Arnau Vich

New Preprint 📢 from our team 🔎 Critical assessment of #intratumor and #low #biomass #microbiome using #longread sequencing

Some studies suggest bacteria 🦠 live inside tumors and influence cancer treatment. But there’s also been a major #debate: in these very​ low-microbe tissue samples, how much 1/

It was a true pleasure to work with you on this, @krukowskihubert.bsky.social ! It’s wonderful to see your hard work recognized. A well-deserved milestone for a fantastic researcher!

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

Engineered probiotic restores GLP-1 signaling to ameliorate fiber-deficiency exacerbated colitis Engineered probiotic delivers bacterial peptide that enhances GLP-1 and restores barrier integrity in diet-modulated colitis.

Highlighting another recent paper from the lab in Science Advances on engineering a gut probiotic to modulate GLP-1 levels and ameliorating colitis. Led by Leonie Brockmann & @carlottaronda.bsky.social . @columbiasysbio.bsky.social @columbiauniversity.bsky.social 🧬🦠💊
www.science.org/doi/full/10....

A bacterial toxin disarms gut defenses against inflammation Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice

New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org

Clarivate Highly Cited Researchers 2025 The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...

Back-to-back recognition! 💪🏼 A huge shoutout to Arnau @arnauvich.bsky.social and Jeroen Raes for once again making @clarivate.com global #HighlyCited2025 list! 🌍✨ @viblifesciences.bsky.social @vibmicrobes.bsky.social clarivate.com/highly-cited...

Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...

Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social

rdcu.be/eMmcT

Another great day at #UEGWeek 2025! 🎉Congratulations to our colleague Jorge Vazquez Castellanos for presenting his exciting work on microbial dysbiosis, inflammation, and the gut–brain axis in IBS at the United European Gastroenterology Week in Berlin🇩🇪 @myueg.bsky.social @vibmicrobes.bsky.social

Huge congratulations to our colleague @arnauvich.bsky.social for presenting his research on FODMAP restriction and gut microbiota in IBS patients at United European Gastroenterology Week 2025 in Berlin🇩🇪👏! #UEGWeek @myueg.bsky.social @vibmicrobes.bsky.social

The most interesting report of the week (IMHO) 🧵

New hope for Alzheimer’s: lithium supplement reverses memory loss in mice Studies in rodents and humans suggest that low levels of the metal contribute to cognitive decline.

www.nature.com/articles/d41...

Alcohol-related liver disease disrupts bile acid synthesis and is associated with compensatory gut microbiota changes Background: Alcohol overuse disrupts liver function and alters microbial gut communities, with alcohol-related liver disease (ALD) accounting for half of all liver-related deaths worldwide. Bile acids...

Super happy to share our latest preprint in #liverdisease & #gut microbiota mechanisms.

www.medrxiv.org/content/10.1...

Global genetic structure of human gut microbiome species is related to geographic location and host health The human gut harbors thousands of microbial species, each exhibiting significant inter-individual genetic variability. Although many studies have ass…

Thrilled to share that our manuscript on strain-level gut microbiome variation across diverse populations and human phenotypes is out today in @cellpress.bsky.social
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
www.sciencedirect.com/science/arti...

🦠🧬🖥️ New Bakta DB v6.0 released!

After a year, it was time for a Bakta database update - and it's a huge one:
- IPS: 330.9M
- PSC: 135.3M
- PSCC: 37M

doi.org/10.5281/zeno...

👇 1/6

A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance Clostridioides difficile, a major cause of antibiotic-associated diarrhea, is suppressed by the gut microbiome, but the precise mechanisms are not ful…

Citation: www.sciencedirect.com/science/arti...

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regulated by nutrient-sensing mechanisms and bacterial viability.

Nature research paper: Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses

https://go.nature.com/3XmyOPD

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

Planning and describing a microbiome data analysis - Nature Microbiology We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.

A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series

Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social

www.nature.com/articles/s41...

Postdoctoral position in bioinformatics of the human gut microbiome - VIB About the Lab Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its clinical applications

We're hiring a postdoc!🚨

Study human-associated microbial communities in health & disease.

🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record

Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social

Commonly used compositional data analysis implementations are not advantageous in microbial differential abundance analyses benchmarked against biological ground truth Previous benchmarking of differential abundance (DA) analysis methods in microbiome studies have employed synthetic data, simulations, and "real data" examples, but to the best of our knowledge, none ...

Excited to share our MicrobiomeBenchmarkData preprint, addressing compositional data analysis for microbiome DA. This Bioconductor package features 3 datasets with biological ground truths. Spoiler: simple methods like LEfSe, Wilcoxon, RNA-seq methods performed well www.biorxiv.org/content/10.1...

Highly Cited Researchers | Clarivate The Highly Cited Researchers 2024 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...

A big congratulations to our incredible team at RaesLab! We’re excited to share that two of our colleagues, Arnau @arnauvich.bsky.social and Jeroen, have been honored on the global #HighlyCited2024 researchers list by @Clarivate🤩🙌🏼 @viblifesciences.bsky.social

clarivate.com/highly-cited...

🙋‍♂️

Although I'm not a big fan of individual recognitions in science- collaboration and teamwork are the real driving forces- I'm honored to be recognised as #HighlyCited2024 by Clarivate. Grateful to all colleagues, mentors and collaborators who made this happen.