Synlett Journal

Fighting multidrug-resistant cancer🧬 Rohit Bhatia @rohitbhatia10.bsky.social & co-workers review five-membered heterocyclic hybrids as versatile anticancer scaffolds with strong efficacy and lower toxicity💊
#anticancer

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From lab to pilot scale🔬➡️🏭 Yadong Wu & co-workers develop a practical, four-step route to lurasidone hydrochloride with purifiable intermediates and 42% yield, ideal for industrial production 💊

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Tricking bacteria to stop #biofilms 🦠 Chutima Jiarpinitnun & co-workers design squaramide AHL mimics that interfere with P. aeruginosa quorum sensing, blocking biofilm formation without killing cells⚡
#squaramide

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Metal-free asymmetric synthesis🌱Chandrakumar Appayee & co-workers showcase how chiral secondary #amines, especially proline-derived, drive enamine & iminium #catalysis for diverse C–C and C–heteroatom bond formations under eco-friendly conditions✨

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Accessing chiral 1,2-amino alcohols✨Gong  & co-workers developed a diastereoselective addition of Grignard & MeLi reagents to a pyrrolo-oxazolone scaffold, giving diverse CAUAs with terminal esters.
#Diastereoselectivity

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C2-selective Pd-catalyzed C–S #coupling! Jackson & Neufeldt report new conditions enabling rare C2 #functionalization of 2,4-dichloropyrimidines, complementing traditional C4-selective methods and raising intriguing mechanistic questions about oxidative addition ✨
#catalysis

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Cracking a century-old puzzle🔍 Andrew Smith & co-workers explore [1,2]-rearrangements of #ammonium ylides—tackling selectivity, probing radical pathways, and redefining how these elusive allylic shifts may occur✨
#organocatalysis #radicals

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Asymmetric Ni #catalysis at work🧪 Takuya Kurahashi & co-workers introduce a tyrosine-derived FOXAP ligand enabling aziridine–imine cycloadditions—building #imidazolidines with up to 97% ee via enantioconvergent design🔬
#nickel

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Join Thieme #Cheminar “Strain-Release Chemistry”🔬 with our speakers Dr. Durga Prasad Hari (🇮🇳), Prof. Jérôme Waser (🇨🇭) @lcsolab.bsky.social & Prof. Peter Wipf (🇺🇸), hosted by our assoc. editor Prof. Akkattu T. Biju

📅February 24, 2026
⏰11 AM (GMT+1)

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Chalcones vs Alzheimer’s🧠 Prabha & Rajput review how #chalcone hybrids target AChE, BChE & MAOs—revealing SAR insights and multitarget potential for next-gen anti-AD therapeutics🔬

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Xie, Lai & co-workers report a NHC-catalyzed #acylalkylation of #indoles for the construction of multisubstituted benzopyrrolizidinones. Broad scope, excellent diastereoselectivity, and late-stage functionalization of pharmaceutical skeletons🔬
#dearomatization #NHC

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✨Celebrating 25 years of #NHC innovation! The Nolan group has transformed N-heterocyclic carbene chemistry, from versatile organometallic ligands to anticancer NHC–metal complexes and visible-light #gold photocatalysts. A true impact on #catalysis & #GreenChemistry 🌱

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Congratulations to Kevin, Andy and Will on their @synlettjournal.bsky.social paper! www.thieme-connect.com/products/ejo...

