Judith Agudo

Researchers led by Ludwig @harvard.edu’s @judithagudo.bsky.social Monica Cassandras & Xavier Sanchez have identified in preclinical studies a mechanism metastasizing triple-negative breast cancer cells engage to thwart immune attack & a drug that could disrupt it to curtail metastasis bit.ly/4r7kJBp

Thanks for highlighting our work and your kind words☺️

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding - Nature Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

www.nature.com/articles/s41...
The seeds of metastasis harness stress hormones to escape immune surveillance. So proud of this work! @harvardmed.bsky.social @danafarbernews.bsky.social @dfcibreastonc.bsky.social

Judith Agudo, PhD. of Dana-Farber Cancer Institute

New research published by @danafarber.bsky.social’s Judith Agudo, PhD, and colleagues in @nature.com today reveals a new strategy to prevent the metastasis of triple-negative breast cancer.

➡️ bit.ly/4rLuOFj

Why cancer can come back years later — and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Why does cancer come back after years of remission? @nature.com shares how researchers are uncovering what causes dormant tumor cells to reawaken. @judithagudo.bsky.social offered insights into why tumor cells may enter dormancy as a protective mechanism. Read more: bit.ly/4btv5Y6

Seeing Is Believing | Dana-Farber Cancer Institute Technicolor images of tumor samples are changing cancer research.

Our researchers are using novel spatial tools to learn how immune cells affect cancer. “I don’t think we appreciated how much the spatial dynamics of the immune system matter,” says @judithagudo.bsky.social.

Learn more about what researchers are learning from this technology: bit.ly/49uOtSg

Honored to contribute on this piece explaining why cancer comes back (sometimes years later) with leaders in the field!🤩

Why cancer can come back years later — and how to stop it www.nature.com/articles/d41...

Why cancer can come back years later — and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Important to see the acknowledgement of cancer dormancy & that top journals continue to highlight & publish on this topic. This problem is now studied in major Institutions worldwide. Congrats to all who work in this space! It is making & will make a difference! www.nature.com/articles/d41...

Why cancer can come back years later — and how to stop it Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment

go.nature.com/3NgcKDT

Dr. Judith Agudo of Dana-Farber Cancer Institute

In commentary published in Cancer Cell, @danafarber.bsky.social’s @judithagudo.bsky.social contends that integrating cancer cell phenotypic heterogeneity into spatial analyses is essential to reveal the mechanisms that generate TIME diversity and address resistance to immunotherapy. bit.ly/496Mc0Y.

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

So exciting!! Congrats!! I cannot wait to read it🤩.

Congrats! Indeed, so beautiful!

Interferons in health and disease The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Bone appetite: bone-derived factors feed distant immune suppression The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically impair immune function, abrogating immunotherapy response. Bone metastases led to osteopontin (OPN) production, which suppressed immunity in distal lesions. This highlights a novel cross-organ communication hindering antitumor immunity.

Bone appetite: bone-derived factors feed distant immune suppression

Bone appetite: bone-derived factors feed distant immune suppression The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically…

www.sciencedirect.com/science/arti...

Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Congrats!

Congratulations!!!!🎊

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social

PICI Investigator @judithagudo.bsky.social, PhD, was recognized with the 2025 CRI Lloyd J. Old STAR Award, one of immuno-oncology’s highest honors from the Cancer Research Institute (CRI). Congratulations, Dr. Agudo!

www.cancerresearch.org/media-room/2...

Thanks to other support that enabled this recognition @parkerici.bsky.social the NYSCF and the department of defense breast cancer program

CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy - Cancer Research Institute The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs—five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting resea...

Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social

NIH funding to HMS, including for ImmGen, has been terminated. This threatens tools used by 10,000+ immunologists globally. Please email support for ImmGen’s value to you to Immgen(at)gmail.com, your Senator (US), or US Embassy (abroad). Thanks The ImmGen Team #immgen #supportScience #NIHfunding

Thanks @reinacampos.bsky.social for inviting me to @lji.org and UCSD. This has been a super fun visit! it is so amazing and energizing to meet in person!

Thanks a lot for inviting me. I am so honored! And excited🤩

I look forward to hosting @judithagudo.bsky.social at LJI, please join us! snacks and **Free parking**

Thanks a lot!☺️ I hope things are good on your side!