Stavroula Boukoura (Stavi)

New paper alert 🥳Excited to share our new paper in NAR Cancer showing that ribosome biogenesis is significantly upregulated in hepatocellular carcinoma and highlighting the nucleolus as a promising therapeutic vulnerability. Check it out here: academic.oup.com/narcancer/ar...

Finally out! We introduce NoLMseq, a #nucleolus laser microdissection method to capture single-cell genome-nucleolus interactions in normal and stressed nucleoli, revealing novel insights into genome organization & function. www.nature.com/articles/s41...

Our Spatial Genome Organisation 2025 attendees! Fantastic presentations, discussions & collaborations have taken place over the past 2 days, with plenty more to come. Its been a pleasure working with Karim, Irene & Matthias, looking forward to what the future holds for this brilliant series. #SGO25

Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 Merigliano et al. identified a non-canonical, “off-pore” role for nucleoporins in genome stability and in the spatial regulation of homologous recombination in multicellular eukaryotes. Nup98 condensates form at DNA breaks within pericentromeric heterochromatin to prevent aberrant recombination by excluding Rad51, while promoting the mobilization of repair sites through immiscibility with heterochromatin protein 1 (HP1) condensates.

Online Now: Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51 Online now:

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC) The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

📅 Our next Chromosome Biology Club is next week!

Join us on March 25th at the Biocenter for exciting talks from:
◉ Johanna Kliche (Nilsson group, @nilssonlab.bsky.social)
◉ Oline Pade Jensen (Lisby group)
◉ Luke Greenhough (Steve West group, @xrnchew.bsky.social)

Mark your calendars! #CBC

Nuclear and genome dynamics underlying DNA double-strand break repair Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...

🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬

📖 Free access: rdcu.be/edViW

Please 🔄 ❤️

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives.

An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
 
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...