Prof Anthony Isles's Avatar

Prof Anthony Isles

@profantisles

#Neuroscience 🧠 | #ImprintedGenes 🧬 | #preclinical models 🐭🧫| MURIDAE lead @mrcmousenetwork.bsky.social | Cardiff University | posting in a personal capacity, mostly about science https://profiles.cardiff.ac.uk/staff/islesar1

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25.09.2023
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Latest posts by Prof Anthony Isles @profantisles

Novelty band names for sale, Β£8 each:
Johnny Crash
Elton Wrong
Poxy Music
The Beagles (ideal for Beatles / Eagles crossover covers band)
Oh! Lemurs
Hairy Styles (band members all need full facial hair)

09.03.2026 14:12 πŸ‘ 19 πŸ” 3 πŸ’¬ 7 πŸ“Œ 0
Preview
Gene regulatory networks: from correlative models to causal explanations Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"

Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?

rdcu.be/e7zx7

09.03.2026 11:30 πŸ‘ 65 πŸ” 26 πŸ’¬ 2 πŸ“Œ 1

Really pleased Glasgow will get to have its day in the sun (Glasgow was set to host the 2020 FENS that was cancelled as a consequence of the COVID19 pandemic)
🧠🏴󠁧󠁒󠁳󠁣󠁴󠁿

09.03.2026 12:21 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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β€œViolet and coltsfoot are among the first Spring flowers. Growing among the roots of the trees are violets and lesser celandine”
Writer: EL Grant Watson
Artist: CF Tunnicliffe

08.03.2026 19:22 πŸ‘ 246 πŸ” 31 πŸ’¬ 1 πŸ“Œ 2
On a breezy day in early spring, the wind tugs at a row of white sheets and bedding on a washing line set in a garden in front of a large white house

On a breezy day in early spring, the wind tugs at a row of white sheets and bedding on a washing line set in a garden in front of a large white house

Breezy Day (1975)
Artist: Gerald Witcomb

05.03.2026 20:11 πŸ‘ 365 πŸ” 42 πŸ’¬ 5 πŸ“Œ 2

We’re excited that the @fens.org Forum 2028 is coming to #Glasgow, with the BNA as host society. We look forward to welcoming neuroscientists from across Europe and beyond to Scotland.

Neuroscience, collaboration, and a Glasgow welcome - and yes, the ceilidh shoes may be required!

06.03.2026 15:50 πŸ‘ 3 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Design of the protein FRET ladder

Design of the protein FRET ladder

Fancy a fresh preprint for Friday? When we were first getting involved with single molecule FRET, there weren't any standard protein molecules that suited our applications to help us develop our pipeline. So we built some! A universal protein ladder for FRET. 🧡 1/

06.03.2026 12:45 πŸ‘ 43 πŸ” 13 πŸ’¬ 1 πŸ“Œ 2

youtu.be/Bnmq4WR83Mw?...

06.03.2026 15:26 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Ian Chapman details end of MRC and BBSRC funding pauses - Research Professional News Calls to restart by May, as new data show lasting real-terms rise in applicant-led funding

UKRI head Ian Chapman details end of MRC and BBSRC funding pauses.

Calls to restart by May, as new data show lasting real-terms rise in applicant-led funding.

www.researchprofessionalnews.com/rr-news-uk-r...

06.03.2026 15:08 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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FENS Forum 2026 | Barcelona, 6-10 July Advancing Neuroscience Together

Who’s going to @FENSorg ?!

I’m really excited to be a Social Media Ambassador for FENS 2026🧠

July 6-10th, Barcelona, Spain πŸ‡ͺπŸ‡Έ

Registration is open until June 2nd!

fensforum.org

#FENS2026 #FENSAmbassador #FENS

06.03.2026 15:13 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Come join us to build great open source tools for neuroscience!

Happy to answer any questions. If ephys and behaviour isn't your thing, we will have some imaging focussed RSE jobs soon!

05.03.2026 15:47 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Two decades of induced pluripotent stem cell research: From discovery to diverse applications Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in repro...

Two decades of iPSCs - a timely overview from Shinya Yamanaka.
www.cell.com/cell-stem-ce...

05.03.2026 16:07 πŸ‘ 7 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
A Glorious March Morning. 10Β°C. Ewes plentiful.

A Glorious March Morning. 10Β°C. Ewes plentiful.

A Glorious March Morning. 10Β°C on the Wolds. Ewes plentiful.

04.03.2026 11:28 πŸ‘ 106 πŸ” 14 πŸ’¬ 1 πŸ“Œ 4

Belfast is a cracking city - looking forward to attending #BNA2027 already!
Get your proposals in and help shape the scientific programme!

02.03.2026 15:30 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
A photo realistic close-up of a mixed selection of biscuits, including chocolate fingers, chocolate digestives, and a lemon puff

A photo realistic close-up of a mixed selection of biscuits, including chocolate fingers, chocolate digestives, and a lemon puff

The mastery of artist Harry Wingfield.
β€˜Biscuits ’
(Yes, it is a painting - from First Picture Book, 1970)

04.03.2026 20:26 πŸ‘ 459 πŸ” 69 πŸ’¬ 11 πŸ“Œ 6

A new video from UKRI on the budget. Kudos to Ian for addressing the community.

