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Josh

@reeding-biochemist

Lover of chemical biology and all things neuropsychology & immunology. Though not my thing, also interested in climate research. Avid swimmer & hiker, occasional cyclist, amateur yogi. πŸ³οΈβ€πŸŒˆβœŠπŸ‰

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13.12.2024
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Latest posts by Josh @reeding-biochemist

It would take a two-word amendment to 42 U.S.C. Β§ 1983 to subject ICE agents and other federal law enforcement officers to the same liability for constitutional violations that local and state officers currently face.

If Congress actually cared about what it's seeing, it could pass that overnight.

12.01.2026 22:56 πŸ‘ 14702 πŸ” 4897 πŸ’¬ 262 πŸ“Œ 258
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"The virus can lead to brain swelling, which can cause lasting damage, including blindness, deafness and intellectual disabilities..."

www.nytimes.com/2025/12/11/w...

14.12.2025 05:14 πŸ‘ 6562 πŸ” 2942 πŸ’¬ 624 πŸ“Œ 283
Sick in a Hospital Town: A Story of American Health Care | Story Trailer
Sick in a Hospital Town: A Story of American Health Care | Story Trailer YouTube video by ProPublica

πŸ“½οΈ WATCH: The most powerful institution in Albany, Georgia, is its hospital: Phoebe Putney Memorial. Yet for decades, the city’s residents have suffered some of the nation’s worst health disparities.

β€œSick in a Hospital Town,” our new 5-part series, drops tomorrow, Dec. 7.

06.12.2025 14:30 πŸ‘ 768 πŸ” 315 πŸ’¬ 19 πŸ“Œ 15
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Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

πŸ”— doi.org/10.1038/s415...

21.05.2025 15:27 πŸ‘ 89 πŸ” 34 πŸ’¬ 8 πŸ“Œ 1

Watch a major campaign being born.

14.04.2025 04:19 πŸ‘ 25759 πŸ” 3004 πŸ’¬ 449 πŸ“Œ 90
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Citrulline regulates macrophage metabolism and inflammation to counter aging in mice Citrulline acts as an endogenous metabolite antagonist to aging and inflammation by regulating mTOR-HIF1Ξ±-glycolysis pathway.

#WeekendRead! #LiveForever! Zhu &co show @ Science Advances that Citrulline decreases with aging & that its long-term administration leads to protective effects by inhibiting mTOR & glycolysis in macrophages, countering inflammaging
www.science.org/doi/10.1126/...

12.04.2025 14:53 πŸ‘ 27 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0

Kinda hard to see a free and fair 2028 election where she doesn’t win by a lot.

12.04.2025 23:04 πŸ‘ 26688 πŸ” 3672 πŸ’¬ 870 πŸ“Œ 150
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Twenty Lessons, read by John Lithgow Key selections from On Tyranny, for viewing and sharing

"On Tyranny" is a #1 NYT bestseller again. I wish the moment were different. But I’m glad the book is useful. And grateful for all the kind words about putting the 20 lessons to work.
snyder.substack.com/p/twenty-les...

12.04.2025 17:33 πŸ‘ 20467 πŸ” 5538 πŸ’¬ 450 πŸ“Œ 278
I hope everyone realizes that scrubbing historical references from web sites is no different than burning books

I hope everyone realizes that scrubbing historical references from web sites is no different than burning books

12.04.2025 12:14 πŸ‘ 46313 πŸ” 11501 πŸ’¬ 671 πŸ“Œ 352
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How to Contact ProPublica or Send a Tip Securely β€” ProPublica Our job is to hold people and institutions accountable. To do that, we need evidence.

Federal workers: We understand you may be taking a risk in contacting us, and we take your confidentiality extremely seriously.

To collect tips, we use encrypted forms and apps, so messages cannot be read by anybody other than you and ProPublica.

➑️ Reach out here: propublica.org/tips

12.04.2025 02:02 πŸ‘ 11994 πŸ” 5811 πŸ’¬ 187 πŸ“Œ 185
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Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics - Nature Biotechnology Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action.

Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action go.nature.com/4a9lMs8
rdcu.be/egMl1

09.04.2025 04:30 πŸ‘ 50 πŸ” 14 πŸ’¬ 1 πŸ“Œ 0

Exciting! Can’t wait to read it @eeschenberg.bsky.social

07.04.2025 17:56 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

You can still register for today's talk in our Lecture Series! Just click on this link to join the talk and discussion at 4pm (CET) on zoom: rotorub.wordpress.com/roto-lecture...
#HPBio #PhilSci #PhilMed

07.04.2025 09:21 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

In years to come, the people who did this will be the ones who will go to jail.

07.04.2025 05:23 πŸ‘ 38459 πŸ” 9296 πŸ’¬ 2271 πŸ“Œ 593
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Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...

06.04.2025 12:41 πŸ‘ 15 πŸ” 5 πŸ’¬ 0 πŸ“Œ 2
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Simulating 500 million years of evolution with a language model More than 3 billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here, we show that language models trained at scale on evolutionary data can genera...

In a new Science study, researchers present ESM3, a protein language model that enables the programmed generation of protein structure and sequence in response to user prompts.

Learn more: scim.ag/40l2z3J

26.02.2025 20:08 πŸ‘ 100 πŸ” 20 πŸ’¬ 0 πŸ“Œ 3
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16.02.2025 14:22 πŸ‘ 33673 πŸ” 8535 πŸ’¬ 251 πŸ“Œ 222
From EARTHSEED: THE BOOKS OF THE LIVING
Choose your leaders with wisdom and forethought.
To be led by a coward is to be controlled
by all that the coward fears.
To be led by a fool is to be led
by the opportunists who control the fool.
To be led by a thief is to offer up your most precious treasures to be stolen.
To be led by a liar is to ask to be told lies.
To be led by a tyrant is to sell yourself and those you love into slavery.

