
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Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

www.sciencedirect.com/science/arti... #phage #bacteriophage #MicroSky

07.02.2026 19:26 πŸ‘ 24 πŸ” 14 πŸ’¬ 1 πŸ“Œ 0
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Tenure-Track Assistant Professor / Associate Professor in Bioinformatics and/or Computational Biology at Aarhus University, Denmark - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… https://nat.au.dk/en/about-the-faculty/vacant-positions-and-career/job/tenure-track-assistant-professor-associate-professor-in-bioinformatics-and-or-computational-biology-at-aarhus-university-denmark #job

07.02.2026 23:11 πŸ‘ 19 πŸ” 33 πŸ’¬ 0 πŸ“Œ 0

Archaea , archaea everywhere ☺️!

04.02.2026 17:58 πŸ‘ 9 πŸ” 3 πŸ’¬ 0 πŸ“Œ 1
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Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection.

www.nature.com/articles/s41...
www.nature.com/articles/s41...

04.02.2026 18:24 πŸ‘ 54 πŸ” 27 πŸ’¬ 1 πŸ“Œ 1
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The paradox of immune systems conservation between prokaryotes and eukaryotes - Nature Reviews Microbiology The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in eukaryotes, whereas relatively rare ones, such as Arg...

Aude Bernheim @audeber.bsky.social and Eugene Koonin discuss one of most interesting questions in the field connecting bacterial and animal immunity!

www.nature.com/articles/s41...

06.02.2026 15:15 πŸ‘ 79 πŸ” 40 πŸ’¬ 3 πŸ“Œ 1

Fantastic team effort of several groups in the SPP2002 @dfg.de and a brilliant PhD - Eva Herdering in the Kiel team @schmitzstreitslab.bsky.social

31.01.2026 12:23 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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🧬 Dive into the small proteome of Methanosarcina mazei (across 5 conditions)! A key resource by @schmitzstreitslab.bsky.social @uni-kiel.de for uncovering #smallproteins functions, motifs and proteoforms in #archaea.

πŸ‘‰ buff.ly/HJOi3E0

31.01.2026 10:01 πŸ‘ 11 πŸ” 4 πŸ’¬ 0 πŸ“Œ 2
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Institut Pasteur (@pasteur.fr) is recruiting new young PIs to open new groups in the Institute. Deadline is February 9th! Don't miss the opportunity!

27.01.2026 18:56 πŸ‘ 34 πŸ” 49 πŸ’¬ 0 πŸ“Œ 0
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Full Professor and Chair Laboratory of Biophysics We are looking for a Full Professor in the Biophysics chair group, part of Wageningen University & Research (WUR)

www.wur.nl/en/vacancy/f...

Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!

28.01.2026 05:20 πŸ‘ 23 πŸ” 48 πŸ’¬ 0 πŸ“Œ 0
Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases Many bacterial defense systems restrict phage infection by breaking the molecule NAD+ to its constituents, adenosine diphosphate ribose (ADPR) and nicotinamide (Nam). To counter NAD+ depletion-mediated defense, phages evolved NAD+ reconstitution pathway 1 (NARP1), which uses ADPR and Nam to rebuild NAD+. Here we report a bacterial defense system called aRES, involving RES-domain proteins that degrade NAD+ into Nam and ADPR-1β€³-phosphate (ADPR-1P). This molecule cannot serve as a substrate for NARP1, so that NAD+ depletion by aRES defends against phages even if they encode NARP1. We further discover that some phages evolved an extended NARP1 pathway capable of overcoming aRES defense. In these phages, the NARP1 operon also includes a specialized phosphatase, which dephosphorylates ADPR-1P to form ADPR, a substrate from which NARP1 then reconstitutes NAD+. Other phages encode inhibitors that directly bind aRES proteins and physically block their active sites. Our study describes new layers in the NAD+-centric arms race between bacteria and phages and highlights the centrality of the NAD+ pool in cellular battles between viruses and their hosts. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, ERC-AdG GA 101018520 Israel Science Foundation, MAPATS grant 2720/22 Deutsche Forschungsgemeinschaft, SPP 2330, grant 464312965 Minerva Foundation with funding from the Federal German Ministry for Education and Research research grant from Magnus Konow in honor of his mother Olga Konow Rappaport Ministry of Aliyah and Immigrant Absorption, https://ror.org/05aycsg86 Clore Scholars Program

We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense

Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap

A thread 🧡

29.01.2026 15:34 πŸ‘ 46 πŸ” 15 πŸ’¬ 2 πŸ“Œ 0
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Let’s get this started and on an RNA high πŸ˜…

26.01.2026 15:47 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems - Nature Communications Extracellular contractile injection systems (eCISs) are bacteriophage tail-derived toxin delivery complexes that are present in many prokaryotes. Here, the authors present an analysis of eCIS tail fib...

A new paper from the lab on virus-like particles called eCISs www.nature.com/articles/s41...

How bacteria evolved thousands of precision nanoinjectors?

Some bacteria don’t secrete toxins β€” they inject them using phage-derived machines called extracellular contractile injection systems (eCISs).

26.01.2026 13:26 πŸ‘ 41 πŸ” 27 πŸ’¬ 3 πŸ“Œ 0