Light-driven radical chemistry in action✨ A systematic study by Samuel Oger & Gwilherm Evano shows that sulfonamides undergo exclusive exo-dig cyclization under Cu- #photoredox conditions, giving access to azetidines, pyrrolidines, piperidines & azepanes 🔬
#copper

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Eight years of light-driven #nickel catalysis💡Bartholomäus Pieber traces the journey from reusable carbon nitride photocatalysts to dye-sensitized metallaphotocatalysts, COFs, and tailored conjugated polymers⚗️
#photocatalysis

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Building quaternary carbons with #nickel 🔬 Wang & Shi report a Ni-catalyzed, Markovnikov-selective addition of #organoborons to simple alkenes using a diimine ligand, enabling high-yield access to all-carbon quaternary centers. Bulky chiral ligands also allow stereocontrol⚗️

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Green synthesis of #atropisomers 🌿Christian Wolf & co-workers report a base-promoted Csp²–Csp³ bond formation between #fluorooxindoles and 4-chloro-3-nitrocoumarins, yielding atropisomeric structures with high diastereoselectivity in just 1 h at rt💡
#coumarins

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#Ruthenium to the rescue🧬Bhatia @rohitbhatia10.bsky.social Singh & co-workers highlight Ru-based anticancer agents as promising alternatives to traditional platinum drugs💊, offering lower toxicity, potent anticancer/anti-metastatic activity, and precise control⚡

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✨Cluster: 'Small Molecules in Medicinal Chemistry'✨

Advancing NSCLC therapy💊Udit Chaube reviews mTOR #inhibitors like RM-018 & RMC-4998 targeting KRASG12C mutations, along with plant-derived compounds showing potent antitumor activity 🧬
#cancer

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Turning alkenes into chiral building blocks✨Wanderley & Crisenza showcase how #electrosynthesis is revolutionizing asymmetric 1,2-difunctionalization. Their “Sew & Cut” strategy merges pericyclic 1,3-dipolar cycloadditions with radical reactivity for complexity generation🧪

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✨Cluster 'Small Molecules in Medicinal Chemistry'✨

Unnatural amino acids are privileged scaffolds in drug discovery. Keisuke Tomohara & co-workers present a new Account detailing efficient synthetic routes using readily accessible building blocks🧪

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✨Cluster 'Small Molecules in Medicinal Chemistry'✨

Dobrydnev & team have developed a simple, scalable way to synthesize unknown heterocyclic systems🧪By using intramolecular cyclization, they’ve unlocked effortless access to complex keto sulfoximines

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✨Cluster 'Small Molecules in Medicinal Chemistry'✨

How have small-molecule drugs evolved over the last decade?🧪 Singh, Mahindroo & team examine how pharmacophore-based design is transforming treatment for rare diseases and neurological conditions🧬

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Harnessing #electrocatalysis for greener chemistry🌱Dapkekar & Satyanarayana showcase their lab’s advances in electro-organic synthesis, from 3° alcohols to spiro-cyclohexadienone indenes, β-hydroxy-selenides & more, all without hazardous oxidants/reductants⚗️

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✨Cluster 'Small Molecules in Medicinal Chemistry'✨

Unlock the #proteome with succinimide-containing probes🧪 Developed by William Parsons & co-workers, these new reactive groups are expanding how we study #enzyme activity

#OpenAccess 👉 www.thieme-connect.com/products/ejo...

✨Cluster 'Small Molecules in Medicinal Chemistry'✨

New insights from MacQueen & Billingsley on #indolactam alkaloids🧬 Discover how these potent activators are being optimized for #tumor suppression💊

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Introducing Therapeutics NOW – Thieme’s new Gold Open Access journal driving breakthroughs in translational therapeutic research.
✅ Interdisciplinary by design
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✅ Ultra-fast peer review via Select Crowd Review
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✨Cluster 'Small Molecules in Medicinal Chemistry'✨

Dive into the future of #cancer therapy with the discovery of a novel TRK-selective inhibitor🧬 This next-gen candidate by Ito & co-workers offers high selectivity and reduced drug interaction risks💊

#OpenAccess for a limited time 👉 buff.ly/IVHXIb3

Green chemistry meets bioactive scaffolds🌱 S. Chaudhuri & co-workers use CBr₄ as a metal-free catalyst for regioselective synthesis of #dihydrochromenoindole fused heterocycles. Scalable, reproducible & bioactive, streamlined synthesis with minimal side reactions🔬

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