@drlipid
Longtime Lipid/Lipoprotein Educator with an extensive resume including Associate Editor of Journal of Clinical Lipidology. Practiced in NJ for 37 years. Has done 4000 lectures in all 50 states & authored many publications. Has two major awards from NLA
Statins enter every cell in the body including the brain as they can pass thru the BBB. Statin's CV benefit comes from reducing apoB, by inhibiting HEPATIC cholesterol synthesis which in turn upregulates LDL receptor & the liver, has far more LDLRs than other peripheral tissues.
Nice to join several top neurologists on this paper. A Preventive Neurology Perspective on Promoting Brain Health and Preventing Cardiovascular Disease. Clin Geriatr Med 2026 doi.org/10.1016/j.cg... @nationallipid.bsky.social @aspcardio.bsky.social @eassociety.bsky.social
There are 2 forms of cholesterol - An alcohol ending in -OL (the active "free" form) & an ester ending in -YL (the storage/transportation form). The esterifying enzymes attach an acYL group (fatty acid) to free cholesterol are ACAT 1 & 2 in specific cells & LCAT (alpha and beta) within lipoproteins
CIMT can be even more important than CAC as vascular pathology appears before calcification. A significant proportion of low-risk individuals may have undetected plaque, justifying reconsideration of early screening strategies. Open access at pubmed.ncbi.nlm.nih.gov/41449009/
More Basics: Apart from biochemistry there is Clinical Chemistry and the cellular machinery that control everything. @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social
This is a 9-minute podcast in the famed Lipid Curious series by Visha Priya Pulipati that sort of positions who I am and how I got there. I stumbled into and tried to master the importance of lipids before most clinicians. Enjoy. www.buzzsprout.com/2508586
More of my teaching slides to help all better understand lipid and lipoprotein complexities. Wish you could view the animated versions. Note: lab lipoprotein cholesterol assays measure both free and esterified cholesterol. See if you can figure out why one of obicetrapib's trials was called TULIP.
New AHA pediatric hypertriglyceridemia guideline - www.ahajournals.org/doi/10.1161/ATV.0000000000000195 @nationallipid.bsky.social @aspcardio.bsky.social
Part of the HDL story not usually taught: After receiving TG from apoB particles via CETP, HDLs undergo lipolysis via the actions of hepatic & endothelial lipase. Ultimately the products of lipolysis are very small HDLs & apoA-I which are handled by the Megalin/Cubam complex in the renal tubules
CETP inhibition: A Potential Pathway for Targeting Cholesterol Dysregulation in AD. Open access at www.sciencedirect.com/science/article/pii/S266666772600036X?via%3Dihub @nationallipid.bsky.social @familyheartfdn.bsky.social @aspcardio.bsky.social @menopausesociety.bsky.social
These HDL slides illustrate some of the many complex pathways used by HDL's as it contributes to cholesterol homeostasis. Of course, the HDL-C metric tells you nothing about whether these pathways are occurring or not. If you are using any ratio that includes HDL-C, please cease immediately.
To help all better understand lipoprotein concentrations. Moles are a way of counting #s & 1 mole is the # of particles or 10 to the 23rd power & a nanomole is a billionth of a mole or 10 to the 9th power. HDLs BY FAR are the most numerous particles in plasma & VLDLs & IDLs are by far the fewest.
Here is where we are with PCSK9 inhibitors: 3 on the market, another (new class of drugs) just approved and coming in the near future an oral one. @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social
Some PCSK9 inhibitor news and we have a new class of medication - The Cibeps. @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social
Menopause Hormone Therapy May Boost GLP-1 Drug Benefits - www.medpagetoday.com/endocrinology/menopause/119594 @nationallipid.bsky.social @aspcardio.bsky.social @menopausesociety.bsky.social
Demand your labs to start using this NIH developed extremely accurate LDL-C calculation (Modified Sampson) even when TG are high. Stop ordering direct LDL-C. LabCorp. is now using this equation. myadlm.org/cln/articles/2026/januaryfebruary/update-to-equation-for-estimating-ldl-c-proposed
Here is another of my graphics: this time on atherogenesis. The sine qua non means there cannot be atherosclerosis unless there are cholesterol molecules in the arterial wall. Over a long time, they are delivered by apoB-containing vehicles called lipoproteins, the vast majority of which are LDLs.
Here is a learning experience on a crucial topic to put at the top of your list. I so enjoyed listening to two of my favorite colleagues discussing the brain during the menopause transition. @_CynthiaThurlow and Dr Kellyann Niotis www.cynthiathurlow.com/podcast/epis...
Had 2 hours with Dr Frederick Feit on SiriusXM radio this morning. I spun a lot of lipids/lipoproteins & took several calls. If you are a subscriber to that channel, the chat is archived there for relistening. www.siriusxm.com/player/episode-audio/entity/98cd4f0e-aad6-e0ae-566c-77c64cd526c7
Tomorrow from 6-8 AM, on @SIRIUSXM I will be a guest of famed cardiologist Dr Frederick Feit on Doctors Radio channel. I am the official historian and "Honorary Battalion Chief at the 211-year old Paterson NJ Fire Department. See www.patersonfirehistory.com/pfh-contribu...
Set your alarm clocks - I will be interviewed by renowned cardiologist Dr Frederick Feit on SiriusXM Doctor's Radio (Channel 110) live between 6:00 and 8:00 AM EST next Wednesday, January 21 (repeated periodically). Discussing what else - lipids, Menopausal Health & answering caller's questions.
Happy New Year to Lipidaholics - First lesson of 2026 providing some basics on Low Density Lipoproteins (LDLs): (1) Structure (2) Properties (3) Particle & cholesterol metrics (4) Changing apoB mass metrics (mg/dL) to particle numbers (nmol/L). @nationallipid.bsky.social @aspcardio.bsky.social
I am happy to be included on this excellent 2025 Wrap Up with various podcast clips by some key experts
@theproof discussing ASCVD, Lipids, Lipid targets, Lp(a), Hypertension, Keto trial, Nutrients, Cancer and much more. youtu.be/GMB9zFdaiaA?... @nationallipid.bsky.social @aspcardio.bsky.social
For Lipidologists and lipid interested folks: More on Lysine binding domains on apo(a) component of Lp(a) and the assay measuring oxPL-apoB (oxidized phospholipids on apoB) @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social
More on my LDL discussion series: Enjoy my graphics as they speak for themselves @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social
Among 450,177 individuals with fibroids and 2,250,885 controls (mean age: 41 years, SD 6.3), uterine fibroids were associated with sustained increased ASCVD risks up to 10 years postdiagnosis, supporting targeted ASCVD prevention: OPEN ACCESS www.ahajournals.org/doi/10.1161/JAHA.125.044014
Part 2 of the AMA I did with @_CynthiaThurlow www.cynthiathurlow.com/post/ep-527-...
For those interested in quickly increasing their understanding of lipids and lipoproteins take a peak at this site called Lipid Curious" by endocrinologist/Lipidologist Vishnu Priya Pulpati that offers 10 concise podcasts www.buzzsprout.com/2508586/epis... or podcastindex.org/podcast/7364...
New Book with a very appropriate title (Graphic 1). The dilemma of science today are the Internet Charlatans - They have now also left social media and invaded the FDA and HHS hachettebookgroup.com/titles/moise...
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