MiCDA-UMISR

“In this randomized clinical trial of a diverse sample of adults with glaucoma and poor self-reported medication adherence at baseline, intervention participants achieved a statistically and clinically significant improvement of 19.7% in medication adherence compared with control participants.”

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Michele Heisler in JAMA Opthamology, “Effect of the Support, Educate, Empower Personalized Glaucoma Coaching Program on Medication Adherence: The SEE Program Randomized Clinical Trial”: myumi.ch/D8jyQ

“Reliable and valid measures of constructs such as Caregiver Strain, Caregiver-Specific Anxiety, and Feeling Trapped can be used by clinicians and care teams to systematically identify caregivers at risk for adverse outcomes, enabling early intervention and targeted support."

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Amanda Leggett in American Journal of Alzheimer’s Disease & Other Dementias, “Validating the Use of TBI-CareQOL Measures in Caregivers of People Living With Dementia”: myumi.ch/61VpJ

“The use of rigorous, shared practices for HCAP adaptation will improve the quality of HCAP data collection, data harmonization, and inferences drawn from cross-national analyses.”

Recommended best practices for construct-centered adaptation of the Harmonized Cognitive Assessment Protocol AbstractObjectives. The Harmonized Cognitive Assessment Protocol (HCAP) neuropsychological assessment approach aims to support the collection of harmonizab

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliates @emilybriceno.bsky.social, Kenneth Langa, and Lindsay Kobayashi in the Journals of Gerontology, "Recommended best practices for construct-centered adaptation of the Harmonized Cognitive Assessment Protocol": myumi.ch/R3j9z

"Earlier menopause was associated with a lower level of cognitive function, and late menopause with faster cognitive decline. Higher education may buffer adverse effects of late menopause."

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Lindsay Kobayashi in Maturitas
Age at natural menopause and cognitive aging in U.S. women: Educational attainment as a modifiable resilience factor
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"The association between arthritis and sleep apnea may be driven by shared inflammatory pathways, especially in the case of rheumatoid arthritis and psoriatic arthritis, which warrant further investigation to understand the potential intricate biological interactions at play..."

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Kelly Marie Bakulski, "Linking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis" myumi.ch/bVMnN

"Factor scores for general cognitive function and domains of memory, language, orientation and executive function were derived from the HCAP neuropsychological test battery (mean of 0 and SD of 1 for each)."

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Lindsay Kobayashi

Do self-reported and objective hearing measures similarly relate to general and domain-specific cognition? Observational cohort study of older adults in England

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"We measured participants' perceived burden in a cohort of older adult research participants enrolled in a longitudinal study of memory and aging at the Michigan Alzheimer's Disease Research Center (MADRC)."

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Kelly Marie Bakulski in Journal of Alzheimer’s Disease

Experiences of participant burden in an Alzheimer's disease research center longitudinal cohort

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"We conducted a pilot trial to assess a patient nudge intervention's implementation feasibility and preliminary effectiveness to prompt deprescribing conversations between PLWD experiencing CNS-active polypharmacy and their primary care clinicians"

New work from MiCDA @umisr.bsky.social WSUPsychology umichmedicine affiliate @dtmaust.bsky.social Amanda Leggett

An Educational Intervention to Promote Central Nervous System-Active Deprescribing in Dementia: A Pilot Study

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"The linkage between inflammation and DNA methylation age acceleration in shaping dementia risk remains understudied. We explored the association of inflammatory cytokines with cognitive impairment.."

New work from MiCDA @umisr.bsky.social @umichsph.bsky.social @um-src.bsky.social affiliates Lindsay Kobayashi Kelly Marie Bakulski Margaret Hicken @erinware.bsky.social

DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment
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"Equipercentile equating enables the derivation of comparable scores, facilitating longitudinal analysis when cognitive test administration procedures change over time. We recommended the use of equated scores for longitudinal analyses using CHARLS cognitive data."

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

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New work from MiCDA @umisr.bsky.social @umichsph.bsky.social affiliate Lindsay Kobayashi in J of Alzheimer's Disease
How to assess cognitive decline when test administration changes across study waves? Harmonizing cognitive scores across waves in the China Health and Retirement Longitudinal Study

"One in three participants in this cohort experienced a negative wealth shock over the 22-year follow-up period (5,184/14,969; 34.6%)."

Memory Trajectories Before and After a Negative Wealth Shock, the United States Health and Retirement Study, 1998-2020 Abstract. The potential for a bidirectional relationship between the experience of a negative wealth shock (a loss of ≥75% in total household wealth over t

New work from MiCDA @umisr.bsky.social @um-src.bsky.social umichmedicine @umichsph.bsky.social affiliates Lindsay Kobayashi Kenneth M. Langa HwaJung Choi

Memory Trajectories Before and After a Negative Wealth Shock, the United States Health and Retirement Study, 1998-2020

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" The gender difference in loneliness underreporting did not meaningfully affect the observed effect modification by gender in our simulations. Our simulation approach may be promising to quantify potential information bias in effect modification analyses."

Could differential underreporting of loneliness between men and women bias the gender-specific association between loneliness duration and rate of memory decline? A probabilistic bias analysis of effect modification

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New work from MiCDA @umisr.bsky.social @umichsph.bsky.social umichmedicine @um-src.bsky.social affiliates Lindsay Kobayashi Kenneth M. Langa in American Journal of Epidemiology

Programs - Michigan Center on the Demography of Aging MiCDA spurs new research on the demography of aging through pilot project and early career development opportunities.

Planning to apply for the MiCDA Research Fellows Program? The deadline is coming up next Monday, March 2nd! For more information on the Research Fellows Program and how to apply, visit micda.isr.umich.edu/programs/.

" Using data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD) and the Health and Retirement Study (HRS), we analyzed 4 biomarkers-the ratio of Amyloid beta 42-40, Glial Fibrillary Acidic Protein...1 -in relation to cognitive outcomes."

New work from MiCDA @umisr.bsky.social umichmedicine @um-src.bsky.social affiliates Kenneth M. Langa Jessica Faul David Weir

Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS)

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"We analyzed a Health and Retirement Study sample, categorizing cognitive status into three levels (normal, cognitive impairment-no dementia, dementia) and using self-reported smoking behaviors. We used multivariable logistic regressions to examine associations and MR to examine potential causality"