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Elliott Lab

@elliottlab

At the Department of Biochemistry, University of Oxford, UK. Structural biology. Ubiquitination pathways. elliottlab.web.ox.ac.uk

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Posts 07.12.2025
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Latest posts by Elliott Lab @elliottlab

An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...

RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP

21.02.2026 23:31 👍 75 🔁 33 💬 1 📌 4
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🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it?

Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear.

Our new paper in Cell Death & Differentiation uncovers one. 🧵👇
nature.com/articles/s41...

16.02.2026 12:00 👍 33 🔁 14 💬 2 📌 1
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Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026

10.01.2026 00:47 👍 34 🔁 21 💬 1 📌 3

We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social

06.01.2026 20:54 👍 29 🔁 14 💬 0 📌 0

We have an opening for a research support officer. Come and join us! Please share.

22.12.2025 12:09 👍 17 🔁 22 💬 0 📌 0
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SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.

08.12.2025 13:16 👍 24 🔁 18 💬 0 📌 1
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SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

11.12.2025 06:09 👍 133 🔁 65 💬 10 📌 6
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UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

09.12.2025 13:21 👍 37 🔁 15 💬 4 📌 2