From EARTHSEED: THE BOOKS OF THE LIVING Choose your leaders with wisdom and forethought. To be led by a coward is to be controlled by all that the coward fears. To be led by a fool is to be led by the opportunists who control the fool. To be led by a thief is to offer up your most precious treasures to be stolen. To be led by a liar is to ask to be told lies. To be led by a tyrant is to sell yourself and those you love into slavery.

from β€œParable of the Talents” by Octavia Butler

16.02.2025 14:28 πŸ‘ 18269 πŸ” 6519 πŸ’¬ 367 πŸ“Œ 394
This is figure 2, which shows z-scored voxel-wise PET images of the exceptional resilience mutation carrier and of averaged symptomatic mutation carriers relative to non-carriers.

This is figure 2, which shows z-scored voxel-wise PET images of the exceptional resilience mutation carrier and of averaged symptomatic mutation carriers relative to non-carriers.

A study in Nature Medicine of a rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset. https://go.nature.com/41fiZfS πŸ”’

16.02.2025 17:23 πŸ‘ 27 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1

BREAKING: VIRUS FROM NEVADA DAIRY WORKER WITH BIRD FLU HAS THE SAME GENETIC MUTATION seen in the Nevada cows – a change of PB2 D701N that has previously been assoc with more efficient virus replication in ppl & mammals.

CDC told Fortune that the D1.1 variant in this worker is the same strain of

11.02.2025 00:12 πŸ‘ 12670 πŸ” 4005 πŸ’¬ 459 πŸ“Œ 325
Mike Lee tweets "name a fascist dictator whose agenda entailed limit the size cost and power of government."

Elon quote tweeted it with a laugh emoji and an arrow hitting a bullseye emoji.

Mike Lee tweets "name a fascist dictator whose agenda entailed limit the size cost and power of government." Elon quote tweeted it with a laugh emoji and an arrow hitting a bullseye emoji.

Perhaps if he had not spent so much time playing video games so that he could be the #1 video game player he would know that the answer to this question is "All of them."

05.02.2025 20:55 πŸ‘ 24580 πŸ” 2935 πŸ’¬ 593 πŸ“Œ 131
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Hello #Bluesky! Let's talk diseases, medicine, history, biology, and whatever else is on your mind/bookshelf.

12.11.2024 22:06 πŸ‘ 108 πŸ” 6 πŸ’¬ 12 πŸ“Œ 2
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β€œLike and Subscribe”: A Compendium of Infectious Diseases Audio Podcasts Abstract. In little more than 15 years, the podcast has gone from being virtually unknown to becoming a multibillion-dollar industry. There are an estimate

A peer-reviewed guide to infectious disease podcasts?! And @tpwky.bsky.social made the list?! Yes please!!

academic.oup.com/ofid/article...

27.11.2024 04:47 πŸ‘ 26 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1
This figure shows the potential mechanisms of immune-mediated liver injury from checkpoint inhibitors, showing key steps in monocyte recruitment and activation, CD8+ T cell recruitment and activation, and hepatocyte apoptosis

This figure shows the potential mechanisms of immune-mediated liver injury from checkpoint inhibitors, showing key steps in monocyte recruitment and activation, CD8+ T cell recruitment and activation, and hepatocyte apoptosis

#Immunotherapy has changed the treatment landscape for patients with cancer. This REVIEW explores immune-mediated liver injury from checkpoint inhibitors, from mechanisms to management
www.nature.com/articles/s41...

#Sharedit link: rdcu.be/d5IOa

#Oncsky #Gastrosky #Liversky

09.01.2025 09:20 πŸ‘ 15 πŸ” 4 πŸ’¬ 0 πŸ“Œ 1

Last time I checked, nobody voted for the richest man in the world to run the federal government.

20.12.2024 21:16 πŸ‘ 4554 πŸ” 968 πŸ’¬ 293 πŸ“Œ 64
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Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...

In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬πŸ§ͺ
www.science.org/doi/10.1126/...

20.12.2024 17:14 πŸ‘ 55 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0

People paying attention to the drone stuff, am I missing something or is there no actual evidence of large drones?

20.12.2024 00:59 πŸ‘ 3758 πŸ” 82 πŸ’¬ 326 πŸ“Œ 15
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β€˜Unofficial co-president’: Sen. Warren presses President-elect Trump for answers on Elon Musk’s role Warren is demanding answers from Trump on Musk’s role as a top advisor in his incoming administration, expressing concerns in a letter about the billionaire’s β€œmassive conflicts of interest.”

The American people deserve to know whether an β€œunofficial co-president” is advancing policies that are good for the country or just good for his own bottom line.
www.boston25news.com/news/local/u...

18.12.2024 19:10 πŸ‘ 387 πŸ” 77 πŸ’¬ 20 πŸ“Œ 6
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Molecules of the year 2024 C&EN editors highlight some of our favorite molecules from the past year

α⁠-⁠ʟ⁠-⁠Cyclodextrin has won @cenmag.bsky.social 2024 Molecule of the year! cen.acs.org/synthesis/Mo...

Check out the research paper published in @naturesynthesis.bsky.social earlier this year www.nature.com/articles/s44...
#chemsky

18.12.2024 19:21 πŸ‘ 19 πŸ” 6 πŸ’¬ 0 πŸ“Œ 1