More terminology to sit alongside the buckets πŸ’:

Legs 🦡
Jam jars πŸ«™

And a reprise of "applicant led"

I am more confused and I still have questions🧡

youtu.be/osnqHbOywVY

03.03.2026 18:42 πŸ‘ 8 πŸ” 5 πŸ’¬ 1 πŸ“Œ 2
The moon going from full moon to a red moon and starting to go back to a normal full moon, then my camera battery door fell off.

The moon going from full moon to a red moon and starting to go back to a normal full moon, then my camera battery door fell off.

Here's my first edit on the March 3rd Lunar Eclipse. 15 moon shots, 1 foreground. Taken over a 3 hourish period.

04.03.2026 04:22 πŸ‘ 8798 πŸ” 1863 πŸ’¬ 143 πŸ“Œ 71
Preview
How Imprinted Genes Shape Nurturing Behaviours and Neural Circuits Abstract. Genomic imprinting is an epigenetic phenomenon that, in animals, is found only in placental mammals and, to a lesser extent, marsupials. Broadly, differential epigenetic marking of the genom...

New review article from my lab!
🧬🧠🐭

karger.com/bbe/article/...

02.03.2026 13:42 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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"We called London a war zone and moved to Dubai by mistake"

03.03.2026 08:16 πŸ‘ 6604 πŸ” 1564 πŸ’¬ 91 πŸ“Œ 45

I have just sent the following email to my Labour MP, Jeff Smith. Text is in Alt - feel free to use/adapt it. But whatever the case, write to your MP!

03.03.2026 12:34 πŸ‘ 27 πŸ” 18 πŸ’¬ 2 πŸ“Œ 1
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β€œIn the first week of March the wind blows hard, swaying the reeds and bushes and bending the big trees beyond the lake to its cold breath.”

The first page of β€˜What to Look for in Spring”
Artist: CF Tunnicliffe
Writer: EL Grant Watson

01.03.2026 19:59 πŸ‘ 315 πŸ” 56 πŸ’¬ 1 πŸ“Œ 2
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This week is National #CareersWeek

Why not take a look at some of these inspiring resources I’ve collated to weave careers into STEM teaching and learning (link in comments, or follow link to blog in bio)πŸ‘‡

#ScienceIsEverywhere #BeCurious #DrJoScience #STEMCareers

03.03.2026 07:11 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Belfast is a cracking city - looking forward to attending #BNA2027 already!
Get your proposals in and help shape the scientific programme!

02.03.2026 15:30 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Could you help shape the next generation of neuroscientists? 🌟

The BNA Scholars Programme is seeking mentors to support early-career researchers from underrepresented backgrounds.

Learn more & apply:
www.bna.org.uk/policy-advoc...

#Neuroscience #Mentorship #DiversityInScience

27.02.2026 17:02 πŸ‘ 2 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
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New preprint from the lab on synapse development in the nascent neocortical hierarchy!

Using mice that label MAGUK proteins developed by Seth Grant we find key differences in the laminar maturation of association and sensory motor cortices, including delayed, cortex-wide maturation of L1 synapses.

18.02.2026 10:33 πŸ‘ 24 πŸ” 12 πŸ’¬ 1 πŸ“Œ 0
Preview
How Imprinted Genes Shape Nurturing Behaviours and Neural Circuits Abstract. Genomic imprinting is an epigenetic phenomenon that, in animals, is found only in placental mammals and, to a lesser extent, marsupials. Broadly, differential epigenetic marking of the genom...

New review article from my lab!
🧬🧠🐭

karger.com/bbe/article/...

02.03.2026 13:42 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Happy Casimir Pulaski Day, ya filthy animals.

youtu.be/TfEkDqP34xo?...

02.03.2026 11:52 πŸ‘ 37 πŸ” 9 πŸ’¬ 1 πŸ“Œ 0
A bleak, stark oil painting in shades of brown and cream of waterlogged fields under a flat white sky dotted with bare elm trees

A bleak, stark oil painting in shades of brown and cream of waterlogged fields under a flat white sky dotted with bare elm trees

Other work of the Ladybird artists.
β€˜February Fill Dyke’
Artist: Rowland Hilder

28.02.2026 19:26 πŸ‘ 398 πŸ” 51 πŸ’¬ 10 πŸ“Œ 2
March Morning Skies. 12Β°C with a Southerly breeze. Plum blossom in the hedges.

March Morning Skies. 12Β°C with a Southerly breeze. Plum blossom in the hedges.

March Morning Skies. 12Β°C and a Southerly breeze. Plum blossom in the hedges

01.03.2026 14:17 πŸ‘ 123 πŸ” 19 πŸ’¬ 2 πŸ“Œ 4
Bright and breezy illustration of three daffodils painted on a simple, grey background

Bright and breezy illustration of three daffodils painted on a simple, grey background

St David's Day
Dydd GΕ΅yl Dewi

Artist: H Woolley (1954)

01.03.2026 09:00 πŸ‘ 427 πŸ” 89 πŸ’¬ 1 πŸ“Œ 5